大阪大学 · 医学
Takahashi教授の研究室は、免疫細粒球（NKT細胞）の発生・機能およびT細胞のサブセットにおける受容体の機能を解明する分野で、特にヒトに特有のCD8陽性NKT細胞の存在や、CD161発現T細胞の多様な免疫応答機能を解明しています。また、神経発生の制御機構として、マウス脳の新皮質神経形成における細胞周期のダイナミクスを解析し、神経産生のスケジューリングメカニズムを明らかにしています。これらの研究は、自己免疫疾患や神経発達障害の理解に貢献する基盤を提供しています。
Figures are computed from collected data and may differ slightly.
Human Valpha24(+) NKT cells constitute a counterpart of mouse Valpha14(+) NKT cells, both of which use an invariant TCR-alpha chain. The human Valpha24(+) NKT cells as well as mouse Valpha14(+) NKT cells are activated by glycolipids in a CD1d-restricted manner and produce many immunomodulatory cytokines, possibly affecting the immune balance. In mice, it has been considered from extensive investigations that Valpha14(+)CD8(+) NKT cells that express invariant TCR do not exist. Here we introduce h
A subset of T cells in human peripheral blood expresses CD161 (NKR-P1A) receptors that are primarily associated with NK cells. In the current study we isolated blood T cell subsets according to the expression of CD161 and examined their contents of naive, central memory, and effector memory cells and their capacities for proliferation, cytokine secretion, and natural cytolysis. We found that CD4+CD161- and CD8+CD161- subsets contained predominantly naive T cells that secreted high levels of IL-2
Neocortical neuronogenesis occurs in the pseudostratified ventricular epithelium (PVE) which forms the margin of the ventricular system of the embryonic cerebral wall. We have determined that in mouse the neuronogenetic interval continues 6 days and is divisible into 11 integer cycles. The fraction of daughter cells which leaves the cycle (Q) following a curvilinear path from 0 to 1.0 over the neuronogenetic interval. Q reaches 0.5 in the course of cell cycle 8 at which point the number of daugh
Open papers in the app to read, cite, and organize with AI.
