Yoshihiro Kamada

Recent studies indicate an accelerated progression of nonalcoholic steatohepatitis (NASH) in postmenopausal women. Hypercholesterolemia, an important risk factor for NASH progression, is often observed after menopause. This study examined the effects of estrogen on NASH in ovariectomized (OVX) mice fed a high-fat and high-cholesterol (HFHC) diet. To investigate the effects of estrogen deficiency, OVX mice and sham-operated (SO) mice were fed normal chow or HFHC diet for 6 wk. Next, to investigat

In JT-60U H-mode plasmas, giant (type I) ELMs disappear and minute grassy ELMs appear when triangularity δ, edge safety factor q95 and βp are high enough. Complete suppression of giant ELMs was observed at δ≳0.45, q95≳6 and βp≳1.6. At higher δ (0.54), giant ELMs can disappear at a lower q95 (~4.0). In the grassy ELMy H-mode, edge temperature and pressure can be higher than those in giant ELMy H-mode and a favourable confinement can be sustained without an increase of the impurity concentration.

The JT-60SA device has been designed as a highly shaped large superconducting tokamak with a variety of plasma actuators (heating, current drive, momentum input, stability control coils, resonant magnetic perturbation coils, W-shaped divertor, fuelling, pumping, etc) in order to satisfy the central research needs for ITER and DEMO. In the ITER- and DEMO-relevant plasma parameter regimes and with DEMO-equivalent plasma shapes, JT-60SA quantifies the operation limits, plasma responses and operatio

With the main aim of providing the physics basis for ITER and steady state tokamak reactors, JT-60U has been optimizing operational concepts and extending discharge regimes towards simultaneous sustainment of high confinement, high βN, high bootstrap fraction, full non-inductive current drive, and efficient heat and particle exhaust utilizing a variety of heating, current drive, torque input and particle control capabilities. In the two advanced operation regimes (reversed magnetic shear (RS mod

With the high-field-side multiple pellet injection into high-triangularity high-βp type I ELMy H-mode discharges, JT-60U has extended the density range with a favourable integrated performance. The pellet injected discharge has a high pedestal pressure compared with the gas fuelled discharges, and the pedestal temperature does not decrease even at high pedestal density. At high triangularity, the pedestal βp and the edge α-parameter increase with increasing total βp. Possible linkage among pedes

The JT-60SA project implemented by Japan and Europe is progressing on schedule towards the first plasma in March 2019. After careful R&D, procurements of the major components have entered their manufacturing stages. In parallel, disassembly of JT-60U has been completed on time, and the JT-60SA tokamak assembly is expected to start in January 2013. The JT-60SA device, a highly shaped large superconducting tokamak with a variety of plasma control actuators, has been designed in order to contri

Although L-arginine is the only substrate for nitric oxide (NO) production, no studies have yet been reported on the effect of an L-arginine deficiency on vascular function in humans. Lysinuric protein intolerance (LPI) is a rare autosomal recessive defect of dibasic amino acid transport caused by mutations in the SLC7A7 gene, resulting in an L-arginine deficiency. Vascular endothelial function was examined in an LPI patient who was shown to be a compound heterozygote for two mutations in the ge

Although L-arginine is the only substrate for nitric oxide (NO) production, no studies have yet been reported on the effect of an L-arginine deficiency on vascular function in humans. Lysinuric protein intolerance (LPI) is a rare autosomal recessive defect of dibasic amino acid transport caused by mutations in the SLC7A7 gene, resulting in an L-arginine deficiency. Vascular endothelial function was examined in an LPI patient who was shown to be a compound heterozygote for two mutations in the ge

The article treats the recent development of quasi-steady ELMy high βp H mode discharges with enhanced confinement and high β stability, where long sustainment time, an increase in absolute fusion performance and extension of the discharge regime towards low q95 (∼3) are emphasized. After modification to the new W shaped pumped divertor, a long heating time (9 s) with a high total heating energy input of 203 MJ became possible without a harmful increase in impurity and particle recycling. In add