이병훈 교수

Primary adenocarcinoma of the seminal vesicles is a rare neoplasm. Congenital seminal vesicle cysts are commonly associated with unilateral renal agenesis or dysgenesis. To the best of our knowledge, mucinous adenocarcinoma of the seminal vesicle cyst that's associated with an ectopic ureter opening into the seminal vesicle and ipsilateral renal agenesis has not been described in the radiological literature. We report here on the radiological findings of a primary adenocarcinoma of a seminal ves

Single particle tracking is a compelling technique for investigating the dynamics of nanoparticles and biological molecules in a broad range of research fields. In particular, recent advances in fluorescence microscopy have made single molecule tracking a prevalent method for studying biomolecules with a high spatial and temporal precision. Particle tracking algorithms have matured over the past three decades into more easily accessible platforms. However, there is an inherent difficulty in trac

Local protein synthesis mediates precise spatio-temporal regulation of gene expression for neuronal functions such as long-term plasticity, axon guidance and regeneration. To reveal the underlying mechanisms of local translation, it is crucial to understand mRNA transport, localization and translation in live neurons. Among various techniques for mRNA analysis, fluorescence microscopy has been widely used as the most direct method to study localization of mRNA. Live-cell imaging of single RNA mo

Memories are thought to be encoded in populations of neurons called memory trace or engram cells. However, little is known about the dynamics of these cells because of the difficulty in real-time monitoring of them over long periods of time in vivo. To overcome this limitation, we present a genetically encoded RNA indicator (GERI) mouse for intravital chronic imaging of endogenous <i>Arc</i> messenger RNA (mRNA)-a popular marker for memory trace cells. We used our GERI to identify <i>Arc</i>-pos

Localization of mRNA facilitates spatiotemporally controlled protein expression in neurons. In axons, mRNA transport followed by local protein synthesis plays a critical role in axonal growth and guidance. However, it is not yet clearly understood how mRNA is transported to axonal subcellular sites and what regulates axonal mRNA localization. Using a transgenic mouse model in which endogenous β-actin mRNA is fluorescently labeled, we investigated β-actin mRNA movement in axons of hippocampal neu

Minimally invasive plate osteosynthesis is the most commonly used minimally invasive surgery technique for tibial fractures, possibly involving single or dual plate methods. Herein, we performed a finite element analysis to investigate plate strength according to the plate type, length, and presence of a fibula by constructing a three-dimensional tibia model. A thickness of 20 mm was cut 50 mm distal from the lateral plateau, and the ligaments were created. Plates were modeled with lengths of 15

Dendrites integrate synaptic inputs to trigger action potentials, and dendrites carry back-propagating action potentials (bAPs) to synapses where these signals contribute to plasticity. Despite strong evidence for a rich repertoire of nonlinear dendritic excitations, the <i>in vivo</i> roles of these excitations in dendritic integration and back-propagation remain uncertain. Here, we used high-speed voltage imaging through a chronically implanted microprism to map membrane potential dynamics fro

The recombinant two-kringle domain of human tissue-type plasminogen activator (TK1-2) was found to inhibit angiogenesis and tumor growth. Recently, we found that TK1-2 inhibits adhesive differentiation of endothelial progenitor cells, and its contribution to tumor angiogenesis. In this study, we investigated the effects of TK1-2 on extracellular matrix-induced adhesion, signaling, and migration in order to understand the mechanism of action of TK1-2. When human umbilical vein endothelial cells w

삼차원 역전사(3D backprojection) 기법은 수백 장의 이차원 투영영상을 가지고 대상물의 공간적인 위치 파악이 가능한 단층 영상(tomography)을 생성하기 위해 사용되는 재구성 기법이다. 재구성 기법은 단층 영상을 구성하는 결과볼륨의 모든 화소로부터 각 화소 위치에 기여할 값을 이차원 투영영상에서 계산하여 얻어오기 때문에 결과볼륨이 커지거나 투영영상의 수가 증가하게 되면 전체 계산량은 상당히 증가하게 된다. 이러한 문제를 해결하기 위해 최근 범용 그래픽스 하드웨어(graphics processing unit: GPU) 기반의 고속 삼차원 재구성 기법이 연구되었으며 상당한 성능 향상을 가져왔다. 본 논문에서는 기존의 단일 GPU 기반의 삼차원 재구성 기법을 다중 GPU 기반으로 확장할 때 입력되는 투영영상 크기와 결과볼륨의 크기에 따라서 효율적으로 동작될 수 있는 두 가지 병렬 처리 구현 기법에 대해 제시하고 비교 분석한다. 제안한 병렬 처리 구현 기법은 투영영상을 입

Abstract Memories are thought to be encoded in populations of neurons called memory trace or engram cells. However, little is known about the dynamics of these cells because of the difficulty in real-time monitoring of them over long periods of time in vivo . To overcome this limitation, we present a genetically-encoded RNA indicator (GERI) mouse for intravital chronic imaging of endogenous Arc mRNA—a popular marker for memory trace cells. We used our GERI to identify Arc -positive neurons in re

Meningiomas are the most common benign extra-axial brain tumors. Central necrosis of meningiomas is rare, and may occur spontaneously or as a result of hypoperfusion. This report presents the case of a 61-year-old patient who suffered an acute aneurysmal subarachnoid hemorrhage and subsequent loss of consciousness. An additional large extra-axial brain tumor was incidentally discovered during work-up of the patient. Serial computed tomography images demonstrated rapid progression of central tumo