京都大学 · 工学
Kitazumi教授の研究室では、酵素と電極の直接的な電子移動（DET）を実現するためのナノ構造電極の設計と、酵素のタンパク質工学的改変を組み合わせたバイオエレクトロケミストリーの研究を行っています。特に膜貫通型アルデヒド脱水素酵素を用いた酸化還元反応のメカニズム解明や、反応の方向性制御に注力しており、エネルギー変換やセンシング応用に向けた基盤技術の構築を目指しています。
Figures are computed from collected data and may differ slightly.
Direct electron transfer (DET)-type bioelectrocatalysis, which couples the electrode reactions and catalytic functions of redox enzymes without any redox mediator, is one of the most intriguing subjects that has been studied over the past few decades in the field of bioelectrochemistry. In order to realize the DET-type bioelectrocatalysis and improve the performance, nanostructures of the electrode surface have to be carefully tuned for each enzyme. In addition, enzymes can also be tuned by the
The adsorption of decylsulfate (DeSO4(-)) and decylammonium (DeNH(3+)) at the 1,2-dichloroethane (DCE)|water(W) interface has been examined as a function of the phase-boundary potential by simultaneous recording of electrocapillary curves and voltammograms. The standard Gibbs energies for the adsorption of DeSO(4)(-) and DeNH(3)(+) at the DCE|W interface from the W phase depend linearly on the phase-boundary potential, having the slopes of 9.1 and-9.8 kJ mol-1 V-1, respectively. These values sug
The bioelectrocatalytic properties of membrane-bound aldehyde dehydrogenase (AlDH) from Gluconobacter oxydans NBRC12528 were evaluated. AlDH exhibited direct electron transfer (DET)-type bioelectrocatalytic activity for acetaldehyde oxidation at several kinds of electrodes. The kinetic and thermodynamic parameters for bioelectrocatalytic acetaldehyde oxidation were estimated based on the partially random orientation model. Moreover, at the multi-walled carbon nanotube-modified electrode, the coo
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