Sungkyunkwan University · 医学
Professor Won Sohn's research lab focuses on hepatology and metabolic liver diseases, with a strong emphasis on identifying novel biomarkers and risk prediction models for hepatocellular carcinoma (HCC) and hepatic fibrosis. The lab investigates the role of circulating microRNAs, especially exosomal microRNAs, in early detection of HCC among patients with chronic hepatitis B and nonalcoholic fatty liver disease (NAFLD). It also explores the impact of metabolic factors—such as obesity, insulin resistance, and zinc levels—on liver fibrosis progression, integrating clinical, molecular, and imaging-based approaches for risk stratification.
Figures are computed from collected data and may differ slightly.
Recent studies have shown that circulating microRNAs are a potential biomarker in various types of malignancies. The aim of this study was to investigate the feasibility of using serum exosomal microRNAs as novel serological biomarkers for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB). We measured the serum exosomal microRNAs and serum circulating microRNAs in patients with CHB (n=20), liver cirrhosis (LC) (n=20) and HCC (n=20). Serum exosomal microRNA was extracted f
High BMI increases liver cancer mortality and occurrence of primary liver cancer. Obesity is an independent risk factor for the occurrence of and mortality from primary liver cancer.
The study presents a new risk score model with a good ability to predict HCC development and determine high risk patients for HCC development consisting of readily available clinical factors in treatment-naïve CHB patients receiving entecavir.
Mast cells are activated leading to the raised levels of substance P & VIP in IBS-D patients. However, the correlation between mast cells and levels of substance P & VIP differs according to gender.
This study aimed to investigate the relationship between serum zinc level and hepatic fibrosis in patients with nonalcoholic fatty liver disease (NAFLD). A cross-sectional study was conducted using nationally representative samples from the Korea National Health and Nutrition Examination Survey 2010. Significant hepatic fibrosis was defined as Fibrosis-4 (FIB-4) index>1.3. Zinc level was measured using inductively coupled plasma mass spectrometry. Univariable and multivariable logistic regressio
The aim of this study was to assess the risk of liver fibrosis in those with no glucose intolerance, prediabetes, or diabetes. A cross-sectional study was conducted based on a cohort from a health examination program which included a magnetic resonance elastography (MRE). Participants were classified into three groups according to glucose tolerance: no glucose intolerance, prediabetes, and diabetes mellitus. Liver fibrosis was evaluated by liver stiffness measurement (LSM) value using two-dimens
Use of oral antiviral treatment after curative RF ablation was associated with favorable outcomes in terms of tumor recurrence and overall survival in patients with HBV-related HCC.
HCC surveillance using the national screening program in patients with chronic viral hepatitis or liver cirrhosis provides better opportunity for curative treatment for HCC and improves overall survival.
Tianeptine is not inferior to amitriptyline for treating IBS-D in terms of both efficacy and tolerability.
It is unclear whether the reactivation of hepatitis B virus (HBV) influences the prognosis of hepatocellular carcinoma (HCC) after resection in patients with chronic hepatitis B. The aim of this study was to identify the influence of HBV reactivation on the recurrence of hepatitis B-related HCC after curative resection in patients with low viral load (HBV DNA <2000 IU/mL). We retrospectively analysed a total of 130 patients who underwent curative resection for HBV-related early stage HCC (single
Purpose and scopeNonalcoholic fatty liver disease (NAFLD) is defined as excessive fat accumulation in the liver in the absence of significant alcohol consumption.Recently, a novel concept of fatty liver disease (FLD) has emerged.When the term 'nonalcoholic' was first introduced, the disease identity of NAFLD was based on the exclusion of other etiologies for chronic liver disease.However, the characteristics of NAFLD have gradually been established, as it is closely
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