東京大学 · 医学
Taku Saito教授の研究室は、変形性関節症の発症メカニズムと再生医療の両面から、関節軟骨のホメオスタシスと疾患発症の分子ネットワークを解明することを目的としています。特に、NotchおよびNF-κBといったシグナル経路の役割を解明し、ヒト induced pluripotent stem cells（iPSC）を用いた軟骨再生医療の実現に向けた技術開発も進めています。移植後のiPSC由来軟骨の成熟と安全性の評価も重要な研究テーマです。
Figures are computed from collected data and may differ slightly.
Osteoarthritis (OA) is a multi-factorial and highly prevalent joint disorder worldwide. Since the establishment of murine surgical knee OA models in 2005, many of the key molecules and signalling pathways responsible for OA development have been identified. Here we review the roles of two multi-functional signalling pathways in OA development: Notch and nuclear factor kappa-light-chain-enhancer of activated B cells. Previous studies have identified various aspects of articular chondrocyte regula
Induced pluripotent stem cells (iPSCs) are a promising cell source for cartilage regenerative medicine. Meanwhile, the risk of tumorigenesis should be considered in the clinical application of human iPSCs (hiPSCs). Here, we report in vitro chondrogenic differentiation of hiPSCs and maturation of the differentiated hiPSCs through transplantation into mouse knee joints. Three hiPSC clones showed efficient chondrogenic differentiation using an established protocol for human embryonic stem cells. Th
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