손철호 교수
Chulho Sohn
서울대학교 · 의학
연구실 소개
손철호 교수의 연구실은 뇌혈관 질환의 조기 진단과 병변 기전 해석을 목표로 하며, 고해상도 MRI를 활용한 뇌부종, 출혈, 뇌경색 등 뇌혈관 손상의 영상학적 특징을 규명하고 있습니다. 특히 3T MRI를 기반으로 한 ASL, SWI, GRE T2*-weighted, FLAIR 등 다양한 영상 시퀀스를 응용하여 뇌졸중의 기전 분석과 뇌사 진단에 기여하고 있으며, 동맥기계적 thrombectomy(EVT)와 연계된 영상 예측 지표 개발에도 주력하고 있습니다. 연구는 임상적 적용에 초점을 맞추어 진단 정확도 향상과 환자 예후 예측에 기여하고자 합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Cavernous hemangiomas occur very rarely in the cavernous sinus and are difficult to diagnose preoperatively. MR images obtained in five patients with surgically verified cavernous hemangiomas in the cavernous sinus were reviewed. MR images showed hypointensity on T1-weighted images and well-defined hyperintensity on T2-weighted images with marked homogeneous enhancement after contrast material administration. We report the characteristic MR imaging observations for these lesions.
We describe MR imaging findings applying gradient echo (GRE) T2*-weighted and fluid-attenuated inversion recovery (FLAIR) MR images at 3T to three patients with hyperacute subarachnoid and intraventricular hemorrhage from ruptured aneurysms. Hyperacute subarachnoid and intraventricular hemorrhages (SAH and IVH) were more clearly visualized as an area of decreased signal intensity on GRE T2*-weighted sequences than on FLAIR sequences in all three patients. These preliminary results suggest that a
T2-weighted imaging, DWI, and MRA using 3T MRI may be useful for diagnosing brain death. However, SWI findings are not specific due to high false positive findings.
Stroke mechanism has a major influence on outcomes, and outcome predictors differ according to the underlying mechanism in acute BA occlusion with EVT. Clot sign profile on pre-angiography MRI might be useful to determine the underlying mechanism.
Our results demonstrate that the correlation between the CBF values from the ASL and DSC tends to be weaker when the transit time is more delayed, with the restoration of the strength of the correlation when the TTP is extremely delayed (>25 seconds). Understanding the effect of delayed transit time on the CBF from ASL perfusion MR in a clinical setting would facilitate the proper interpretation of ASL images.
ASL imaging could detect CCD in 75% of patients with hyperacute infarction. We found that CCD was more prevalent in patients with arterial occlusion, larger ischemic brain volumes, and higher initial NIHSS and mRS scores. In particular, vessel occlusion and initial mRS score appeared to be significantly related with CCD pathophysiology in the hyperacute stage.
Serial administrations of gadobutrol did not result in signal increases in the DN or GP on unenhanced T1-weighted MR images due to gadolinium retention.
Neither carotid nor intracranial artery stenosis appears to be associated with brain Aβ burden, while intracranial artery stenosis is related to amyloid-independent neurodegeneration, particularly hippocampal atrophy.
Mean transit time is the most predictive parameter for assessing decreased CVR in patients with unilateral steno-occlusive vascular disease.
Relative hippocampal volume measures provided by automated brain segmentation software can be useful for screening cerebral Aβ positivity in clinical practice for patients with amnestic MCI. The information may also help clinicians interpret structural MRI to predict outcomes and determine early intervention for delaying the progression to Alzheimer's disease dementia.
Intravenous iron treatment results in changes in brain iron content which correlate to reductions in RLS severity. This suggests a connection between symptom improvement and the associated specific brain regions constituting the sensorimotor network.
Herein, we report on an unusual case of craniopharyngioma arising in the temporal lobe with no prior history of surgery and with no connection to the craniopharyngeal duct. MR images showed a cystic tumor with a small solid portion. To the best of our knowledge, this is the first case of a craniopharyngioma occurring in the temporal lobe.
The preoperative examinations by doppler-sonography of 83 patients with tumors of the breast are presented. The examinations are done with newest technique: duplex-sonography in slow-flow-technique (AI 3200, Dornier); colour-sonography in MEM-technique (AI 5200, Dornier) and synchronical colour-doppler++ (Quantum 2000, Siemens) and CW-doppler-sonography (Vasocope 3, Kranzbühler). There is a markable difference between the side of carcinoma and the normal side as well as pre- and postmenopausal p
대표 연구 분야
손철호 교수의 연구를 Nubint에서 더 깊이 살펴보세요
이 연구실의 논문을 앱에서 열어 AI와 함께 읽고, 핵심을 요약하고, 내 글에 인용하세요.