김동현 교수
Dong Hyun Kim
서울대학교 · 의학
연구실 소개
김동현 교수의 연구실은 신경퇴행성질환, 특히 알츠하이머병의 병태생리와 치료 전략에 초점을 맞추고 있습니다. 유비코어 혈액 유래 간엽줄기세포(hUCB-MSCs)의 신경생성 유도 및 아밀로이드-β 플라크 감소 기전을 규명하며, 체내 내재된 신경세포 재생을 유도하는 비침습적 치료 전략을 개발하고 있습니다. 또한, 천연물 유래 화합물(예: 캐시아 옥타시플로라 추출물)이 인지 기능 저하를 완화하는 메커니즘을 밝혀내며 천연물 기반 뇌신경 보호제 개발에도 기여하고 있습니다. 이와 더불어 장내 미생물과 숙주 간의 상호작용이 만성 염증성 질환에 미치는 영향에 대한 연구도 병행하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Flavonoids, a group of naturally occurring antioxidants and metal chelators, can be used as tyrosinase inhibitors due to their formation of copper-flavonoid complexes. Thus, to investigate the underlying inhibition mechanism, a large group of flavonoids from several major flavones and flavonols were tested using fluorescence quenching spectroscopy. In addition, large differences in the tyrosinase inhibitory activities and chelating capacities according to the location of the hydroxyl group(s) in
Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bact
The Fourth Industrial Revolution incorporates the digital revolution into the physical world, creating a new direction in a number of fields, including artificial intelligence, quantum computing, nanotechnology, biotechnology, robotics, 3D printing, autonomous vehicles, and the Internet of Things. The artificial intelligence field has encountered a turning point mainly due to advancements in machine learning, which allows machines to learn, improve, and perform a specific task through data witho
Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bact
An electroless Ni‐Co‐P plating solution was developed for preparing soft magnetic thin films. In this plating process, the optimum bath composition and operating condition were obtained by investigating the effect of operating conditions on deposition rate, film composition, and magnetic properties. Soft magnetic films with low coercive force (lower than ) and high squareness (higher than 0.8) were prepared from these electroless Ni‐Co‐P plating processes. The alloy film deposited from the optim
PG102 may have potential as a safe and effective reagent for the prevention or treatment of asthma.
Vertebral compression fracture is a deformity of vertebral bodies found on lateral spine images. To diagnose vertebral compression fracture, accurate measurement of vertebral compression ratio is required. Therefore, rapid and accurate segmentation of vertebra is important for measuring the vertebral compression ratio. In this study, we used 339 data of lateral thoracic and lumbar vertebra images for training and testing a deep learning model for segmentation. The result of segmentation by the m
The incidence of VZV infection after PBSCT was high at 36.8%, with patients transplanted for LPDs at higher risk. The long-term use of low-dose acyclovir may be protective for VZV infection, although it does not completely prevent rebound of late VZV infection.
Torsional phacoemulsification showed superior efficiency for moderate cataracts, as compared with longitudinal phacoemulsification, in the early postoperative stage.
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