東京大学 · 医学
Tetsuo Sasano教授の研究室では、心房細動（AF）の病態メカニズム、特に炎症が関与する心房再-entry基盤の形成に注目し、治療に応用可能な新規戦略の開発をめざしています。また、特発性心室制動の原因となるIRX3遺伝子変異とヒス-プルキンジ系における機能障害の解明を通じて、健康な心臓における突然死の予防に貢献する遺伝的リスク評価の高度化を推進しています。
Figures are computed from collected data and may differ slightly.
Atrial fibrillation (AF) is one of the most common arrhythmias encountered in clinical practice. AF is a major risk factor for stroke, which is associated with high mortality and great disability and causes a significant burden on society. With the development of catheter ablation, AF has become a treatable disease, but its therapeutic outcome has been limited so far. In persistent and long-standing AF, the expanded AF substrate is difficult to treat only by ablation, and a better understanding
IRX3 genetic defects and resultant functional perturbation in the His-Purkinje system are novel genetic risk factors of idiopathic VF, and would improve risk stratification and preventive therapy for SCD in otherwise healthy hearts.
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