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김동현 교수

Dong Hyun Kim

서울대학교 · 의학

연구실 소개

김동현 교수의 연구실은 신경퇴행성질환, 특히 알츠하이머병의 병태생리와 치료 전략에 초점을 맞추고 있습니다. 유비코어 혈액 유래 간엽줄기세포(hUCB-MSCs)의 신경생성 유도 및 아밀로이드-β 플라크 감소 기전을 규명하며, 체내 내재된 신경세포 재생을 유도하는 비침습적 치료 전략을 개발하고 있습니다. 또한, 천연물 유래 화합물(예: 캐시아 옥타시플로라 추출물)이 인지 기능 저하를 완화하는 메커니즘을 밝혀내며 천연물 기반 뇌신경 보호제 개발에도 기여하고 있습니다. 이와 더불어 장내 미생물과 숙주 간의 상호작용이 만성 염증성 질환에 미치는 영향에 대한 연구도 병행하고 있습니다.

알츠하이머병간엽줄기세포인지 기능천연물장내 미생물

연구 현황

논문 수
435
총 인용 수
7,769
최근 5년 논문
119
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
119총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
1,078총합
20212022202320242025

주요 논문

15
1
논문|인용수 211·2006
Flavonoids as Mushroom Tyrosinase Inhibitors:  A Fluorescence Quenching Study
Dong-Hyun Kim, Jiyeoun Park, Jin‐Hee Kim, Cheolkyu Han, Jeong-Hyeok Yoon, Namdoo Kim, Jin‐Ho Seo, Choong‐Hwan Lee
SJR Q1FWCI 2.2Journal of Agricultural and Food Chemistry

Flavonoids, a group of naturally occurring antioxidants and metal chelators, can be used as tyrosinase inhibitors due to their formation of copper-flavonoid complexes. Thus, to investigate the underlying inhibition mechanism, a large group of flavonoids from several major flavones and flavonols were tested using fluorescence quenching spectroscopy. In addition, large differences in the tyrosinase inhibitory activities and chelating capacities according to the location of the hydroxyl group(s) in

Cell BiologyBiochemistry, Genetics and Molecular Biology
2
리뷰|인용수 178·2017
The interplay between host immune cells and gut microbiota in chronic inflammatory diseases
Dong-Hyun Kim, Melody Y. Zeng, Gabriel Núñez
SJR Q1FWCI 7.9Experimental & Molecular MedicineOA

Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bact

Molecular BiologyBiochemistry, Genetics and Molecular Biology
3
논문|인용수 170·2018
Smart Machining Process Using Machine Learning: A Review and Perspective on Machining Industry
김동현, Thomas J. Y. Kim, Xinlin Wang, 김민철, 전영준, 오진우, 민수홍, 김형중, Binayak Bhandari, 양인순, 안성훈
http://link.springer.com/article/10.1007/s40684-018-0057-y

The Fourth Industrial Revolution incorporates the digital revolution into the physical world, creating a new direction in a number of fields, including artificial intelligence, quantum computing, nanotechnology, biotechnology, robotics, 3D printing, autonomous vehicles, and the Internet of Things. The artificial intelligence field has encountered a turning point mainly due to advancements in machine learning, which allows machines to learn, improve, and perform a specific task through data witho

4
논문|인용수 117·2016
Nod2-mediated recognition of the microbiota is critical for mucosal adjuvant activity of cholera toxin
Dong-Hyun Kim, Yun‐Gi Kim, Sang‐Uk Seo, Dong‐Jae Kim, Nobuhiko Kamada, David Prescott, Mathias Chamaillard, Dana J. Philpott, Philip Rosenstiel, Naohiro Inohara, Gabriel Núñez
SJR Q1FWCI 7.8Nature Medicine
Infectious DiseasesMedicine
5
논문|인용수 115·2001
Production of a hypoglycemic, extracellular polysaccharide from the submerged culture of the mushroom, Phellinus linteus
Dong-Hyun Kim, Byung-Keun Yang, Sang‐Chul Jeong, Jun-Bo Park, Sung-Pill Cho, Surajit Das, Jong Won Yun, Chi‐Hyun Song
SJR Q2FWCI 3.9Biotechnology Letters
PharmacologyMedicine
6
논문|인용수 92·2017
The interplay between host immune cells and gut microbiota in chronic inflammatory diseases
김동현, Melody Y Zeng, Gabriel Núñez

Many benefits provided by the gut microbiota to the host rely on its intricate interactions with host cells. Perturbations of the gut microbiota, termed gut dysbiosis, affect the interplay between the gut microbiota and host cells, resulting in dysregulation of inflammation that contributes to the pathogenesis of chronic inflammatory diseases, including inflammatory bowel disease, multiple sclerosis, allergic asthma and rheumatoid arthritis. In this review, we provide an overview of how gut bact

7
리뷰|인용수 78·2016
Gut microbiota in autoimmunity: potential for clinical applications
Dong-Hyun Kim, Seung‐Ah Yoo, Wan‐Uk Kim
SJR Q1FWCI 3.5Archives of Pharmacal Research
Molecular BiologyBiochemistry, Genetics and Molecular Biology
8
논문|인용수 57·1995
Soft Magnetic Films by Electroless Ni‐Co‐P Plating
Dong‐Hyun Kim, Koji AOKI, Osamu TAKANO
SJR Q1FWCI 1.6Journal of The Electrochemical Society

An electroless Ni‐Co‐P plating solution was developed for preparing soft magnetic thin films. In this plating process, the optimum bath composition and operating condition were obtained by investigating the effect of operating conditions on deposition rate, film composition, and magnetic properties. Soft magnetic films with low coercive force (lower than ) and high squareness (higher than 0.8) were prepared from these electroless Ni‐Co‐P plating processes. The alloy film deposited from the optim

Electrical and Electronic EngineeringEngineering
9
논문|인용수 51·2008
Anti‐allergic effects of PG102, a water‐soluble extract prepared from <i>Actinidia arguta</i>, in a murine ovalbumin‐induced asthma model
Dong-Hyun Kim, S. H. Kim, E‐J. Park, CY Kang, Sang‐Heon Cho, Sanghee Kim
SJR Q1FWCI 2.6Clinical & Experimental Allergy

PG102 may have potential as a safe and effective reagent for the prevention or treatment of asthma.

PhysiologyMedicine
10
논문|인용수 51·2021
Automated Vertebral Segmentation and Measurement of Vertebral Compression Ratio Based on Deep Learning in X-Ray Images
Dong Hyun Kim, Jin Gyo Jeong, Young Jae Kim, Kwang Gi Kim, Ji Young Jeon
SJR Q2FWCI 3.0Journal of Digital ImagingOA

Vertebral compression fracture is a deformity of vertebral bodies found on lateral spine images. To diagnose vertebral compression fracture, accurate measurement of vertebral compression ratio is required. Therefore, rapid and accurate segmentation of vertebra is important for measuring the vertebral compression ratio. In this study, we used 339 data of lateral thoracic and lumbar vertebra images for training and testing a deep learning model for segmentation. The result of segmentation by the m

Biomedical EngineeringEngineering
11
논문|인용수 49·2007
Factors influencing varicella zoster virus infection after allogeneic peripheral blood stem cell transplantation: low‐dose acyclovir prophylaxis and pre‐transplant diagnosis of lymphoproliferative disorders
Dong-Hyun Kim, Hans A. Messner, Mark D. Minden, Vikas Gupta, John Kuruvilla, James R. Wright, Jeffrey H. Lipton
SJR Q2FWCI 1.8Transplant Infectious Disease

The incidence of VZV infection after PBSCT was high at 36.8%, with patients transplanted for LPDs at higher risk. The long-term use of low-dose acyclovir may be protective for VZV infection, although it does not completely prevent rebound of late VZV infection.

EpidemiologyMedicine
12
논문|인용수 48·2014
In vitro biodegradable and mechanical performance of biphasic calcium phosphate porous scaffolds with unidirectional macro-pore structure
Dong‐Hyun Kim, Kyeong-Lok Kim, Ho-Hwan Chun, Tae-Wan Kim, Hong-Chae Park, Seog-Young Yoon
SJR Q1FWCI 4.2Ceramics International
Biomedical EngineeringEngineering
13
논문|인용수 47·2010
The Comparison between Torsional and Conventional Mode Phacoemulsification in Moderate and Hard Cataracts
Dong-Hyun Kim, Won-Ryang Wee, Jin-Hak Lee, Mee Kum Kim
SJR Q2FWCI 3.7Korean Journal of OphthalmologyOA

Torsional phacoemulsification showed superior efficiency for moderate cataracts, as compared with longitudinal phacoemulsification, in the early postoperative stage.

OphthalmologyMedicine
14
논문|인용수 45·2010
Fine mapping of a resistance gene to bacterial leaf pustule in soybean
Dong Hyun Kim, Kil Hyun Kim, Kyujung Van, Moon Young Kim, Suk‐Ha Lee
SJR Q1FWCI 2.9Theoretical and Applied Genetics
Plant ScienceAgricultural and Biological Sciences
15
논문|인용수 45·2009
Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy
Dong-Hyun Kim, Wei Xu, Suzanne Kamel‐Reid, X. Liu, Chul Won Jung, S. Kim, Jeffrey H. Lipton
SJR Q1FWCI 1.5Annals of OncologyOA
HematologyMedicine

대표 연구 분야

Biomedical EngineeringMolecular BiologyRadiology, Nuclear Medicine and ImagingFood ScienceElectrical and Electronic EngineeringEpidemiology

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