The University of Osaka · 医学
Matsuura教授の研究室では、ウイルス関連疾患の発症機構と治療戦略の解明を柱として、ヘパチティスCウイルス（HCV）やSARS-CoV-2の病原性メカニズムを分子・細胞生物学的手法を用いて解明しています。特にHCVのコアタンパク質と宿主因子（PA28γ）の相互作用が脂肪肝や肝細胞癌の発症に与える影響を解析しており、ウイルス病態の分子基盤を解明しています。また、ウイルスの遺伝子操作技術の開発や、遺伝子導入ベクターの改良（バキュロウイルスベクター）にも取り組んでいます。
Figures are computed from collected data and may differ slightly.
Hepatitis C virus (HCV) is a major cause of chronic liver disease that frequently leads to steatosis, cirrhosis, and eventually hepatocellular carcinoma (HCC). HCV core protein is not only a component of viral particles but also a multifunctional protein because liver steatosis and HCC are developed in HCV core gene-transgenic (CoreTg) mice. Proteasome activator PA28gamma/REGgamma regulates host and viral proteins such as nuclear hormone receptors and HCV core protein. Here we show that a knocko
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been identified as the causative agent of coronavirus disease 2019 (COVID-19). Although multiple mutations have been observed in SARS-CoV-2, functional analysis of each mutation of SARS-CoV-2 has been limited by the lack of convenient mutagenesis methods. In this study, we establish a PCR-based, bacterium-free method to generate SARS-CoV-2 infectious clones. Recombinant SARS-CoV-2 could be rescued at high titer with high accuracy a
Although recombinant baculovirus vectors can be an efficient tool for gene transfer into mammalian cells in vitro, gene transduction in vivo has been hampered by the inactivation of baculoviruses by serum complement. Recombinant baculoviruses possessing excess envelope protein gp64 or other viral envelope proteins on the virion surface deliver foreign genes into a variety of mammalian cell lines more efficiently than the unmodified baculovirus. In this study, we examined the efficiency of gene t
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