정두현 교수
Du-Hyun Jung
서울대학교 · 의학
연구실 소개
정두현 교수의 연구실은 면역세포와 종양 미세환경의 상호작용을 중심으로, 암의 진행 메커니즘과 면역관문 억제 치료의 내인성 조절 기전을 규명하는 데 초점을 맞추고 있습니다. 특히 EML4-ALK 변연이 PD-L1 발현에 미치는 영향, ILC 세포의 분화 전환과 IL-17 매개 종양 진행, 그리고 TLR2와 IRF5 등 면역 조절 전달 경로의 분자 기전을 다룹니다. 또한 Treg 세포와 NKT 세포의 기능 조절 메커니즘을 통해 만성 폐질환과 암의 면역 회피 기전을 밝히는 데 기여하고 있습니다.
면역세포 분화PD-L1 조절면역관문 억제Treg 세포 기능암 미세환경
연구 현황
논문 수
422
총 인용 수
13,226
최근 5년 논문
127
주요 분야
의학
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
5개년 연도별 논문 게재 수
127총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
314총합
20222023202420252026
주요 논문
151
논문|인용수 214·2010
High MET Gene Copy Number Leads to Shorter Survival in Patients with Non-small Cell Lung CancerHeounjeong Go, Yoon Kyung Jeon, Hyo Jin Park, Sook-Whan Sung, Jeong‐Wook Seo, Doo Hyun Chung
SJR Q1FWCI 12.5Journal of Thoracic OncologyOA
Pulmonary and Respiratory MedicineMedicine
2
논문|인용수 186·2015
Clinicopathological analysis of PD-L1 and PD-L2 expression in pulmonary squamous cell carcinoma: Comparison with tumor-infiltrating T cells and the status of oncogenic driversMoon‐Young Kim, Jaemoon Koh, Sehui Kim, Heounjeong Go, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 14.9Lung Cancer
OncologyMedicine
3
논문|인용수 181·2015
Programmed death-1 ligand 1 and 2 are highly expressed in pleomorphic carcinomas of the lung: Comparison of sarcomatous and carcinomatous areasSehui Kim, Moon‐Young Kim, Jaemoon Koh, Heounjeong Go, Dong Soo Lee, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 13.4European Journal of Cancer
Pulmonary and Respiratory MedicineMedicine
4
논문|인용수 165·2016
PD-L1 expression is associated with epithelial-to-mesenchymal transition in adenocarcinoma of the lungSehui Kim, Jaemoon Koh, Moon‐Young Kim, Dohee Kwon, Heounjeong Go, Young A Kim, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 9.0Human Pathology
OncologyMedicine
5
논문|인용수 159·2015
Clinicopathologic analysis of programmed cell death-1 and programmed cell death-ligand 1 and 2 expressions in pulmonary adenocarcinoma: comparison with histology and driver oncogenic alteration statusJaemoon Koh, Heounjeong Go, Bhumsuk Keam, Moon‐Young Kim, Soo Jeong Nam, Tae Min Kim, Se‐Hoon Lee, Hye Sook Min, Young Tae Kim, Dong‐Wan Kim, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 17.5Modern PathologyOA
Pulmonary and Respiratory MedicineMedicine
6
논문|인용수 148·2015
EML4-ALK enhances programmed cell death-ligand 1 expression in pulmonary adenocarcinoma via hypoxia-inducible factor (HIF)-1α and STAT3Jaemoon Koh, Ji-Young Jang, Bhumsuk Keam, Sehui Kim, Moon‐Young Kim, Heounjeong Go, Tae Min Kim, Dong‐Wan Kim, Chul Woo Kim, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 7.2OncoImmunologyOA
Programmed cell death (PD)-1/PD-1 ligand-1 (PD-L1)-targeted therapy has emerged as a promising therapeutic strategy for lung cancer. However, whether EML4-ALK regulates PD-L1 expression in lung cancer remains unknown. A total of 532 pulmonary adenocarcinomas (pADCs), including 58 <i>ALK</i>-translocated tumors, were immunohistochemically evaluated for PD-L1 and PD-1. H23 (<i>EGFR</i><sup>Wild-type</sup><i>EML4-ALK</i><sup>-</sup>PD-L1<sup>Low</sup>) and H2228 (<i>EGFR</i><sup>Wild-type</sup><i>E
Pulmonary and Respiratory MedicineMedicine
7
논문|인용수 104·2017
Comparative analysis of PD-L1 expression between primary and metastatic pulmonary adenocarcinomasSehui Kim, Jaemoon Koh, Dohee Kwon, Bhumsuk Keam, Heounjeong Go, Young A Kim, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 6.7European Journal of Cancer
OncologyMedicine
8
논문|인용수 94·2003
Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lungSeong Ho Yoo, Young Sik Park, Hyeong-Ryul Kim, Sook Whan Sung, Joo Hyun Kim, Young Soo Shim, Soong Deok Lee, Yoon‐La Choi, Min Kyung Kim, Doo Hyun Chung
SJR Q1FWCI 1.0Lung Cancer
Cell BiologyBiochemistry, Genetics and Molecular Biology
9
논문|인용수 93·2005
Natural Killer T (NKT) Cells Attenuate Bleomycin-Induced Pulmonary Fibrosis by Producing Interferon-γJi Hyung Kim, Hye Young Kim, Sanghee Kim, Jin-Haeng Chung, Weon Seo Park, Doo Hyun Chung
SJR Q1FWCI 1.9American Journal Of PathologyOA
ImmunologyImmunology and Microbiology
10
논문|인용수 87·2006
Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancerYoon Kyung Jeon, Sook-Whan Sung, Jin-Haeng Chung, Weon Seo Park, Jeong‐Wook Seo, Chul Woo Kim, Doo Hyun Chung
SJR Q1FWCI 9.6Lung Cancer
Pulmonary and Respiratory MedicineMedicine
11
논문|인용수 78·2019
IL23-Producing Human Lung Cancer Cells Promote Tumor Growth via Conversion of Innate Lymphoid Cell 1 (ILC1) into ILC3Jaemoon Koh, Hye Young Kim, Youngha Lee, In Kyu Park, Chang Hyun Kang, Young Tae Kim, Ji-Eun Kim, Murim Choi, Won‐Woo Lee, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 4.9Clinical Cancer ResearchOA
Conversion from ILC1 into ILC3 by IL23-producing SqCCs promotes IL17-mediated tumor progression, resulting in a poor prognosis.
ImmunologyImmunology and Microbiology
12
논문|인용수 66·2020
Effects of B7-H3 expression on tumour-infiltrating immune cells and clinicopathological characteristics in non–small-cell lung cancerJeemin Yim, Jaemoon Koh, Sehui Kim, Seung Geun Song, Hyun Kyung Ahn, Young A Kim, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 3.5European Journal of Cancer
OncologyMedicine
13
논문|인용수 65·2018
Overexpression of endoplasmic reticulum stress-related proteins, XBP1s and GRP78, predicts poor prognosis in pulmonary adenocarcinomaDohee Kwon, Jaemoon Koh, Sehui Kim, Heounjeong Go, Hye Sook Min, Young A Kim, Deog Kyeom Kim, Yoon Kyung Jeon, Doo Hyun Chung
SJR Q1FWCI 4.0Lung Cancer
Cell BiologyBiochemistry, Genetics and Molecular Biology
14
논문|인용수 62·1998
ILK (?1-integrin-linked protein kinase): a novel immunohistochemical marker for Ewing's sarcoma and primitive neuroectodermal tumourDoo Hyun Chung, Jong Im Lee, Jeong Ran Kim, Seong Hoe Park, Hyung Geun Song, Myeong‐Cherl Kook, Soon Ha Kim, Eun Young Choi
SJR Q1FWCI 1.4Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin
Immunology and AllergyMedicine
15
논문|인용수 61·2012
IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent mannerHyun-Seok Kim, Doo Hyun Chung
SJR Q1FWCI 1.9Mucosal ImmunologyOA
ImmunologyImmunology and Microbiology
대표 연구 분야
Pulmonary and Respiratory MedicineImmunologyOncologyMolecular BiologyCell BiologyCancer Research
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