京都大学 · 医学
中野健二教授の研究室は、PET・CT画像の定量的解析と臨床応用に焦点を当てた核医学・画像診断学の研究を推進しています。特に、FDG-PETにおける腫瘍と正常組織の代謝活動の差異解明や、画像定量値の正確性を高めるためのアーティファクト低減技術の開発が主な研究テーマです。また、がんの再発モニタリングや臓器特異的代謝パターンの解明を通じて、がん診断の精度向上に貢献しています。
Figures are computed from collected data and may differ slightly.
Intense FDG uptake was usually observed in the palatine tonsils, lingual tonsils, and soft palate, whereas uptake in the major salivary glands was variable.
The current data suggest that delayed FDG-PET scanning at 2 hours postinjection may contribute to differentiation between malignant and benign lesions in the pancreas.
Although quantitative radioactivity values are generally comparable between CT- and germanium-corrected emission PET images, CT-based attenuation correction produced radioactivity concentration values significantly higher than the germanium-based corrected values. These effects, especially in radiodense tissues, should be noted when using and comparing quantitative PET analyses from PET and PET/CT systems.
Our preliminary data suggest that whole-body PET with FDG can be a complementary modality for following up patients who have had ovarian cancer, especially patients believed to be at risk for recurrence.
High concentrations of a contrast agent caused considerable overestimation of apparent tracer activity in phantom studies; however, the emission bias was relatively modest in vivo, except in areas with very high contrast agent concentrations.
PURPOSE: To retrospectively evaluate lesion findings at computed tomography (CT) performed as part of a combined positron emission tomography (PET)/CT examination in patients suspected of having metastatic bone lesions—lesions that were detected with fluorine 18 fluorodeoxyglucose (FDG) PET as part of the same examination—and to correlate the CT and FDG PET findings. MATERIALS AND METHODS: This HIPAA-compliant study had institutional review board approval, and the need for patient informed conse
Our preliminary data indicate that NIS-based gene therapy may be applied by concentrating a lethal dose of radiation in tumor cells in vivo, but further investigation is necessary to determine a method of maintaining radioiodine in the cells to allow greater therapeutic effects.
The most frequent pattern of detectable bone metastases with FDG-PET imaging was multiple foci of intense uptake. PET revealed more lesions than did bone scanning, independent of the type of cancer or location of bone involvement, in patients who were accurately diagnosed by FDG-PET imaging.
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