名古屋大学 · 医学
Yoshihisa Matsukawa教授の研究室は、前立腺疾患に伴う下部尿路症状（LUTS）の病態メカニズムと治療戦略を、尿動学的・臨床的アプローチを通じて解明しています。特に、良性前立腺症やラミノスコピック根治的前立腺ectomy後の膀胱機能低下、特に新生の逼尿筋運動低下や過活動膀胱の発症メカニズムに注目しています。また、シロドシンやタダラフィルを用いた薬理療法の有効性を、客観的尿動学的指標に基づき評価しており、臨床応用に結びつく革新的な治療戦略の確立を目指しています。
Figures are computed from collected data and may differ slightly.
Silodosin improved lower urinary tract symptoms by improving bladder storage function and relieving benign prostatic obstruction.
Silodosin improved lower urinary tract symptoms by improving bladder storage function and relieving benign prostatic obstruction.
Objective: The aim of this study was to investigate bladder function following laparoscopic radical prostatectomy, with a focus on de novo detrusor underactivity. Methods: Records on pre‐ and postoperative urodynamic studies were retrospectively investigated in 110 patients who underwent laparoscopic radical prostatectomy. Patients exhibiting de novo detrusor underactivity were selected on the basis of an overt strain voiding pattern during the postoperative pressure flow study with detrusor pre
The incidence rate of de novo OAB after RARP was about 40%, and seemed unexpectedly high. Decreased urethral function was significantly related to de novo OAB after surgery.
Objective To investigate the clinical characteristics and useful signs to differentiate detrusor underactivity from bladder outlet obstruction in men with non‐neurogenic lower urinary tract symptoms. Methods A total of 638 treatment‐naive men with non‐neurogenic lower urinary tract symptoms who underwent subjective and objective evaluations were reviewed retrospectively. We divided the patients into detrusor underactivity and bladder outlet obstruction groups based on urodynamic findings, and co
Treatment with tadalafil 5 mg once daily effectively relieves lower urinary tract symptoms based on objective improvement of storage and voiding function, such as detrusor overactivity and bladder outlet obstruction, in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia.
Aims To compare the efficacy of fesoterodine or mirabegron add‐on therapy for persistent overactive bladder (OAB) symptoms despite silodosin monotherapy in men with lower urinary tract symptoms suggestive of benign prostatic hyperplasia, in both subjective and objective aspects. Methods A total of 120 patients with persistent OAB symptoms despite silodosin monotherapy were randomized to receive add‐on therapy with fesoterodine (4 mg/day) or mirabegron (50 mg/day) for 12 weeks. At week 12, change
Dutasteride is effective in relieving lower urinary tract symptoms by improving storage and voiding function, as well as subjective symptoms in patients with benign prostatic hyperplasia.
Purpose: Some patients who undergo robot-assisted laparoscopic radical prostatectomy (RARP) continue to experience long-term urinary incontinence (UI). This study aimed to evaluate easily obtainable factors that can predict long-term UI following RARP. Materials and Methods: A total of 315 patients who underwent RARP for localized prostatic cancer were analyzed. We separated the patients into two groups, namely, the Continence group and the Incontinence group, according to the presence or absenc
Silodosin, a pure α1A-adrenoceptor blocker, showed greater improvement in overactive bladder symptoms along with the urinary flow rate in patients with benign prostatic enlargement complicated by overactive bladder compared to naftopidil, an α1D>A-adrenoceptor blocker.
Long-term combination treatment with silodosin and propiverine was effective and safe for BPE patients with voiding and OAB symptoms. Neurourol. Urodynam. 36:748-754, 2017. © 2016 Wiley Periodicals, Inc.
We found that α1-blocker withdrawal from combination therapy was reasonable and tolerable with regard to the effect on lower urinary tract symptoms and bladder outlet obstruction. However, withdrawal must be performed carefully in patients with a high body mass index.
Laparoscopic radical prostatectomy has a negative impact on storage function by impairing function of the urethral sphincter and decreasing bladder compliance. There is no difference in postoperative urethral function between open and laparoscopic radical prostatectomy. Laparoscopic surgery might be associated with less impairment of bladder function than open surgery.
Parameters on the first peak flow of UFM, especially the ratio of the first peak flow rate to Q<sub>max</sub> , can diagnose DU with high accuracy in men with LUTS.
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