Korea University · 医学
Professor Woo Young Jang's research lab focuses on developing advanced biomaterials and molecular diagnostics for improving clinical outcomes in orthopedic surgery and chronic disease management. The lab specializes in creating bioinspired, anti-infective coatings for orthopedic implants—such as the lubricated orthopedic implant surface (LOIS)—to prevent post-surgical infections and enhance implant longevity. Additionally, the lab pioneers non-invasive, topical mRNA nanosensors (NanoFlare) for real-time monitoring of wound healing and tissue repair at the molecular level. The research also explores the clinical implications of metabolic and nutritional factors, such as vitamin D deficiency and underweight status, in neurodegenerative diseases like Parkinson’s disease.
Figures are computed from collected data and may differ slightly.
Bacterial infection and infection-induced immune response have been a life-threatening risk for patients having orthopedic implant surgeries. Conventional biomaterials are vulnerable to biocontamination, which causes bacterial invasion in wounded areas, leading to postoperative infection. Therefore, development of anti-infection and immune-evasive coating for orthopedic implants is urgently needed. Here, we developed an advanced surface modification technique for orthopedic implants termed lubri
Being underweight and diabetes mellitus were associated with an increased risk of PD incidence, and effect of being underweight was more prominent in those with diabetes mellitus, with a dose-response relationship existing according to diabetes mellitus status. Further research is warranted to understand the clinical implications of the significant interaction between being underweight and diabetes mellitus status in the development of PD. © 2020 International Parkinson and Movement Disorder Soc
Level IV, therapeutic case series.
An effective wound management strategy needs accurate assessment of wound status throughout the whole healing process. This can be achieved by examining molecular biomarkers including proteins, DNAs, and RNAs. However, existing methods for quantifying these biomarkers such as immunohistochemistry and quantitative polymerase chain reaction are usually laborious, resource-intensive, and disruptive. This article reports the development and utilization of mRNA nanosensors (i.e., NanoFlare) that are
Although the underlying mechanism for this association is not fully understood, our results suggest that low vitamin D status is associated with OH in patients with PD.
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