이창현 교수
Chang Hyun Lee
서울대학교 · 의학
연구실 소개
이창현 교수의 연구실은 조직 공학과 재생의료 분야에서 활발한 연구를 수행하고 있습니다. 주요 연구 방향은 인체 복합 조직(예: 무릎 연골, 치주조직)의 기능적 재생을 위한 3차원 프린팅 생체재료와 생장인자 조절 방출 시스템 개발입니다. 특히 CTGF와 TGF-β3 같은 생물학적 신호를 정밀하게 조절하여 내재적 줄기세포의 분화를 유도함으로써 자연스러운 조직 재생을 이끌어내는 데 초점을 맞추고 있습니다. 또한, 센서 기반 분석 기술을 활용한 생물학적 분자 감지 기술 개발도 함께 진행하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Radiation exposure to the patient has become a concern for the radiologist in the multidetector computed tomography (CT) era. With the introduction of faster multidetector CT scanners, various techniques have been developed to reduce the radiation dose to the patient; one method is automatic exposure control (AEC). AEC systems make use of different types of control, including patient-size AEC, z-axis AEC, rotational or angular AEC, or a combination of two or more of these types. AEC systems oper
Long-term exposure to PM<sub>2.5</sub> and NO<sub>2</sub> can be associated with increased incidence of COPD.
A novel SONOS structure of SiO/sub 2//SiN/Al/sub 2/O/sub 3/ (SANOS) with TaN metal gate is for the first time proposed for the next generation non-volatile memory technology. When TaN metal gate is applied for the SANOS instead of commonly used n+ poly-Si, the unwanted backward Fowler-Nordheim tunneling current of electrons through the top oxide is significantly suppressed owing to its higher work function and better compatibility with high k dielectrics. As a result, the program/erase speed is
Ultrasonographic findings suggesting malignancy should be preferentially considered as indicators for FNA, regardless of size, in nonpalpable thyroid nodules. However, extracapsular invasion and lymph node metastasis are closely related to the size of the thyroid nodule.
In candidates for metastatectomy, reading with the aid of either CAD or MIP significantly improved the detection of malignant nodules compared with using thin-section CT alone.
Saline chase prolongs the duration of plateau and delays peak enhancement of the pulmonary artery and aorta. Saline chase injected at half the rate of contrast medium injection allowed more uniform and prolonged plateau contrast enhancement than other protocols.
With our study protocol of a 30-second injection and 10-second saline flush, the optimal temporal window to achieve pulmonary artery enhancement greater than 200 H was from 16 seconds to 41 seconds after the start of the injection.
Cell competition, the conditional loss of viable genotypes only when surrounded by other cells, is a phenomenon observed in certain genetic mosaic conditions. We conducted a chemical mutagenesis and screen to recover new mutations that affect cell competition between wild-type and RpS3 heterozygous cells. Mutations were identified by whole-genome sequencing, making use of software tools that greatly facilitate the distinction between newly induced mutations and other sources of apparent sequence
Micro-CT scores and pathologic scores were found to be well correlated by in vivo and postmortem micro-CT. Although agreements between in vivo and postmortem micro-CT were significant, the confidence levels for fibrosis-related CT findings were significantly higher by postmortem micro-CT.
The symmetric inversion-type S/D structure has been employed for achieving available program disturbance for scaled NAND flash memory beyond sub-40 nm node. The inversion S/D structure enables the channel doping to be reduced due to non-existence of n-lateral diffusion and it suppresses charge sharing between program-inhibit channels, resulting in superior program disturbance. Moreover, the cells show better current drivability in the technology node less than 50 nm by more successful working of
The overall radiologists' performance of detecting lung nodules was improved significantly with the use of CAD, whereas no statistical significance was observed for the detection of lung cancers. The use of CAD, however, contributed to the detection of additional lung cancers for less experienced readers.
Promotional strategies that could improve self-efficacy, reinforce social influence and reduce geographical, time and financial barriers are needed to increase the regular mammography performance rate in life-transition aged.
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