京都大学 · 医学
岡田知久志教授の研究室では、脳神経疾患や循環器系疾患の神経画像診断・病態解明を目的とした画像診断学的・実験的アプローチを展開しています。特に慢性疲劳症候群の脳内代謝異常や脳動静脈奇形(AVM)が神経径路に与える影響を、拡散テンソル画像法を用いて評価しています。また、動脈痙攣の動物モデルを構築し、血液成分が血管壁に及ぼす影響を細胞病理学的に解明する研究も進めています。
Figures are computed from collected data and may differ slightly.
These results are consistent with previous reports of an abnormal distribution of acetyl-L-carnitine uptake, which is one of the biochemical markers of chronic fatigue syndrome, in the prefrontal cortex. Thus, the prefrontal cortex might be an important element of the neural system that regulates sensations of fatigue.
A new animal model for vasospasm using rat femoral artery has been developed. Whole blood, washed erythrocytes, or leukocytes in platelet-rich plasma were selectively applied to the adventitial surface of the femoral artery for 7 days in 15 rats, after which the vessels were perfusion-fixed and examined by light and transmission electron microscopy and immunohistochemistry. As compared with matched control arteries, there was a prominent reduction in luminal cross-sectional area after 7 days in
<b>BACKGROUND AND PURPOSE:</b> We hypothesized that diffusion tensor fiber tractography would be affected by intracranial arteriovenous malformation (AVM). The purpose of the present study was to evaluate the influence of intracranial AVM on corticospinal tract and optic radiation tractography. <b>MATERIALS AND METHODS:</b> The subject group comprised 34 patients with untreated intracranial AVM. Hemorrhage was present in 13 patients and absent in 21 patients. Perinidal fractional anisotropy (FA)
A new animal model for vasospasm using rat femoral artery has been developed. Whole blood, washed erythrocytes, or leukocytes in platelet-rich plasma were selectively applied to the adventitial surface of the femoral artery for 7 days in 15 rats, after which the vessels were perfusion-fixed and examined by light and transmission electron microscopy and immunohistochemistry. As compared with matched control arteries, there was a prominent reduction in luminal cross-sectional area after 7 days in
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