강동완 교수
Dong-Wan Kang
서울대학교 · 의학
연구실 소개
강동완 교수의 연구실은 뇌혈관 질환의 조기 진단과 치료 전략 개발에 초점을 맞추고 있습니다. 특히 자기공명영상 기반의 혈관 영상 기술과 나노입자를 활용한 신경보호 치료제 개발을 통해 뇌출혈, 뇌경색 등 치명적인 뇌혈관 질환의 병태생리적 메커니즘을 규명하고 있습니다. 또한, 신경재생을 위한 나노소재 기반의 신경유도관 및 안과 수술에 활용되는 해부학적 기초 연구도 병행하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Increased SVS diameter on susceptibility-weighted magnetic resonance imaging may predict cardioembolism. No clear association was found between SVS volume and endovascular recanalization.
Intracerebral hemorrhage (ICH) is a devastating subtype of stroke with a high mortality rate, for which there currently is no effective treatment. A perihematomal edema caused by an intense inflammatory reaction is more deleterious than the hematoma itself and can result in neurological deterioration and death. Ceria nanoparticles (CeNPs) are potent free radical scavengers with potential for biomedical applications. As oxidative stress plays a major role in post-ICH inflammation, we hypothesized
Intracranial arterial disease (ICAD) is a heterogeneous condition characterized by distinct pathologies, including atherosclerosis. Advances in magnetic resonance technology have enabled the visualization of intracranial arteries using high-resolution vessel wall imaging (HR-VWI). This review summarizes the anatomical, embryological, and histological differences between the intracranial and extracranial arteries. Next, we review the heterogeneous pathophysiology of ICAD, including atherosclerosi
Radial MPLD is effective for analyzing eyelid contour. In our study, lateral flare of upper lid retraction and flat appearance of lower lid retraction were distinct characteristics in patients with TED. Consideration of eyelid contour in patients with TED may improve corrective surgery for eyelid retraction.
Artificial nerve guidance conduits (aNGCs) prepared from polymer scaffolds and carbon nanotubes (CNTs) possess unique chemical and physical properties, and have been widely used in preclinical trials to promote neuronal differentiation and growth. However, there have been only a few reports on the clinical applicability of CNT sheets for proliferation of primary neuronal cells due to safety concerns. The present study assesses the ability and potential applicability of multiwalled CNTs (MWNTs) c
In comprising the lacrimal sac fossa, the maxillary bone accounted for a bigger proportion than the lacrimal bone. Male maxillary bone thickness was greater than female thickness. The authors also observed that maxillary bone thickness increased toward the upper areas of the lacrimal sac fossa and with increasing subject age. Understanding the form and variation of a normal lacrimal sac fossa is helpful for preparing for a successful osteotomy with endoscopic dacryocystorhinostomy.
We propose a weighted ensemble model for ICH detection, trained on large-scale, strongly annotated CT scans, as no model can capture all aspects of complex tasks.
CRAO-E<sup>+</sup> was found to be associated with a better outcome. CRAO-E<sup>+</sup> may be more prone to recanalization than that CRAO-E<sup>-</sup>.
The JLK-ICH algorithm demonstrated high accuracy in detecting all ICH subtypes. Non-expert readers significantly improved diagnostic accuracy for brain CT scans with deep learning assistance.
Different degenerative features according to MNV in fellow eyes of patients with AMD and SDDs suggest that variable degenerative features might be present during disease progression and have an association with the phenotype.
Ocular cranial nerve palsy of presumed ischemic origin (OCNPi) is the most common type of ocular cranial nerve palsy (OCNP) in patients aged ≥ 50 years; however, no definite diagnostic test exists. As diagnostic criteria include clinical improvement, diagnoses are often delayed. Diagnostic biomarkers for OCNPi are required; we hypothesized that cerebral small vessel disease is associated with OCNPi. We analyzed 646 consecutive patients aged ≥ 50 years with isolated unilateral OCNP who underwent
문 형태로 신생아를 포함한 어떤 연령대에서도 발생할 수 있으 며, 전체 뇌졸중의 0.5-1%를 차지한다. 최근 급성 혹은 아급성 두통과 새로 발생한 발작(seizure) 환자에서의 자기공명영상 등 영상 진단 장치의 사용이 늘어나면서, 뇌정맥혈전증으로 진단되 는 환자 수가 늘어나고 있다. 뇌정맥혈전증의 위험인자는 크게 유전적 위험인자와 후천적 위험인자로 분류되며, 전자는 C단백 질결핍(protein C deficiency), S단백질결핍(protein S deficiency) 을 포함한 혈전유발성 경향, 결체조직질환 등이 있고, 후자는 수 술, 감염, 외상, 임신, 산욕기, 암, 외인성 호르몬, 약물, 항인지질 항체증후군(antiphospholipid antibody syndrome) 등이 있다. 저자들은 다른 유발 요인 없이 finasteride 복용에 의해 유발 된 뇌정맥혈전증 환자를 경험하여 보고하고자 한다.
연구 목적: 대한치과보철학회지의 최근 5년간 게재된 논문 중에서 통계 방법이 사용된 논문의 빈도를 조사하고 통계 방법의 종류 및 오류의 유형과 빈도를 살펴 보고 오류별 적절한 통계 방법을 제시하고 통계분석 가이드라인을 개발하여 대한치과보철학회지의 학술적 발전에 기여하고자 한다. 연구 재료 및 방법: 2006년부...
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