名古屋大学 · 医学
Tomomi Kotani教授の研究室では、妊娠における胎盤形成とその障害、特に子癇前症の発症メカニズムに注目し、特に拡散型胎児性栄養細胞（EVT）の移動・浸潤機能の制御に関与する転写因子AP-2αおよびAP-2γの役割を分子レベルで解明しています。特に、AP-2の発現亢進がEVT機能の抑制に寄与し、子癇前症の発症に結びつく可能性を示唆しています。また、精神的健康状態が妊娠に与える影響についても、日本女性を対象とした疫学的アプローチを通じて、周産期アウトcomesへの影響を検討しています。
Figures are computed from collected data and may differ slightly.
The reduced migration/invasion of extravillous trophoblasts (EVTs) is a key feature of the genesis of preeclampsia. We and others previously reported that transcriptional factors activator protein-2 (AP-2) alpha and AP-2gamma act as suppressors of tumor invasion. The present study examined the expressions of AP-2alpha and AP-2gamma in preeclamptic placenta vs. control placenta and investigated their effect on the function of EVTs. The expressions of AP-2alpha and AP-2gamma were elevated in the p
A trend towards a lower birth weight and shorter gestational age was observed in Japanese women with well-controlled mental disorders, but the effect of well-controlled mental disorders on the perinatal outcome was minimal.
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