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The development of functional scaffolds with improved osteogenic potential is important for successful bone formation and mineralization in bone tissue engineering. In this study, we developed a functional electrospun silk fibroin (SF) nanofibrous scaffold functionalized with two-stage hydroxyapatite (HAp) particles, using mussel adhesive-inspired polydopamine (PDA) chemistry. HAp particles were first incorporated into SF scaffolds during the electrospinning process, and then immobilized onto th

There are numerous sources of bioenergy that are generated by photosynthetic processes, for example, lipids, alcohols, hydrogen, and polysaccharides. However, generally only a small fraction of solar energy absorbed by photosynthetic organisms is converted to a form of energy that can be readily exploited. To more efficiently use the solar energy harvested by photosynthetic organisms, we evaluated the feasibility of generating bioelectricity by directly extracting electrons from the photosynthet

Abstract The rapid detection of biomolecule levels in the human body is often required to monitor human health. Although swellable microneedle arrays are widely used to extract biomolecules in interstitial fluid in a minimally invasive manner, it takes 3–15 min to carry this out. Herein, we report the development of a microneedle sensor system for the rapid detection of biomolecules. By controlling the crosslinking sequence of methacrylated hyaluronic acid (MeHA) used in the microneedle array, w

Abstract Detachable microneedle (MN) technology is highly desired for treatment of ocular diseases such as keratitis or glaucoma because of its minimally invasiveness and sustained drug delivery. However, shortening of administration time during insertion into target tissues still remains an important issue, although various approaches using mechanical and chemical separation mechanisms have been attempted. Here, a rapidly detachable microneedle pen (RD‐MNP) containing a porous dissolvable sacri

Microneedle (MN) sensing of biomarkers in interstitial fluid (ISF) can overcome the challenges of self-diagnosis of diseases by a patient, such as blood sampling, handling, and measurement analysis. However, the MN sensing technologies still suffer from poor measurement accuracy due to the small amount of target molecules present in ISF, and require multiple steps of ISF extraction, ISF isolation from MN, and measurement with additional equipment. Here, we present a swellable MN-mounted nanogap