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이창현 교수

Chang Hyun Lee

서울대학교 · 의학

연구실 소개

이창현 교수의 연구실은 조직 공학과 재생의료 분야에서 활발한 연구를 수행하고 있습니다. 주요 연구 방향은 인체 복합 조직(예: 무릎 연골, 치주조직)의 기능적 재생을 위한 3차원 프린팅 생체재료와 생장인자 조절 방출 시스템 개발입니다. 특히 CTGF와 TGF-β3 같은 생물학적 신호를 정밀하게 조절하여 내재적 줄기세포의 분화를 유도함으로써 자연스러운 조직 재생을 이끌어내는 데 초점을 맞추고 있습니다. 또한, 센서 기반 분석 기술을 활용한 생물학적 분자 감지 기술 개발도 함께 진행하고 있습니다.

조직 공학3D 프린팅생장인자 조절줄기세포 분화생체재료

연구 현황

논문 수
294
총 인용 수
6,326
최근 5년 논문
48
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
48총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
310총합
20222023202420252026

주요 논문

15
1
리뷰|인용수 312·2008
Radiation Dose Modulation Techniques in the Multidetector CT Era: From Basics to Practice
Chang Hyun Lee, Jin Mo Goo, Hyun Ju Ye, Sung‐Joon Ye, Chang Min Park, Eun Ju Chun, Jung-Gi Im
SJR Q1FWCI 13.4Radiographics

Radiation exposure to the patient has become a concern for the radiologist in the multidetector computed tomography (CT) era. With the introduction of faster multidetector CT scanners, various techniques have been developed to reduce the radiation dose to the patient; one method is automatic exposure control (AEC). AEC systems make use of different types of control, including patient-size AEC, z-axis AEC, rotational or angular AEC, or a combination of two or more of these types. AEC systems oper

Radiology, Nuclear Medicine and ImagingMedicine
2
리뷰|인용수 174·2021
Impact of long-term exposure to ambient air pollution on the incidence of chronic obstructive pulmonary disease: A systematic review and meta-analysis
Jimyung Park, Hyung‐Jun Kim, Chang‐Hoon Lee, Chang Hyun Lee, Hyun Woo Lee, Chang Hyun Lee, Hyun Woo Lee
SJR Q1FWCI 11.8Environmental ResearchOA

Long-term exposure to PM<sub>2.5</sub> and NO<sub>2</sub> can be associated with increased incidence of COPD.

Health, Toxicology and MutagenesisEnvironmental Science
3
논문|인용수 112·2018
A Regulatory Response to Ribosomal Protein Mutations Controls Translation, Growth, and Cell Competition
Chang Hyun Lee, Marianthi Kiparaki, Jorge Polo Blanco, Virginia Folgado, Zhejun Ji, Amit Kumar, Gerard Rimesso, Nicholas E. Baker
SJR Q1FWCI 4.6Developmental CellOA
Molecular BiologyBiochemistry, Genetics and Molecular Biology
4
논문|인용수 86·2004
A novel SONOS structure of SiO/sub 2//SiN/Al/sub 2/O/sub 3/ with TaN metal gate for multi-giga bit flash memories
Chang Hyun Lee, Kyung In Choi, Myoung Kwan Cho, Yun‐Heub Song, Kyu Charn Park, Kinam Kim
FWCI 6.4

A novel SONOS structure of SiO/sub 2//SiN/Al/sub 2/O/sub 3/ (SANOS) with TaN metal gate is for the first time proposed for the next generation non-volatile memory technology. When TaN metal gate is applied for the SANOS instead of commonly used n+ poly-Si, the unwanted backward Fowler-Nordheim tunneling current of electrons through the top oxide is significantly suppressed owing to its higher work function and better compatibility with high k dielectrics. As a result, the program/erase speed is

Electrical and Electronic EngineeringEngineering
5
논문|인용수 80·2008
Radiologic and Pathologic Findings of Nonpalpable Thyroid Carcinomas Detected by Ultrasonography in a Medical Screening Center
Ji Yang Kim, Chang Hyun Lee, Soo Young Kim, Woo Ki Jeon, Jin Hwa Kang, Su Kyung An, Woo Sun Jun
SJR Q2FWCI 3.8Journal of Ultrasound in Medicine

Ultrasonographic findings suggesting malignancy should be preferentially considered as indicators for FNA, regardless of size, in nonpalpable thyroid nodules. However, extracapsular invasion and lymph node metastasis are closely related to the size of the thyroid nodule.

Endocrinology, Diabetes and MetabolismMedicine
6
논문|인용수 43·2009
Efficacy of Computer-Aided Detection System and Thin-Slab Maximum Intensity Projection Technique in the Detection of Pulmonary Nodules in Patients With Resected Metastases
Eun‐Ah Park, Jin Mo Goo, Jeong Won Lee, Chang Hyun Kang, Hyun Ju Lee, Chang Hyun Lee, Chang Min Park, Ho Yun Lee, Jung-Gi Im
SJR Q1FWCI 2.6Investigative Radiology

In candidates for metastatectomy, reading with the aid of either CAD or MIP significantly improved the detection of malignant nodules compared with using thin-section CT alone.

Pulmonary and Respiratory MedicineMedicine
7
논문|인용수 42·2007
The Crazy-paving Sign<sup>1</sup>
Chang Hyun Lee
SJR Q1FWCI 2.2Radiology
Pulmonary and Respiratory MedicineMedicine
8
논문|인용수 40·2007
CTA Contrast Enhancement of the Aorta and Pulmonary Artery
Chang Hyun Lee, Jin Mo Goo, Kyongtae T. Bae, Hyun Ju Lee, Kwang Gi Kim, Eun Ju Chun, Chang Min Park, Jung-Gi Im
SJR Q1FWCI 4.1Investigative Radiology

Saline chase prolongs the duration of plateau and delays peak enhancement of the pulmonary artery and aorta. Saline chase injected at half the rate of contrast medium injection allowed more uniform and prolonged plateau contrast enhancement than other protocols.

Radiology, Nuclear Medicine and ImagingMedicine
9
논문|인용수 40·2007
Determination of Optimal Timing Window for Pulmonary Artery MDCT Angiography
Chang Hyun Lee, Jin Mo Goo, Hyun Ju Lee, Kwang Gi Kim, Jung-Gi Im, Kyongtae T. Bae
SJR Q1FWCI 2.7American Journal of Roentgenology

With our study protocol of a 30-second injection and 10-second saline flush, the optimal temporal window to achieve pulmonary artery enhancement greater than 200 H was from 16 seconds to 41 seconds after the start of the injection.

Internal MedicineMedicine
10
논문|인용수 36·2016
Whole-Genome Sequencing and iPLEX MassARRAY Genotyping Map an EMS-Induced Mutation Affecting Cell Competition in <i>Drosophila melanogaster</i>
Chang Hyun Lee, Gerard Rimesso, David M. Reynolds, Jinlu Cai, Nicholas E. Baker
SJR Q2FWCI 1.2G3 Genes Genomes GeneticsOA

Cell competition, the conditional loss of viable genotypes only when surrounded by other cells, is a phenomenon observed in certain genetic mosaic conditions. We conducted a chemical mutagenesis and screen to recover new mutations that affect cell competition between wild-type and RpS3 heterozygous cells. Mutations were identified by whole-genome sequencing, making use of software tools that greatly facilitate the distinction between newly induced mutations and other sources of apparent sequence

Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
논문|인용수 31·2008
Semiquantitative Measurement of Murine Bleomycin-Induced Lung Fibrosis in In Vivo and Postmortem Conditions Using Microcomputed Tomography: Correlation With Pathologic Scores???Initial Results
Hyun Ju Lee, Jin Mo Goo, Na Ra Kim, Sunghoon Kim, Doo Hyun Chung, Kyu-Ri Son, Hyo‐Cheol Kim, Chang Hyun Lee, Chang Min Park, Eun Ju Chun, Jung-Gi Im
SJR Q1FWCI 2.8Investigative Radiology

Micro-CT scores and pathologic scores were found to be well correlated by in vivo and postmortem micro-CT. Although agreements between in vivo and postmortem micro-CT were significant, the confidence levels for fibrosis-related CT findings were significantly higher by postmortem micro-CT.

Pulmonary and Respiratory MedicineMedicine
12
논문|인용수 27·2008
Highly scalable NAND flash memory with robust immunity to program disturbance using symmetric inversion-type source and drain structure
Chang Hyun Lee, Jungdal Choi, Young‐Woo Park, Changseok Kang, Byeong-In Choi, Hyunjae Kim, Hyunsil Oh, Won-Seong Lee
FWCI 5.0

The symmetric inversion-type S/D structure has been employed for achieving available program disturbance for scaled NAND flash memory beyond sub-40 nm node. The inversion S/D structure enables the channel doping to be reduced due to non-existence of n-lateral diffusion and it suppresses charge sharing between program-inhibit channels, resulting in superior program disturbance. Moreover, the cells show better current drivability in the technology node less than 50 nm by more successful working of

Computer Networks and CommunicationsComputer Science
13
논문|인용수 24·2008
Is the Computer-Aided Detection Scheme for Lung Nodule Also Useful in Detecting Lung Cancer?
Jin Mo Goo, Hyae Young Kim, Jeong Won Lee, Hyun Ju Lee, Chang Hyun Lee, Kyung Won Lee, Tae Jung Kim, Kun Young Lim, Seong Ho Park, Kyongtae T. Bae
SJR Q3FWCI 1.0Journal of Computer Assisted Tomography

The overall radiologists' performance of detecting lung nodules was improved significantly with the use of CAD, whereas no statistical significance was observed for the detection of lung cancers. The use of CAD, however, contributed to the detection of additional lung cancers for less experienced readers.

Pulmonary and Respiratory MedicineMedicine
14
논문|인용수 21·2012
Quantitative analysis of dynamic airway changes after methacholine and salbutamol inhalation on xenon-enhanced chest CT
Sang Joon Park, Chang Hyun Lee, Jin Mo Goo, Jong Hyo Kim, Eun‐Ah Park, Jae‐Woo Jung, Heung‐Woo Park, Sang‐Heon Cho
SJR Q1FWCI 1.9European Radiology
Atomic and Molecular Physics, and OpticsPhysics and Astronomy
15
논문|인용수 18·2015
Effects of Attitude, Social Influence, and Self-Efficacy Model Factors on Regular Mammography Performance in Life-Transition Aged Women in Korea
Chang Hyun Lee, Young Im Kim
SJR Q2FWCI 0.6Asian Pacific Journal of Cancer PreventionOA

Promotional strategies that could improve self-efficacy, reinforce social influence and reduce geographical, time and financial barriers are needed to increase the regular mammography performance rate in life-transition aged.

OncologyMedicine

대표 연구 분야

Pulmonary and Respiratory MedicineRadiology, Nuclear Medicine and ImagingOncologyPhysiologyEpidemiologyBiomedical Engineering

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