김도순 교수
Doo-Sun Kim
서울대학교 · 생화학·유전·분자생물학
연구실 소개
김도순 교수의 연구실은 주로 식물 유전체와 기능유전체를 기반으로 한 고부가가치 작물의 유전자 기반 품종 개선을 목표로 합니다. 수박과 딸기의 주요 영양소 및 기능성 성분(리코펜, 시트룰린 등)과 관련된 유전자 기반 메커니즘을 규명하고, 특히 딸기의 색소 형성과 광합성 효율 향상을 위한 유전자 지도 및 QTL 분석을 중심으로 연구를 진행하고 있습니다. 또한 식물 유전자를 이용한 유전자 조작을 통한 치료용 백신 개발 등 식물 바이오 기반 의료 신소재 개발에도 기여하고 있습니다.
연구 현황
연구 성과 추이
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주요 논문
15Watermelon (<i>Citrulus lantus</i>) is an important horticultural crop which belongs to the Curcubitaceae family. The nutraceutical potential of watermelon has been illustrated by several researchers, which makes it a better choice of functional food. Watermelon has been used to treat various ailments, such as cardio-vascular diseases, aging related ailments, obesity, diabetes, ulcers, and various types of cancers. The medicinal properties of watermelon are attributed by the presence of importan
Strawberry is an allo-octoploid crop with high genome heterozygosity and complexity, which hinders the sequencing and the assembly of the genome. However, in the present study, we have generated a chromosome level assembly of octoploid strawberry sourced from a highly homozygous inbred line 'Wongyo 3115', using long- and short-read sequencing technologies. The assembly of 'Wongyo 3115' produced 805.6 Mb of the genome with 323 contigs scaffolded into 208 scaffolds with an N50 of 27.3 Mb after fur
The genus <i>Fragaria</i> encompass fruits with diverse colors influenced by the distribution and accumulation of anthocyanin. Particularly, the fruit colors of strawberries with different ploidy levels are determined by expression and natural variations in the vital structural and regulatory genes involved in the anthocyanin pathway. Among the regulatory genes, MYB10 transcription factor is crucial for the expression of structural genes in the anthocyanin pathway. In the present study, we perfo
Chlorophyll is an important factor facilitating plants to capture, allocate and transforms light energy and plays a major role in yield formation. Strawberry is one of the most important fruit crops worldwide. Breeding strawberry for better light utilization by improving photosynthetic efficiency can improve the yield potential. In strawberry, genetic studies have been done for several traits, but no reports on the genetic mapping of chlorophyll content in leaves. In the present study, we used t
See Article on Page 78-82 The ultimate purpose of surgical treatment for an anal fistula is the eradication of sepsis while maintaining continence. To achieve these goals, it is essential to identify the internal opening, as well as the relationship between the fistula tract and the sphincters, before or at the time of surgery. When the internal opening is not identified or is misdiagnosed, recurrence and unnecessary sphincter injury may be the result. Accurate diagnosis of the type of fistul
The epithelial cell adhesion molecule (EpCAM) is a tumor-associated antigen and a potential target for tumor vaccine. The EpCAM is a cell-surface glycoprotein highly expressed in colorectal carcinomas. The objective of the present study is to develop an edible vaccine system through <i>Agrobacterium</i>-mediated transformation in Chinese cabbage (<i>Brassica rapa</i>). For the transformation, two plant expression vectors containing genes encoding for the EpCAM recombinant protein along with the
See Article on Page 192-196 The aim of surgical treatment for an anal fistula is to cure the disease, as well as to preserve continence. Treatment of a complex anal fistula has been a surgical challenge. Therefore, various sphincter-preserving procedures have been introduced for its treatment due to concerns of incontinence. One of the oldest and most widely performed procedures is the advancement flap. The procedure of an advancement flap may be summarized as elevating a flap, coring out
Marker-assisted background selection is a powerful molecular tool that can enhance breeding efficiency through the analysis of a large number of markers representing the entire genomic background for precise selection. In the present study, the transcriptomes of 38 cucumber inbred lines with diverse traits were sequenced for single nucleotide polymorphism (SNP) mining for practical application to commercial cucumber breeding. A total of 62,378 high-quality SNPs were identified, of which 2462 SNP
Bolting time is a critical trait that affects crop yield, adaptability, and overall productivity, making its regulation vital for agricultural success. In this study, we explored the genetic mechanisms controlling flowering time in radish (Raphanus sativus) via a combination of quantitative trait locus (QTL) analysis and genome-wide association study (GWAS). By developing an F2 population from a cross between the relatively late-bolting variety ‘L432’ and the early-bolting variety ‘L285’, we ide
Ogura male sterile cytoplasm is widely used for radish breeding. In this study, high-resolution melting (HRM) markers associated with Rft and Rfo, major restorer-of-fertility genes in Ogura cytoplasmic male sterility (CMS) in radish, were developed. Genetic mapping was carried out using F2 populations derived from crosses between male-sterile Ogura CMS lines and male-fertile lines. Identification of the Rft and Rfo loci was achieved through SNP-based genotyping and linkage grouping. HRM markers
최근 국내에서 온라인에서의 사적제재가 광범위하게 발생하고 있다. 사적제재는 정당한 법적 절차를 거치지 않고 개인이나 집단이 특정인을 응징하는 행위로, 무고한 피해자가 발생할 수 있다는 점에서 상당히 심각한 사회 문제로 대두되고 있다. 따라서 국내의 사적제재의 특성을 파악하여 이에 적합한 대응 방안 모색이 요구된다. 특히, 파편화된 개인이 참여하는 온라인 환경의 특성을 고려하여 개인의 사회심리적 요인이 사적제재 참여에 대한 영향을 실증적으로 확인하고자 하였다. 이를 위해 이 연구는 국내 성인 1,000명을 대상으로 설문조사를 수행하였다. 분석 결과, 샤덴프로이데와 도덕적 과시 수준이 높아질수록 사적제재 참여 역시 증가하고, 공정세상신념 중 일반적 분배공정성 믿음이 높을수록 사적제재 참여는 낮아지는 것으로 나타났다. 또한 연령대가 온라인 사적제재 경험에 강한 영향을 미치는 것으로 나타났다. 한편, 공정세상신념은 온라인 사적제재의 관계에서 도덕적 과시를 매개하여 간접적인 영향을 미칠 가능
See Article on Page 55-59 The article is interesting enough to draw the attention of surgeons because the intersphincteric approach for the treatment of deep postanal sepsis seems to be a novel procedure. The deep postanal space is clinically significant because it can provide routes for the extension of an infection when a cryptoglandular infection enters into this potential space, complicating treatment, potentially leaving a severe deformity and possibly compromising continence when conven
AI technology is increasingly being explored as a strategic tool for enhancing security. However, concerns surrounding privacy infringement and inherent biases in such technologies have raised significant challenges to their widespread acceptance. Real-time facial recognition and object recognition systems, in particular, necessitate public empathy and support to function effectively. Police legitimacy and procedural justice have emerged as critical mechanisms for fostering public trust and coop
The jury in the public participation trial selected from the general public is a non-expert in scientific investigation and can feel considerable difficulty in determining the proof of evidence. The general public indirectly experiences the process of proof of facts in criminal proceedings through the media. This study attempted to examine the media effect on the judgment of the proof of evidence. To this end, the Forensic Evidence Evaluation Bias(FEEB) scale was introduced and used for analysis
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