The University of Osaka · 医学
Umemura教授の研究室は、感染症・敗血症における病原体の疫学的特徴と最適な抗菌療法の確立を目指しており、特に敗血症の早期対応と血管内皮障害のメカニズム解明に注力しています。COVID-19に伴う凝固異常の特徴や、熱ショックモデルにおける骨髄由来単核球の治療的効果についての革新的な研究が進められています。臨床的応用に直結する実践的で革新的な研究が特徴です。
Figures are computed from collected data and may differ slightly.
This study revealed the current spectrum of pathogens and its variation based on the site of infection, which is essential for empiric antimicrobial therapy against sepsis.
Therapeutic/care management, level IV.
The hematological phenotype of COVID-19-induced coagulopathy is quite different from that in typical SIC characterized by systemic hypercoagulation and suppressed fibrinolysis. Instead, local thrombus formation might be promoted in severe COVID-19.
Completion of the hour-1 bundle was associated with lower in-hospital mortality. Obtaining blood cultures and administering antibiotics within 1 hour may have been the components most contributing to decreased in-hospital mortality.
Transplantation of BMMNCs attenuated acute systemic inflammation and vascular endothelial injury, reduced organ dysfunction, and improved survival in a rat heatstroke model. These findings provide a possible therapeutic strategy against critical heatstroke.
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