김은선 교수
Eunseon Kim
서울대학교 · 의학
연구실 소개
김은선 교수의 연구실은 대장내시경 치료(ESD) 중 합병증 예측 요인, 만성 폐질환 환자의 폐부전 위험 평가, 고산소요법의 호흡기 질환 치료 효과, 비만 관련 대사질환의 분자 기전 규명, 그리고 약물 유도 신손상 완화 메커니즘 등 다양한 내과적 질환의 기전과 치료 전략을 연구하고 있습니다. 특히, adipose tissue 및 adipocyte의 단백질체 분석을 통한 비만 관련 대사질환의 새로운 치료 타겟 탐색에 초점을 맞추고 있으며, Behcet’s disease와 같은 희귀 자가면역질환의 임상 양상과 병태생리학적 기전에 대한 심층적 분석도 수행하고 있습니다. 이 연구들은 임상적 실천과 기초 생물학의 다리를 놓는 데 기여하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Tumor size and fibrosis are important factors related to complications during colorectal ESD. Younger age and development of abdominal pain can predict the hospital course in patients with perforation after ESD.
Even in patients with early-stage COPD, the prevalence of PPCs is higher than in patients with NSCLC with normal spirometry. However, this rate is not different between group A and group B patients with COPD. In accordance with this, scores based on symptoms or QoL are not predictors of risk of PPCs in patients with early-stage COPD.
HFNC oxygen therapy with sufficient FiO<sub>2</sub> to maintain a normal partial pressure of arterial oxygen (PaO<sub>2</sub>) significantly reduced PaCO<sub>2</sub> in acute respiratory failure with hypercapnia.
Obesity is a chronic disease that is associated with significantly increased levels of risk of a number of metabolic disorders. Despite these enhanced health risks, the worldwide prevalence of obesity has increased dramatically over the past few decades. Obesity is caused by the accumulation of an abnormal amount of body fat in adipose tissue, which is composed mostly of adipocytes. Thus, a deeper understanding of the regulation mechanism of adipose tissue and/or adipocytes can provide a clue fo
We demonstrated that DP extracts decreased cisplatin-induced renal toxicity, indicating its potential to ameliorate drug-associated acute kidney damage.
Behcet's disease is a multi-systemic vasculitis and characterized by systemic organ involvement. Although the gastrointestinal and systemic features of Behcet's disease and inflammatory bowel disease overlap to a considerable extent, they are generally viewed as two distinct diseases. A 39-yr-old female was diagnosed as having Behcet's disease. She was admitted to our hospital because of oral and genital ulcer, lower abdominal pain, and frequent diarrhea. Colonoscopy showed diffuse involvement o
Stroke is one of the commonest causes of death with limited treatment options. L-Carnosine has shown great promise as a neuroprotective agent in experimental stroke, but translation to the clinic is impeded by the large doses needed. We developed and evaluated the therapeutic potential of a novel delivery vehicle which encapsulated carnosine in lipoprotein receptor related protein-1 (LRP-1)-targeted functionalized polymersomes in experimental ischemic stroke. We found that following ischemic str
This study reviews the recent progress of explainable artificial intelligence for the early diagnosis of gastrointestinal disease (GID). The source of data was eight original studies in PubMed. The search terms were "gastrointestinal" (title) together with "random forest" or "explainable artificial intelligence" (abstract). The eligibility criteria were the dependent variable of GID or a strongly associated disease, the intervention(s) of artificial intelligence, the outcome(s) of accuracy and/o
Terlipressin-induced hyponatremia occurred frequently, especially in young patients with good liver function and higher Na level. Caution is required when administering terlipressin to patients with low body mass index.
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