Youngho Kim

Genetic alterations occur during the adenoma-carcinoma sequence of colon cancer formation and drive the initiation and progression of colon cancer formation. The aberrant methylation of genes is an alternate, epigenetic mechanism for silencing tumor suppressor genes in colon cancer. The aim of this study was to determine on a global and gene-specific level the role of CpG island methylation in the initiation and progression of colon cancer. Consequently, we assessed the frequency of gene methyla

Patent text is a rich source to discover technological progresses, useful to understand the trend and forecast upcoming advances. For the importance in mind, several researchers have attempted textual-data mining from patent documents. However, previous mining methods are limited in terms of readability, domain-expertise, and adaptability. In this paper, we first formulate the task of technological trend discovery and propose a method for discovering such a trend. We complement a probabilistic a

In this study, pre-impact fall detection algorithms were developed based on data gathered by a custom-made inertial measurement unit (IMU). Four types of simulated falls were performed by 40 healthy subjects (age: 23.4 ± 4.4 years). The IMU recorded acceleration and angular velocity during all activities. Acceleration, angular velocity, and trunk inclination thresholds were set to 0.9 g, 47.3°/s, and 24.7°, respectively, for a pre-impact fall detection algorithm using vertical angles (VA algorit

We developed an active ankle-foot orthosis (AAFO) that controls dorsiflexion/plantarflexion of the ankle joint to prevent foot drop and toe drag during hemiplegic walking. To prevent foot slap after initial contact, the ankle joint must remain active to minimize forefoot collision against the ground. During late stance, the ankle joint must also remain active to provide toe clearance and to aid with push-off. We implemented a series elastic actuator in our AAFO to induce ankle dorsiflexion/plant

Fall-related injury is a common cause of mortality among the elderly. Hip fractures are especially dangerous and can even be fatal. In this study, a threshold-based preimpact fall detection algorithm was developed for wearable airbags that minimize the impact of falls on the user's body. Acceleration sum vector magnitude (SVM), angular velocity SVM, and vertical angle, calculated using inertial data captured from an inertial measurement unit were used to develop the algorithm. To calculate the v

In this study, a pre-impact fall detection algorithm using a custom-made inertial sensor was optimized, and a spring-trigger airbag system was developed for preventing injuries from falls. Four different types of simulated falls were performed by 20 healthy volunteers (age 23.4 4.4 years), and six different daily activities were tested in 14 elderly subjects (age 71.8 4.0 years). An inertial sensor unit was used to measure acceleration, angular velocity, and vertical angle during all activities.

The present study was performed to investigate the effect on the skin and the intra-articular structures of 5-minutes of cold air application. During and after 5 minutes of cold air application on 20 healthy subjects, the skin and intra-articular temperatures were measured by means of an infrared thermogram and a digital k-wire probe, respectively. The results showed that 1) Skin temperature dropped very rapidly by a total of 22.1 degrees C after 5 minutes of cold air application. 2) Intra-artic

Many safety accidents can occur in industrial sites. Among them, falls from heights (FFHs) are the most frequent accidents and have the highest fatality rate. Therefore, some existing studies have developed personal wearable airbags to mitigate the damage caused by FFHs. To utilize these airbags effectively, it is essential to detect FFHs before collision with the floor. In this study, an inertial measurement unit (IMU) sensor attached to the seventh thoracic vertebrae (T7) was used to develop a

Workers at construction sites are prone to fall-from-height (FFH) accidents. The severity of injury can be represented by the acceleration peak value. In the study, a risk prediction against FFH was made using IMU sensor data for accident prevention at construction sites. Fifteen general working movements (NF: non-fall), five low-hazard-fall movements, (LF), and five high-hazard-FFH movements (HF) were performed by twenty male subjects and a dummy. An IMU sensor was attached to the T7 position o

Large differences between the concentrations of serum total carbon dioxide (TCO2) and blood gas bicarbonate (HCO3 (-)) were observed in two consecutive simultaneously drawn sets of samples of serum and arterial blood gases in a patient who presented with severe carbon dioxide retention and profound acidemia. These differences could not be explained by the effect of the high partial pressure of carbon dioxide on TCO2, by variations in the dissociation constant of the carbonic acid/bicarbonate sys

As the number of classifiers (1 to 8) and size of training data (50 to 300) increased, the average accuracy of the E-ANN-based classifier increased and the standard deviation decreased. The optimal E-ANN was composed with eight classifiers and 300 size of training data, and the accuracy of the E-ANN was significantly higher than that of the general ANN.