名古屋大学 · 医学
石塚陽治教授の研究室では、自己免疫性肝炎やIgG4関連疾患をはじめとする自己免疫性肝疾患の病態解明と診断・治療法の確立を主な研究テーマとしています。特に、IgG4関連性自己免疫性肝炎やIgG4肝症の臨床像・病理像の解明に注力しており、全身性自己免疫疾患におけるIgG4の役割を解き明かしています。また、ウイルス性肝炎に伴う造血障害や脾機能亢進のメカニズムについても、治療反応と関連して研究を進めています。
Figures are computed from collected data and may differ slightly.
Immunoglobulin G4-related disease (IgG4-RD) is a systemic disease involving many organs; it includes IgG4-related sclerosing cholangitis and inflammatory pseudotumor in the hepatobiliary system. Two types of hepatic parenchymal involvement have been reported in IgG4-RD: IgG4-related autoimmune hepatitis (AIH) and IgG4-hepatopathy. Moreover, only three cases of IgG4-related AIH have been reported. Immunoglobulin G4-related AIH is clinicopathologically similar to AIH, except for an elevated serum
Immunoglobulin G4 (IgG4)-associated autoimmune hepatitis (AIH) is a new disease entity with elevated levels of serum IgG4 and marked IgG4 positive plasma cell infiltration of the liver, and its clinical course remains unknown. A patient with IgG4-associated AIH who later developed autoimmune pancreatitis (AIP) is reported. A 73-year-old man was admitted to our hospital due to elevated liver transaminase levels, hypergammaglobulinemia and positive antinuclear antibody. A liver biopsy specimen sho
Platelet counts increased at 4 weeks after starting anti-HCV treatment. Our results suggest that this rapid change was possibly caused by improvement of hypersplenism and HCV-induced myelosuppression resulting from anti-HCV therapy.
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