京都大学 · 生化学・遺伝学・分子生物学
玉倉善信教授の研究室では、がん治療を目的としたドラッグデリバリー技術の開発に注力しています。特に、静脈内や筋内投与によるリンパ球への効率的で持続的な薬物送達を実現するための高分子プロドラッグや、細胞膜透過性を制御するハイドロダイナミクス的遺伝子送達法のメカニズム解明を進めています。これにより、がんの局所治療や免疫療法への応用が期待されています。
Figures are computed from collected data and may differ slightly.
These findings suggest that the mechanism for the hydrodynamics-based gene transfer would involve in part the direct cytosolic delivery of pDNA through the cell membrane due to transiently increased permeability.
Absorption and lymphatic transfer of a polymeric prodrug of mitomycin C (MMC), mitomycin C-dextran conjugate (MMC-D), following i.m. injection were studied in rats in order to assess the feasibility of a macromolecular prodrug as a lymphotropic delivery system. Three types of MMC-D, conjugates with dextran with molecular weights of 10,000, 70,000 and 500,000, were synthesized, and the disposition of MMC was determined by bioassay. Following i.m. injection of MMC-D, MMC was retained at the inject
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