한아람 교수
Aram Han
서울대학교 · 의학
연구실 소개
한아람 교수의 연구실은 이식 및 암 치료 분야에서 환자의 치료 이행도 향상과 정밀의료를 위한 혁신적 접근을 연구하고 있습니다. 특히 신장 이식 환자의 면역억제제 복용 이행도와 타크롤리무스 농도 변동성의 관계, 암 환자의 보조 치료 후 림프절 생검의 정확성 등 임상적 실용성을 중심으로 한 연구를 진행하고 있습니다. 또한 고위험군에서의 암 발생 위험 요소 분석과 수술적 치료 전략의 최적화를 통해 환자 중심의 맞춤형 치료 체계 구축을 목표로 하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15The Adhere4U application did not improve adherence to immunosuppressive therapy. Our evidence is limited by the high rate of attrition. Further studies on strategies to facilitate patient engagement with mobile interventions are warranted.
Despite important ART-related declines in KS incidence, men and women in South Africa and men who have sex with men remain at increased KS risk, likely due to high human herpesvirus 8 coinfection rates. Early ART initiation and maintenance of high CD4 cell counts are essential to further reducing KS incidence worldwide, but additional measures might be needed, especially in Southern Africa.
For the modern practice of cancer surgery, the concept of oncovascular surgery (OVS), defined as cancer resection with concurrent ligation or reconstruction of a major vascular structure, can be very important. OVS for advanced cancers requires specialized procedures performed by a specialized multidisciplinary team. Roles of oncovascular surgeons are summarized as: a primary surgeon in vesselorigin tumors, a rescue surgeon treating complications during cancer surgery, and a consultant surgeon a
This study analyzed the association between medication adherence and the intrapatient variability (IPV) of tacrolimus concentrations among kidney transplant recipients through a post hoc analysis of the dataset from a recently conducted randomized controlled trial. Among 138 patients enrolled in the original trial, 92 patients with ≥ 5 months of medication event monitoring system (MEMS) use and ≥ 4 tacrolimus trough values were included in this post hoc analysis. The variability of tacrolimus tr
The identification rate of SLNB and the accuracy of intraoperative frozen section examination after NAC are comparable to the results without NAC in patients with early breast cancer. However considering the high false negative rates, general application of SLNB after NAC should be avoided. Patients with progesterone-positive tumors and non-triple-negative breast cancers may be a select group of patients in whom SLNB can be employed safely after NAC, but further studies are necessary.
Postoperative routine duplex surveillance failed to prove superiority compared with selective duplex after physical examination for reducing arteriovenous fistula maturation failure. However, the wide 95% confidence interval for the effect of intervention precludes a firm conclusion that routine duplex surveillance was not beneficial.
We have shown that mouse liver contains enzymes that catalyze the conversion of the ketol side chain to the 20-hydroxy-21-oic acid side chain. In this paper, we have studied the oxidative metabolism of corticosterone to acidic end products in intact mice. A significant fraction of radioactivity from intraperitoneal injections of [4-14C]corticosterone appeared in liver and intestine within 5 min. The major steroid in liver at 5 min postinjection was found to be corticosterone, although acidic met
Purpose: Sentinel lymph node biopsy (SLNB) is an accurate andeffective means of axillary nodal staging in early breast cancer. However its indication after neoadjuvant chemotherapy (NAC) isunder constant debate. The present study evaluates the reliabilityof SLNB in assessing axillary nodal status after NAC. Methods:Data from 281 patients who had received NAC and subsequentSLNB were reviewed. The identification and false negative ratesof SLNB were determined and the clinicopathologic factors asso
Horseshoe kidney (HSK) is the most common congenital abnormality of the urologic system encountered during abdominal aortic aneurysm (AAA) surgery. Here, the authors report a case of AAA coexisting with HSK that was successfully treated by open surgery. Two accessory renal arteries of 2.5 mm and 3.1 mm were reimplanted. One of the implanted arteries later occluded and infarct of the isthmus developed, but there was no impairment of renal function. The authors discuss the complexity of the surgic
Traumatic dissection of the celiac artery without aortic dissection is a rare event. Here we describe two cases of celiac artery dissection after blunt abdominal trauma managed conservatively without surgical or endovascular intervention. Keywords: Celiac artery; Vascular system injuries; Abdominal injuries
Low anti-spike IgG levels after third vaccination in kidney transplant recipients were associated with symptomatic breakthrough infection and, particularly, with hospitalization during the Omicron surge. These data can be used to identify patients requiring additional protective measures, such as passive immunization using monoclonal antibodies.
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