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구대림 교수

Dae Lim Koo

서울대학교 · 의학

연구실 소개

구대림 교수의 연구실은 수면 장애와 뇌-심혈관계의 상호작용을 중심으로, 수면의 생리학적 기전과 임상적 영향을 다룹니다. 특히 수면 무호흡증(OSA) 환자에서 뇌 구조와 기능의 변화를 체계적으로 분석하며, 비침습적 센서 기반 수면 진단 기술(예: 레이더 기반 다중 모달리티 수면 측정)의 개발에도 주력하고 있습니다. 또한 청소년의 수면 패턴과 정서적 건강 간의 연관성, 항경련제 치료가 인지 기능에 미치는 영향 등 다양한 수면-건강 간 상관관계를 탐구하고 있습니다.

수면 장애수면 무호흡증뇌-심혈관계 상호작용비침습적 수면 진단인지 기능

연구 현황

논문 수
94
총 인용 수
1,952
최근 5년 논문
29
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
29총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
112총합
20212022202320242025

주요 논문

15
1
리뷰|인용수 149·2018
Sleep Disturbances as a Risk Factor for Stroke
Dae Lim Koo, Hyunwoo Nam, Robert J. Thomas, Chang‐Ho Yun
SJR Q1FWCI 8.5Journal of StrokeOA

Sleep, a vital process of human being, is carefully orchestrated by the brain and consists of cyclic transitions between rapid eye movement (REM) and non-REM (NREM) sleep. Autonomic tranquility during NREM sleep is characterized by vagal dominance and stable breathing, providing an opportunity for the cardiovascular-neural axis to restore homeostasis, in response to use, distress or fatigue inflicted during wakefulness. Abrupt irregular swings in sympathovagal balance during REM sleep act as pha

PhysiologyMedicine
2
논문|인용수 71·2017
Changes in subcortical shape and cognitive function in patients with chronic insomnia
Dae Lim Koo, Jeong-Hyeon Shin, Jae‐Sung Lim, Joon‐Kyung Seong, Eun Yeon Joo
SJR Q1FWCI 7.0Sleep Medicine
Experimental and Cognitive PsychologyPsychology
3
논문|인용수 71·2020
Association between morningness‐eveningness, sleep duration, weekend catch‐up sleep and depression among Korean high‐school students
Dae Lim Koo, Kwang Ik Yang, Jee Hyun Kim, Daeyoung Kim, Jun‐Sang Sunwoo, Young Hwangbo, Hwa Reung Lee, Seung Bong Hong
SJR Q1FWCI 6.9Journal of Sleep ResearchOA

The present study aimed to examine the association between morningness-eveningness preferences, sleep duration, weekend catch-up sleep duration and depression among Korean high-school students. A total of 8,655 high-school students participated from 15 districts in South Korea and completed an online self-report questionnaire. The following sleep characteristics were assessed: weekday and weekend sleep duration, weekend catch-up sleep duration, morningness-eveningness preference, perceived suffi

Experimental and Cognitive PsychologyPsychology
4
논문|인용수 66·2012
Effects of levetiracetam as a monotherapy on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy
Dae Lim Koo, Eun Yeon Joo, Daeyoung Kim, Seung Bong Hong
SJR Q2FWCI 9.4Epilepsy Research
Pediatrics, Perinatology and Child HealthMedicine
5
논문|인용수 40·2019
White matter tract-specific alterations in male patients with untreated obstructive sleep apnea are associated with worse cognitive function
Dae Lim Koo, Hye Ryun Kim, Hosung Kim, Joon‐Kyung Seong, Eun Yeon Joo
SJR Q1FWCI 2.1SLEEPOA

The TSSA method indeed identified previously unrevealed tract-specific disruptions in OSA. Furthermore, reduced FA values in the frontal lobe portion of the right UNC which has been known to be involved in working memory function were significantly associated with lower cognitive performance in patients with untreated OSA.

PhysiologyMedicine
6
논문|인용수 34·2022
Automated Detection of Sleep Apnea-Hypopnea Events Based on 60 GHz Frequency-Modulated Continuous-Wave Radar Using Convolutional Recurrent Neural Networks: A Preliminary Report of a Prospective Cohort Study
Jae Won Choi, Dong Hyun Kim, Dae Lim Koo, Yangmi Park, Hyunwoo Nam, Ji-Hyun Lee, Hyo Jin Kim, Seung‐No Hong, Gwangsoo Jang, Sungmook Lim, Baekhyun Kim
SJR Q1FWCI 4.0SensorsOA

Radar is a promising non-contact sensor for overnight polysomnography (PSG), the gold standard for diagnosing obstructive sleep apnea (OSA). This preliminary study aimed to demonstrate the feasibility of the automated detection of apnea-hypopnea events for OSA diagnosis based on 60 GHz frequency-modulated continuous-wave radar using convolutional recurrent neural networks. The dataset comprised 44 participants from an ongoing OSA cohort, recruited from July 2021 to April 2022, who underwent over

PhysiologyMedicine
7
논문|인용수 30·2013
Effect of oxcarbazepine on bone mineral density and biochemical markers of bone metabolism in patients with epilepsy
Dae Lim Koo, Kyoung Jin Hwang, Suk Won Han, Ji Young Kim, Eun Yeon Joo, Won-Chul Shin, Hyang Woon Lee, Dae‐Won Seo, Seung Bong Hong
SJR Q2FWCI 3.4Epilepsy Research
Pediatrics, Perinatology and Child HealthMedicine
8
논문|인용수 29·2017
Cerebral Microbleeds on MRI in Patients with Obstructive Sleep Apnea
Dae Lim Koo, Jun Yup Kim, Jae‐Sung Lim, Hyung‐Min Kwon, Hyunwoo Nam
SJR Q1FWCI 2.6Journal of Clinical Sleep MedicineOA
PhysiologyMedicine
9
논문|인용수 22·2013
Effects of Levetiracetam Monotherapy on the Cognitive Function of Epilepsy Patients
Dae Lim Koo, Kyoung Jin Hwang, Daeyoung Kim, You‐Jin Kim, Ji Young Kim, Won‐Chul Shin, Mi Rim Kim, Eun Yeon Joo, Jong‐Min Lee, Seung Bong Hong
SJR Q3FWCI 1.7European Neurology

Our study suggested that LEV monotherapy had no harmful effect on cognitive function in drug-naïve patients with epilepsy.

Psychiatry and Mental healthMedicine
10
논문|인용수 20·2013
The Physiology of Normal Sleep
Dae Lim Koo, Juhan Kim
FWCI 0.3Hanyang Medical ReviewsOA

.

Cognitive NeuroscienceNeuroscience
11
논문|인용수 19·2016
Acoustic Characteristics of Stridor in Multiple System Atrophy
Dae Lim Koo, Jee‐Young Lee, Eun Yeon Joo, Seung Bong Hong, Hyunwoo Nam
SJR Q1FWCI 1.1PLoS ONEOA

Nocturnal stridor is a breathing disorder prevalent in patients with multiple system atrophy (MSA). An improved understanding of this breathing disorder is essential since nocturnal stridor carries a poor prognosis (an increased risk of sudden death). In this study, we aimed to classify types of stridor by sound analysis and to reveal their clinical significance. Patients who met the criteria for probable MSA and had undergone polysomnography (PSG) were recruited. Patients were then assessed cli

NeurologyMedicine
12
논문|인용수 18·2012
Acoustic characteristic of catathrenia and snoring: Different subtypes of catathrenia
Dae Lim Koo, Seung Bong Hong, Eun Yeon Joo
SJR Q1FWCI 0.3Sleep Medicine
PhysiologyMedicine
13
논문|인용수 16·2022
Sleep quality of patients with papillary thyroid carcinoma: a prospective longitudinal study with 5-year follow-up
Dae Lim Koo, Yangmi Park, Hyunwoo Nam, Young Jun Chai
SJR Q1FWCI 2.7Scientific ReportsOA

Abstract We evaluated the pre- and postoperative sleep quality of patients with newly diagnosed papillary thyroid carcinoma (PTC) who underwent thyroid surgery, and investigated the factors associated with persistent poor sleep quality. The Pittsburgh sleep quality index (PSQI), Epworth sleepiness scale, and Stanford sleepiness scale were used to estimate sleep quality and daytime sleepiness. Face-to-face surveys were conducted preoperatively, and 1, 4, and 10 months after thyroid surgery. The P

Experimental and Cognitive PsychologyPsychology
14
논문|인용수 14·2020
Moderate to severe obstructive sleep apnea during REM sleep as a predictor of metabolic syndrome in a Korean population
Dae Lim Koo, Hang-Rai Kim, Hyunwoo Nam
SJR Q1FWCI 1.1Sleep And Breathing
PhysiologyMedicine
15
논문|인용수 13·2023
More extensive white matter disruptions present in untreated obstructive sleep apnea than we thought: A large sample diffusion imaging study
Dae Lim Koo, Ryan P. Cabeen, Soon Hyun Yook, Steven Cen, Eun Yeon Joo, Hosung Kim
SJR Q1FWCI 2.3Human Brain MappingOA

Obstructive sleep apnea (OSA) may lead to white mater (WM) disruptions and cognitive deficits. However, no studies have investigated the full extent of the brain WM, and its associations with cognitive deficits in OSA remain unclear. We thus applied diffusion tensor imaging (DTI) tractography with multi-fiber models and used atlas-based bundle-specific approach to investigate the WM abnormalities for various tracts of the cerebral cortex, thalamus, brainstem, and cerebellum in patients with untr

PhysiologyMedicine

대표 연구 분야

PhysiologyExperimental and Cognitive PsychologyCognitive NeuroscienceNeurologyPsychiatry and Mental healthEpidemiology

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