Won Keun Oh
Seoul National University 약학과 · 生化学・遺伝学・分子生物学
Won Keun Oh 교수의 연구실은 대사질환과 신경퇴행성질환의 예방 및 치료를 위한 천연물 기반 신약 개발에 초점을 맞추고 있습니다. 특히 약용식물에서 유래한 생활물질이 대사 조절 효소(AMPK, ACC2, PTP1B 등)를 타겟으로 하여 인슐린 감수성 향상, 지방산 산화 증가, 염증 반응 억제 등의 생리적 효과를 유도하는 메커니즘을 규명하고 있습니다. 또한, 해조류 유래 천연물의 항바이러스 작용과 항산화 활성에 대한 기초 연구도 병행하고 있습니다.
Figures are computed from collected data and may differ slightly.
Acc2-/- mutant mice, when fed a high-fat/high-carbohydrate (HF/HC) diet, were protected against diet-induced obesity and diabetes. To investigate the role of acetyl-CoA carboxylase 2 (ACC2) in the regulation of energy metabolism in adipose tissues, we studied fatty acid and glucose oxidation in primary cultures of adipocytes isolated from wild-type and Acc2-/- mutant mice fed either normal chow or a HF/HC diet. When fed normal chow, oxidation of [14C]palmitate in adipocytes of Acc2-/- mutant mic
Therapeutic approach of Alzheimer's disease (AD) has been gradually diversified. We examined the therapeutic and preventive potential of andrographolide, which is a lactone diterpenoid from <i>Andrographis paniculata</i>, and focused on the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor (erythroid-derived 2)-like 2 (Nrf2)-mediated heme oxygenase (HO)-1-inducing effects and the inhibitory activity of amyloid beta (A<i>β</i>)<sub>42</sub>-induced microglial activation related to Nrf2 a
<i>Ecklonia cava</i> is edible seaweed that is found in Asian countries, such as Japan and Korea; and, its major components include fucoidan and phlorotannins. Phlorotannins that are isolated from <i>E. cava</i> are well-known to have an antioxidant effect and strong antiviral activity against porcine epidemic diarrhea virus (PEDV), which has a high mortality rate in piglets. In this study, the bioactive components were determined based on two different approaches: (i) bio-guided isolation using
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