京都大学 · 化学
Takuya Kubo教授の研究室は、磁性ナノ粒子や分子認識ポリマーを応用したスマートな薬物送達システムの開発を柱としています。特に、Fe₃O₄ナノ粒子を基盤にした磁熱反応性デリバリー系や、タンパク質の特異的捕捉を可能にする分子イムプリンティング技術の開発が進んでいます。また、光反応性カップリング剤やフラーレン修飾シリカモノリスを用いた高効率なナノ材料固定技術や、π-π相互作用を活用した分離材料の開発も展開しています。
Figures are computed from collected data and may differ slightly.
A new stimulus-responsive drug delivery system using Fe<sub>3</sub>O<sub>4</sub> nanoparticles coated with molecularly imprinted polymer (MIP) is reported. Magnetic thermal seeds (MTS) with their size controlled between 10 and 20 nm that could generate heat under an alternate current (AC) magnetic field were modified with a thermal-responsive MIP by grafting polymerization for effective release of an anticancer drug, methotrexate (MTX). The MIP-coated MTS showed the superparamagnetic property as
We report molecularly imprinted polymers (MIPs) for selective adsorption of proteins using a poly(ethylene glycol) (PEG)-based cross-linker with ionic monomers. To clarify the utility of the concept for preparation of the imprinted polymers using a PEG-based cross-linker, we employed lysozyme or cytochrome c as a template molecule. A few sulfonic functional monomers including sodium allylsulfonate, 2-acrylamido-2-methylpropanesulfonic acid, and sodium p-styrenesulfonate were utilized. After opti
A highly efficient photocoupling agent, based on perfluorophenylazide (PFPA)-conjugated polyallylamine (PAAm), was developed for the efficient immobilization of polymers, nanoparticles, graphene, and small molecules. The conjugate, PAAm-PFPA, was synthesized, and the percentage of the photoactive moiety, PFPA, can be controlled by the ratio of the two components in the synthesis. By treating epoxy-functionalized wafers with PAAm-PFPA, photoactive surfaces were generated. Compared with the PFPA s
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