Hanyang University · 生化学・遺伝学・分子生物学
Professor Yong-Hee Kim's research lab specializes in the development of advanced drug delivery systems for treating metabolic disorders, cancer, and inflammatory diseases. The lab focuses on designing smart, biocompatible nanocarriers—such as peptide-based polyplexes, microneedle patches, and hybrid nanoparticles—that enable targeted, efficient, and stimuli-responsive delivery of therapeutic agents. Key research directions include gene delivery using self-assembled oligopeptoplexes, targeted delivery of HO-1 modulators to adipose tissue and leukemia microenvironments, and the application of 3D-printed microneedles for precise transcutaneous drug administration. The lab integrates principles of biomaterials, molecular targeting, and nanomedicine to overcome biological barriers and improve therapeutic outcomes.
Figures are computed from collected data and may differ slightly.
Nonarginine (D-R9) has been reported to be one of the most efficacious protein transduction domains (PTDs) for the intracellular cargo delivery such as DNA, RNA, proteins, and particles. Although oligoarginines are capable of forming polyplex with DNA by electrostatic interaction, the length of oligoarginine can affect the toxicity and gene expression. The reducible poly(oligo-D-arginine) (rPOA) composed of the Cys-(D-R9)-Cys repeating unit forming disulfide bonds between terminal cysteinyl-thio
Advancements in micro-resolution 3D printers have significantly facilitated the development of highly complex mass-producible drug delivery platforms. Conventionally, due to the limitations of micro-milling machineries, dissolvable microneedles (MNs) are mainly fabricated in cone-shaped geometry with limited drug delivery accuracy. Herein, to overcome the limitations of conventional MNs, a novel projection micro-stereolithography 3D printer-based self-locking MN for precise skin insertion, adhes
Abstract Nanoparticular drug delivery systems may help to overcome the limitations of conventional chemotherapy. They have been reported to improve the specificity of distribution, the bioavailability, and the solubility of drugs, as well as the duration of drug efficacy, and helping to overcome multidrug resistance. Although various polymeric nanoparticles have been developed for delivery of anticancer agents, most nanoparticles still focus on solubilizing drugs, improving targeting ability, an
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