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노두현 교수

Du Hyun Ro

서울대학교 · 의학

연구실 소개

노두현 교수의 연구실은 노화 및 퇴행성 관절질환, 특히 골관절염의 생체역학적 기전과 세포 기반 치료 전략을 중심으로 연구를 진행하고 있습니다. 특히 무릎 골관절염 환자에서 하지 관절의 기계적 부담과 전반적인 움직임 변화를 분석하며, 하지 전이 운동학적 영향을 규명하고 있습니다. 또한 노화와 관련된 세포성 고갈세포(스네스넷 세포)의 특성과 표면 마커를 규명하여, 향후 정밀 치료 타겟으로 삼을 수 있는 생물학적 기반을 마련하고 있습니다. 이와 더불어 주로 하지 혈관질환의 조기 진단 기술 평가에도 관심을 기울이고 있습니다.

골관절염노화 관련 세포기계적 부담생체역학혈관질환 진단

연구 현황

논문 수
141
총 인용 수
2,193
최근 5년 논문
91
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
91총합
2021
2022
2023
2024
2025
5개년 연도별 피인용 수
775총합
20212022202320242025

주요 논문

15
1
논문|인용수 79·2019
Effects of Knee Osteoarthritis on Hip and Ankle Gait Mechanics
Du Hyun Ro, Joonhee Lee, Jangyun Lee, Jae‐Young Park, Hyuk‐Soo Han, Myung Chul Lee
SJR Q3FWCI 7.4Advances in OrthopedicsOA

Knee OA has a negative effect on the ROM, coronal motion arc, and joint moment of the ankle joint and hip joint. As knee OA is associated with increased moment of the ankle joint, attention should be paid to the ankle joint when treating patients with knee OA.

RheumatologyMedicine
2
논문|인용수 60·2018
The use of bisphosphonates after joint arthroplasty is associated with lower implant revision rate
Du Hyun Ro, Heejin Jin, Jae Young Park, Myung Chul Lee, Sungho Won, Hyuk‐Soo Han
SJR Q1FWCI 2.6Knee Surgery Sports Traumatology Arthroscopy

Retrospective cohort study, Level III.

SurgeryMedicine
3
논문|인용수 50·2016
Sex differences in knee joint loading: Cross-sectional study in geriatric population
Du Hyun Ro, Dong Yeon Lee, Giho Moon, Sahnghoon Lee, Sang Gyo Seo, Seong Hwan Kim, In Woong Park, Myung Chul Lee
SJR Q1FWCI 2.4Journal of Orthopaedic Research®OA

This study investigated sex differences in knee biomechanics and investigated determinants for difference in a geriatric population. Age-matched healthy volunteers (42 males and 42 females, average age 65 years) without knee OA were included in the study. Subjects underwent physical examination on their knee and standing full-limb radiography for anthropometric measurements. Linear, kinetic, and kinematic parameters were compared using a three-dimensional, 12-camera motion capture system. Gait p

RheumatologyMedicine
4
논문|인용수 39·2012
Photoplethysmography and Continuous-Wave Doppler Ultrasound as a Complementary Test to Ankle–Brachial Index in Detection of Stenotic Peripheral Arterial Disease
Du Hyun Ro, Hyuk Ju Moon, Ji Hyeung Kim, Kyoung Min Lee, Sung Ju Kim, Dong Yeon Lee
SJR Q2FWCI 1.5Angiology

Purpose: We evaluated the sensitivity and specificity of ankle–brachial index (ABI), photoplethysmography (PPG), and continuous-wave Doppler ultrasound (CWD) in the detection of anatomically stenotic peripheral arterial disease (PAD). Methods: Ninety-seven patients (194 legs) patients who had coincidentally undergone computed tomography angiography (CTA), ABI, PPG, and CWD for the evaluation of PAD were retrospectively reviewed. Sensitivity and specificity were measured. Results: Among 194 legs,

SurgeryMedicine
5
논문|인용수 36·2017
Slow gait speed after bilateral total knee arthroplasty is associated with suboptimal improvement of knee biomechanics
Du Hyun Ro, Hyuk‐Soo Han, Dong Yeon Lee, Seong Hwan Kim, Yoon-Ho Kwak, Myung Chul Lee
SJR Q1FWCI 2.2Knee Surgery Sports Traumatology Arthroscopy

Retrospective cohort study, Level III.

SurgeryMedicine
6
논문|인용수 20·2019
Quantitative evaluation of gait features after total knee arthroplasty: Comparison with age and sex-matched controls
Du Hyun Ro, Tae Hoon Kang, Do Hwan Han, Dong Yeon Lee, Hyuk‐Soo Han, Myung Chul Lee
SJR Q1FWCI 1.5Gait & Posture
SurgeryMedicine
7
논문|인용수 17·2022
Mechanism of action of genicular artery embolization in a rabbit model of knee osteoarthritis
Du Hyun Ro, Myoung‐jin Jang, Jaemoon Koh, Won Seok Choi, Hyo‐Cheol Kim, Hyuk‐Soo Han, Jin Woo Choi
SJR Q1FWCI 2.6European Radiology
RheumatologyMedicine
8
논문|인용수 17·2024
Selective targeting of dipeptidyl‐peptidase 4 (DPP‐4) positive senescent chondrocyte ameliorates osteoarthritis progression
Du Hyun Ro, Gun Hee Cho, J. Kim, Seongki Min, Ha Ru Yang, Hee Jung Park, Sun Young Wang, You Jung Kim, Myung Chul Lee, Hyun Cheol Bae, Hyuk‐Soo Han
SJR Q1FWCI 4.8Aging CellOA

Senescent cells increase in many tissues with age and induce age-related pathologies, including osteoarthritis (OA). Senescent chondrocytes (SnCs) are found in OA cartilage, and the clearance of those chondrocytes prevents OA progression. However, targeting SnCs is challenging due to the absence of a senescent chondrocyte-specific marker. Therefore, we used flow cytometry to screen and select senescent chondrocyte surface markers and cross-validated with published transcriptomic data. Chondrocyt

OncologyMedicine
9
논문|인용수 17·2019
Residual varus alignment after total knee arthroplasty increases knee adduction moment without improving patient function: A propensity score-matched cohort study
Du Hyun Ro, Jong-Keun Kim, Do Weon Lee, Jangyun Lee, Hyuk‐Soo Han, Myung Chul Lee
SJR Q2FWCI 3.1The Knee
SurgeryMedicine
10
논문|인용수 16·2023
Age and sex differences in coronal lower extremity alignment in a healthy Asian population
Doohyun Hwang, Min-Wook Choi, Seong-Hwan Kim, Hyuk‐Soo Han, Chong Bum Chang, Myung Chul Lee, Na-Kyoung Lee, Du Hyun Ro
SJR Q2FWCI 5.1The Knee
SurgeryMedicine
11
논문|인용수 13·2022
Deep Learning-Based Muscle Segmentation and Quantification of Full-Leg Plain Radiograph for Sarcopenia Screening in Patients Undergoing Total Knee Arthroplasty
Doohyun Hwang, Sung-Ho Ahn, Yong‐Beom Park, Seong Hwan Kim, Hyuk‐Soo Han, Myung Chul Lee, Du Hyun Ro
SJR Q1FWCI 1.3Journal of Clinical MedicineOA

Sarcopenia, an age-related loss of skeletal muscle mass and function, is correlated with adverse outcomes after some surgeries. Here, we present a deep-learning-based model for automatic muscle segmentation and quantification of full-leg plain radiographs. We illustrated the potential of the model to predict sarcopenia in patients undergoing total knee arthroplasty (TKA). A U-Net-based deep learning model for automatic muscle segmentation was developed, trained and validated on the plain radiogr

PhysiologyMedicine
12
논문|인용수 13·2022
Automated Detection of Surgical Implants on Plain Knee Radiographs Using a Deep Learning Algorithm
Back Kim, Do Weon Lee, Sanggyu Lee, Sunho Ko, Changwung Jo, Jaeseok Park, Byung Sun Choi, Aaron J. Krych, Ayoosh Pareek, Hyuk‐Soo Han, Du Hyun Ro
SJR Q2FWCI 2.2MedicinaOA

<i>Background and Objectives</i>: The number of patients who undergo multiple operations on a knee is increasing. The objective of this study was to develop a deep learning algorithm that could detect 17 different surgical implants on plain knee radiographs. <i>Materials and Methods</i>: An internal dataset consisted of 5206 plain knee antero-posterior X-rays from a single, tertiary institute for model development. An external set contained 238 X-rays from another tertiary institute. A total of

SurgeryMedicine
13
논문|인용수 13·2015
Value of SPECT-CT Imaging for Middle-Aged Patients with Chronic Anterior Knee Pain
Du Hyun Ro, Ho‐Young Lee, Chong Bum Chang, Seung‐Baik Kang
SJR Q2FWCI 0.5BMC Musculoskeletal DisordersOA

Increased subchondral bone metabolism in the patella is associated with responsiveness to conservative therapy. SPECT-CT can benefit clinicians by predicting the treatment response from conservative management.

Biomedical EngineeringEngineering
14
논문|인용수 12·2018
Periprosthetic Joint Infection Does Not Preclude Good Outcomes after a Revision Total Knee Arthroplasty: A 7-Year Follow-Up Study of 144 Retrospective Cases
Du Hyun Ro, Jong-Keun Kim, Sunghwan Kim, Hyuk‐Soo Han, Myung Chul Lee
SJR Q2FWCI 1.4BioMed Research InternationalOA

Clinical outcomes of septic revision were inferior to those of aseptic revision. However, poor outcomes were mainly associated with large bone defects and an increased number of surgeries. The outcomes of aseptic and septic revision surgery were similar when patients with larger bone defects and more than three surgeries were excluded.

SurgeryMedicine
15
논문|인용수 10·2024
Prediction of postoperative gait speed change after bilateral primary total knee arthroplasty in female patients using a machine learning algorithm
Do Weon Lee, Hyuk‐Soo Han, Myung Chul Lee, Du Hyun Ro
SJR Q1FWCI 5.7Orthopaedics & Traumatology Surgery & Research
SurgeryMedicine

대표 연구 분야

SurgeryRheumatologyBiomedical EngineeringBiochemistryCritical Care and Intensive Care MedicineHealth Informatics

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