九州大学 · 医学
Zulvikar Syambani Ulhaq教授の研究室は、神経発達と神経炎症の分子メカニズムに焦点を当てた研究を推進しています。特に、ゾウリムフィッシュをモデルとして脳内エストロゲン産生酵素（AroB）の神経新生への影響を解明しており、セロトニン作動性ニューロンの発達と内分泌系の相互作用を解明しています。また、炎症関連遺伝子の多形性と神経疾患（パーキンソン病など）や眼疾患との関連についても、メタアナリシスや遺伝子型-フェノタイプ相関解析を通じて体系的な研究を実施しています。
Figures are computed from collected data and may differ slightly.
Teleost fish are known to express two isoforms of P450 aromatase, a key enzyme for estrogen synthesis. One of the isoforms, brain aromatase (AroB), <i>cyp19a1b</i>, is highly expressed during early development of zebrafish, thereby suggesting its role in brain development. On the other hand, early development of serotonergic neuron, one of the major monoamine neurons, is considered to play an important role in neurogenesis. Therefore, in this study, we investigated the role of AroB in developmen
Interleukin-6 (IL-6) is one of the key regulators behind the inflammatory and pathological process associated with ophthalmic diseases. The role of IL-6-174 G/C polymorphism as well as intraocular IL-6 levels among various eye disease patients differ across studies and has not been systematically reviewed. Thus, this study aims to provide a summary to understand the relationship between IL-6 and ophthalmic disease. In total, 8,252 and 11,014 subjects for IL-6-174 G/C and intraocular levels of IL
Treacher Collins syndrome (TCS, OMIM: 154500) is a rare congenital craniofacial disorder that is caused by variants in the genes TCOF1, POLR1D, POLR1C, and POLR1B. Studies on the association between phenotypic variability and their relative variants are very limited. This systematic review summarized the 53 literatures from PubMed and Scopus to explore the potential TCS genotype-phenotype correlations with statistical analysis. Studies reporting both complete molecular genetics and clinical data
Anxiety symptoms and disorders are common problems associated with ophthalmic disease patients. Thus, comprehensive and appropriate treatments are necessary for treating anxiety symptoms and disorders among ophthalmic disease patients.
Abstract Background Strong evidence supports the involvement of inflammation processes in the development and progression of Parkinson’s disease (PD), where increasingly correlations have been identified between genetic variations in inflammation-related genes and PD. However, data varies between studies. Therefore, we conducted a meta-analysis to clarify associations between inflammation-related gene polymorphisms and PD risk. Methods All studies were identified through online databases. Pooled
The balance between IL-6 and IL-10 serum levels is potentially useful in discriminating POAG severity.
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