東京大学 · 医学
岸本康史教授の研究室は、頸椎症性 myelopathy（CSM）の病態メカニズムと予後因子の解明を柱としています。特に、臨床的軽症例の長期予後や神経機能評価の指標としてのPRO-JOAスコアの有効性を検証しており、画像所見と臨床症状の乖離についても注力しています。また、軟骨内骨化過程におけるチタン酸イオン（P(i)）が誘導する好酸球芽細胞のアポトーシス機構の解明にも取り組んでいます。
Figures are computed from collected data and may differ slightly.
Fifty-six percent of patients with clinically mild CSM with ISI had not deteriorated or undergone surgery at 10 years. Large range of motion, segmental kyphosis, and instability at the narrowest canal were considered to be adverse prognostic factors.
PRO-JOA score can also be used as a disease-specific scoring measure instead of JOA score. However, although both measures demonstrate a similar trend as a group analysis, PRO-JOA and JOA scores should be regarded as different outcomes.
During endochondral ossification, chondrocytes undergo hypertrophic differentiation and die by apoptosis. The level of inorganic phosphate (P(i)) elevates at the site of cartilage mineralization, and when chondrocytes were treated with P(i), they underwent rapid apoptosis. Gene silencing of the proapoptotic Bcl-2 homology 3-only molecule bnip3 significantly suppressed P(i)-induced apoptosis. Conversely, overexpression of Bcl-xL suppressed, and its knockdown promoted, the apoptosis of chondrocyte
3.
Patients with a low mental state, possibly before surgery, are at a high risk for postoperative axial neck pain. None of the imaging parameters were statistically different.
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