이은희 교수

The acquisition of tamoxifen resistance is a major therapeutic problem in breast cancer. We developed a tamoxifen-resistant MCF-7 (TRM-7) cell line to elucidate the molecular mechanisms and factors associated with acquisition of such resistance. We showed that phosphorylation of STAT3 at tyrosine 705 (Y705) and RANTES expression are increased in response to tamoxifen in human breast cancer cells. On the basis of these results, we hypothesize that upregulated STAT3 phosphorylation and RANTES may

Three studies explored whether social power affects the perception of physical properties of objects, testing the hypothesis that the powerless find objects to be heavier than the powerful do. Correlational findings from Study 1 revealed that people with a low personal sense of power perceived loaded boxes to be heavier than people with a high personal sense of power perceived them to be. In Study 2, experimentally manipulated power indicated that participants in the powerless condition judged t

Objectives: This study was performed to investigate the relationship between job stress and the type of turnover of registered nurses in a university hospital. Methods: A total of 553 registered nurses who left the hospital between 1994 and 2005 were surveyed, and aninterview record and self-administered questionnaire completed at the time of the turnover were used to assess the relationship. Job stress was categorized into four sub-scales (factor Ⅰ: insufficient work authority and lack of auton

A methane-oxidizing bacterium was isolated from the enriched culture of a landfill cover soil. The closest relative of the isolate, designated M6, is Methylocystis sp. Based on a kinetic analysis, the maximum specific methane oxidation rate and saturation constant were 4.93 mmol·g--dry cell weight--1·h⁻¹ and 23 microM, respectively. This was the first time a kinetic analysis was performed using pure methanotrophic culture. The methane oxidation by M6 was investigated in the presence of aromatic

With a growing need for usable land in urban areas, subterranean development has been gaining attention. While construction of large underground complexes is not a new concept, our understanding of various socio-cultural aspects of staying underground is still at a premature stage. With projected emergence of underground built environments, future populations may spend much more of their working, transit, and recreational time in underground spaces. Therefore, it is essential to understand the c

Over half of the global population lives in urban areas, making the issue of space a pressing environmental factor. The development of large-scale underground complexes in (mega-)cities is a solution to healthy urban growth and many governments have already adopted the development of underground (office) workspaces (UWS). Engineering can develop such high quality spaces; yet, there is limited understanding of how the public perceives UWS. UWS are not the same as other workspaces, and thus specia