東京大学 · 医学
Hamada教授の研究室は、がんの発症と進行に影響を及ぼす腸内細菌や慢性炎症、遺伝的素因といった環境・生物学的要因とがんの分子病理学的特徴を統合的に解明する「分子病理疫学（MPE）」を核とした研究を推進しています。特に、大腸がんにおける*Fusobacterium nucleatum*の役割や、アスピリンの免疫応答への影響、MSI状態に応じた腫瘍免疫微小環境の差異を解明しています。臨床的応用を視野に入れ、個別化医療に資するバイオマーカーの同定や、治療戦略の最適化をめざした疫学的・分子的アプローチを展開しています。
Figures are computed from collected data and may differ slightly.
The presence of <i>Fusobacterium nucleatum</i> (<i>F. nucleatum</i>) in colorectal carcinoma tissue has been associated with microsatellite instability (MSI), lower-level T-cell infiltrates, and poor clinical outcomes. Considering differences in the tumor-immune microenvironment between MSI-high and non-MSI-high carcinomas, we hypothesized that the association of <i>F. nucleatum</i> with immune response might differ by tumor MSI status. Using samples from 1,041 rectal and colon cancer patients w
Purpose Blockade of the programmed cell death 1 (PDCD1, PD-1) immune checkpoint pathway can improve clinical outcomes in various malignancies. Evidence suggests that aspirin (a widely used nonsteroidal anti-inflammatory drug) not only prolongs colorectal cancer survival, but can also activate T cell-mediated antitumor immunity and synergize with immunotherapy through inhibition of prostaglandin E2 production. We hypothesized that the survival benefit associated with aspirin might be stronger in
Molecular pathological epidemiology (MPE) is an integrative transdisciplinary field that addresses heterogeneous effects of exogenous and endogenous factors (collectively termed 'exposures'), including microorganisms, on disease occurrence and consequences, utilising molecular pathological signatures of the disease. In parallel with the paradigm of precision medicine, findings from MPE research can provide aetiological insights into tailored strategies of disease prevention and treatment. Due to
The present nomogram can provide valuable information for tailored decision-making early after the diagnosis of nonresectable pancreatic cancer.
Outcomes of covered and uncovered gastroduodenal SEMS were comparable, although the lower dysfunction rate of covered SEMS observed in the analysis of randomized trials needs further investigation. Antimigration mechanisms for covered SEMS and identification of patients who can achieve longer patency from uncovered SEMS would help improve the outcomes of gastroduodenal SEMS.
Family history of pancreatic cancer was associated with increased risk of this malignancy. Family history of breast or colorectal cancer was associated with the increased risk among AJ men.
EST and EPBD can be safely performed in patients receiving antiplatelet agents. Users of anticoagulants are at high risk of bleeding, and the periprocedural management of these should be further investigated.
Inhibitors targeting the <i>PDCD1</i> (programmed cell death 1, PD-1) immune checkpoint pathway have revolutionized cancer treatment strategies. The TIME (Tumor Immunity in the MicroEnvironment) classification based on tumor <i>CD274</i> (<i>PDCD1</i> ligand 1, PD-L1) expression and tumor-infiltrating lymphocytes (TIL) has been proposed to predict response to immunotherapy. It remains to be determined clinical, pathological, and molecular features of TIME subtypes of colorectal cancer. Using 812
Severe bleeding and perforation following EUS-FNA for pancreatic masses are rare, and the procedure is safe.
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