The University of Tokyo · Biochemistry, Genetics and Molecular Biology
카마타니 교수의 연구실은 인구 기반 게놈 연관 연구(GWAS)를 바탕으로 고혈압, 만성질환 등 복합적 질병의 유전적 기반을 규명하는 데 초점을 맞추고 있습니다. 특히 알코올 소비와 유전자의 상호작용이 혈압 조절에 미치는 영향을 탐색하는 고도화된 유전체 분석 기법을 개발·적용하고 있으며, 다양한 인구집단(특히 일본인)을 대상으로 한 대규모 유전체 데이터를 기반으로 유전자-표현형의 다중적 연관성과 세포 유형 특이성을 규명하고 있습니다.
Figures are computed from collected data and may differ slightly.
Heavy alcohol consumption is an established risk factor for hypertension; the mechanism by which alcohol consumption impact blood pressure (BP) regulation remains unknown. We hypothesized that a genome-wide association study accounting for gene-alcohol consumption interaction for BP might identify additional BP loci and contribute to the understanding of alcohol-related BP regulation. We conducted a large two-stage investigation incorporating joint testing of main genetic effects and single nucl
Clinical measurements can be viewed as useful intermediate phenotypes to promote understanding of complex human diseases. To acquire comprehensive insights into the underlying genetics, here we conducted a genome-wide association study (GWAS) of 58 quantitative traits in 162,255 Japanese individuals. Overall, we identified 1,407 trait-associated loci (P < 5.0 × 10<sup>-8</sup>), 679 of which were novel. By incorporating 32 additional GWAS results for complex diseases and traits in Japanese indiv
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