김주현 교수

Layer 6 corticothalamic neurons are thought to modulate incoming sensory information via their intracortical axons targeting the major thalamorecipient layer of the neocortex, layer 4, and via their long-range feedback projections to primary sensory thalamic nuclei. However, anatomical reconstructions of individual layer 6 corticothalamic (L6 CT) neurons include examples with axonal processes ramifying within layer 5, and the relative input of the overall population of L6 CT neurons to layers 4

Neuroligin-1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. Despite evidence for the role of neuroligin-1 in specifying excitatory synapses, the underlying molecular mechanisms and physiological consequences that neuroligin-1 may have at mature synapses of normal adult animals remain unknown. By silencing endogenous neuroligin-1 acutely in the amygdala

The claustrum, a poorly understood subcortical structure located between the cortex and the striatum, forms widespread connections with almost all cortical areas, but the cellular organization of claustral circuits remains largely unknown. Based primarily on anatomical data, it has been proposed that the claustrum integrates activity across sensory modalities. However, the extent to which the synaptic organization of claustral circuits supports this integration is unclear. Here, we used paired w

Sepsis is a devastating condition characterized by a systemic inflammatory response. Recently, high mobility group box 1 (HMGB1) was identified as a necessary and sufficient mediator of the lethal systemic inflammation caused by sepsis. However, despite its clinical importance, the mechanism of HMGB1 release has remained to be elusive. In this study, we demonstrate that the IFN-beta-mediated JAK/STAT pathway is essential for LPS or Escherichia coli-induced HMGB1 release, which is dependent on To

한국 노인에 대한 사회적 이해를 위해서 기존의 노년을 바라보는 윤리적이고 당위적 가치의 한계를 인정하고 현재 한국 사회의 노인을 이해하기 위해 연령주의라는 분석틀을 주목해본다. 지금까지 한국에서는 연령주의가 노인의 사회적 상황을 설명하고 현상을 파악하기 위한 분석틀로서 기초 논의가 부족하였다. 연령주의가 등장하게 된 사회구조적 맥락에 대한 차분한 검토를 통해서 한국적 상황에의 적용을 타진해 볼 수 있을 것이다. 본 연구에서는 노인에 대한 사회적 이해를 위해 서구에서 시작된 연령주의 논의의 전개와 그 배경으로써 근대화, 복지국가와 은퇴, 그리고 생애단계의 변화, 연령주의와 노년기의 관계를 고찰해본다. 더불어 노인의 생활세계의 주요한 제측면을 연령주의 관점에서 살펴본다. 서구에서 비롯된 노년의 사회적 이해 방식인 연령주의는 노인에 대한 편견과 부정적 관념들이 노인에 대한 차별과 억압으로 이어져서 구조적 관계로 굳어졌다는 주장에 이르렀다. 근대화에 따른 노인의 사회적 지위 변화, 복지국

Cell type-specific changes in neuronal excitability have been proposed to contribute to the selective degeneration of corticospinal neurons in amyotrophic lateral sclerosis (ALS) and to neocortical hyperexcitability, a prominent feature of both inherited and sporadic variants of the disease, but the mechanisms underlying selective loss of specific cell types in ALS are not known. We analyzed the physiological properties of distinct classes of cortical neurons in the motor cortex of <i>hSOD1<sup>

A novel microelectrode modification method is reported for neural electrode engineering with a flake nanostructure (nanoflake). The nanoflake-modified electrodes are fabricated by combining conventional lithography and electrochemical deposition to implement a microelectrode array (MEA) on a glass substrate. The unique geometrical properties of nanoflake sharp tips and valleys are studied by optical, electrochemical and electrical methods in order to verify the advantages of using nanoflakes for

Pseudomonas putida KT2440 is a metabolically versatile soil bacterium useful both as a model biodegradative organism and as a host of catalytic activities of biotechnological interest. In this report, we present the high-resolution transcriptome of P. putida cultured on different carbon sources as revealed by deep sequencing of the corresponding RNA pools. Examination of the data from growth on substrates that are processed through distinct pathways (glucose, fructose, succinate and glycerol) re

Hypothalamic tanycytes, radial glial cells that share many features with neuronal progenitors, can generate small numbers of neurons in the postnatal hypothalamus, but the identity of these neurons and the molecular mechanisms that control tanycyte-derived neurogenesis are unknown. In this study, we show that tanycyte-specific disruption of the NFI family of transcription factors (<i>Nfia/b/x</i>) robustly stimulates tanycyte proliferation and tanycyte-derived neurogenesis. Single-cell RNA seque

Fluidic resonators with integrated microchannels (hollow resonators) are attractive for mass, density, and volume measurements of single micro/nanoparticles and cells, yet their widespread use is limited by the complexity of their fabrication. Here we report a simple and cost-effective approach for fabricating hollow microtube resonators. A prestructured silicon wafer is annealed at high temperature under a controlled atmosphere to form self-assembled buried cavities. The interiors of these cavi

We report a large converse magnetoelectric (CME) effect at room temperature in a multiferroic heterostructure formed from thin layers of perpendicularly magnetized CoxPd1-x alloys deposited on a piezoelectric single-crystal of lead magnesium niobate-lead titanate PMN-PT(001). The CME results from a strain-induced reorientation of the CoPd magnetization. By varying the composition and thickness of the CoxPd1-x film, a large converse magnetoelectric coupling constant, α=8×10−7 s/m, at room tempera

Regenerating lost or damaged tissue is the primary goal of Tissue Engineering. 3D bioprinting technologies have been widely applied in many research areas of tissue regeneration and disease modeling with unprecedented spatial resolution and tissue-like complexity. However, the extraction of tissue architecture and the generation of high-resolution blueprints are challenging tasks for tissue regeneration. Traditionally, such spatial information is obtained from a collection of microscopic images