大阪大学 · 生化学・遺伝学・分子生物学
Akeda教授の研究室は、細菌の病原性機構、特にタイプIII分泌系の分子機構と耐性メカニズムに焦点を当てた研究を推進しています。SalmonellaのInvC ATPアーゼの機能的ドメイン同定や、メタロ-β-ラクタマーゼを有する耐性菌の遺伝的特性解明を通じて、感染症のメカニズム解明と新たな治療戦略の開発を目指しています。特に、臨床的意義の高い耐性菌の出現と拡散のメカニズム解明が重要な研究テーマです。
Figures are computed from collected data and may differ slightly.
An essential component of all type III secretion systems is a highly conserved ATPase that shares significant amino acid sequence similarity to the beta subunit of the F(0)F(1) ATPases and is thought to provide the energy for the secretion process. We have performed a genetic and functional analysis of InvC, the ATPase associated with the Salmonella enterica type III secretion system encoded within its pathogenicity island 1. Through a mutagenesis analysis, we have identified amino acid residues
The bacterial enzyme New Delhi metallo-β-lactamase hydrolyzes almost all β-lactam antibiotics, including carbapenems, which are drugs of last resort for severe bacterial infections. The spread of carbapenem-resistant Enterobacteriaceae that carry the New Delhi metallo-β-lactamase gene, blaNDM, poses a serious threat to public health. In this study, we genetically characterized eight carbapenem-resistant Escherichia coli isolates from a tertiary care hospital in Yangon, Myanmar. The eight isolate
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