이해원 교수
Hae Won Lee
서울대학교 · 의학
연구실 소개
이 교수의 연구실은 간암 환자에게서 생존율을 높이기 위한 보다 정교한 이식 기준 설정과 함께, 이식 후 재발을 줄이기 위한 생물학적 특성 분석에 중점을 두고 있습니다. 특히 막대한 종양 부위나 혈관 침범이 있는 말기 간세포암이 있는 환자들에 대해서도 간이식으로 치료 가능성을 모색하며, 생존율 향상과 합병증 관리에 대한 종합적 접근을 연구하고 있습니다. 또한 비장기 기증자 이식과 같은 특수한 이식 환경에서의 기준 확장과 환자 맞춤형 치료 전략 수립에도 기여하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15HR was significantly superior to RFA in terms of disease-free survival; however, the overall survival was excellent in both groups.
Intrahepatic biliary stricture (IHBS) after liver transplantation (LT) may develop in patients with hepatic artery thrombosis, chronic rejection, or ABO incompatibility, as well as in patients with prolonged warm ischemia in non-heart-beating donor (NHBD) LT. However, the clinical course and methods of management have not been well defined for IHBSs to date. Thus, the purpose of this study was to provide a classification of post-LT IHBS and to investigate patient prognosis. Forty-four patients w
Although far advanced hepatocellular carcinoma (HCC) is generally considered a contraindication for liver transplantation (LT), biologically favorable tumors among them could show acceptable results. However, it is still unclear which tumors can be treated with LT. Data were collected on adult patients who underwent LT for HCC beyond the Milan criteria in 8 Korean LT centers between January 2000 and June 2013. Far advanced HCC was defined as HCC with the largest tumor ≥ 10 cm, 10 or more tumor n
There has been ongoing debate that the Milan criteria may be too strict that a significant number of patients who could benefit from liver transplantation (LT) might have been excluded. Based on this idea, various studies have been conducted to further expand the Milan criteria and give more HCC patients a chance of cure. In deceased donor LT (DDLT) setting, expansion of the criteria is relatively tempered because the results of LT for HCC should be comparable to those of patients with non-malig
The overall chance of survival, and recipient/donor preferences as well as the risk of recurrence are considered in the LDLT setting. Therefore, the selection criteria for liver transplantation for HCC could benefit from expansion for LDLT.
The Milan criteria are still considered the gold standard for patient selection criteria for liver transplantation in patients with hepatocellular carcinoma. However, those criteria may be too strict and thus exclude a significant number of patients who could benefit from liver transplantation. Based on this notion, many expanded selection criteria have been suggested. In Asian countries, where there is a serious shortage of deceased donor organs, living donor liver transplantation accounts for
Although liver transplantation (LT) is the only effective treatment option for hepatopulmonary syndrome (HPS), the post-LT morbidity and mortality have been high for patients with severe HPS. We performed post-LT embolotherapy in a 10-year-old boy who had severe type I HPS preoperatively, but he failed to recover early from his hypoxemic symptoms after an LT. Multiple embolizations were then successfully performed on the major branches that formed the abnormal vascular structures. After the embo
We report the first identification of a spawning ground of the blackfin flounder Glyptocephlaus stelleri near the Wangdol-cho sea mountains, located in the southern East Sea. Eggs and larval fish of G. stelleri were collected during April and June, 2014, when an abundance of eggs was found in the southern area of Wangdol-cho. Our findings suggest that G. stelleri prefers to spawn in the vicinity of the off-shore sea mountains, where the temperature is between 10 and <TEX>$12^{\circ}C$</TEX> and
We investigated the major trends in health aid financing in the Democratic People’s Republic of Korea (DPRK) by identifying the primary donor organizations and examining several data sources to track overall health aid trends. We collected gross disbursements from bilateral donor countries and international organizations toward the DPRK according to specific health sectors by using the Organization for Economic Cooperation and Development creditor reporting system database and the United Nations
With the recent development of image processing and deep learning technology, research and application in the fields of ultra-high-resolution image generation and cartoon-style conversion are expanding further.Among the ultra-resolution image generation models, the CartoonGAN model is specialized in generating cartoon-style images, but there are limitations in terms of resolution improvement.This study proposes an innovative method of additionally applying a Super-Resolution Convolutional Neural
Hae Won Lee, M.D., Kwang-Woong Lee, M.D., Bong-Wan Kim, M.D., Gi-Won Song, M.D., Young Seok Han, M.D., Choon Hyuck David Kwon, M.D., Seong Hoon Kim, M.D., Gi Hong Choi, M.D. and Jong Young Choi, M.D.. J Korean Soc Transplant 2012;26:269-76. https://doi.org/10.4285/jkstn.2012.26.4.269
Our findings indicate that postoperative combination prophylaxis is effective and that preoperative lamivudine therapy is unlikely to be obligatory despite a positive preoperative serum HBV DNA status.
Although laparoscopic donor right hepatectomy (LDRH) is increasingly performed in adult living donor liver transplantation, most experiences have been reported from a limited number of major transplant centers. This is because LDRH requires high-level surgical skills and a guarantee of donor safety. Thus, despite its many advantages, this operation program should be performed with caution, especially in less experienced centers. Various surgical techniques and the know-how have been introduced b
멸치의 연령 및 성장특성을 분석하기 위해 2004년에 남해연안에서 채집된 개체들의 이석 506개를 분석하였으며, 윤문에 의해 결정된 연령과 채집시기를 기준으로 멸치의 월령을 추정하였다. 월령별 가랑이 체장을 이용하여 구한 성장 매개변수인 이론적 최대 체장은 132.9 mm, 성장계수는 0.1079/month였으며 체장이 0일 때의 이론적 연령은 1.0262월이었다. 이들 매개변수로 von Bertalanffy 체장성장식을 나타내면, L<sub>t</sub>=132.9(1- e<sup>-0.1079 (t-1.0262)</sup>)였다. 연륜과 채집시기를 통해 설정한 월령기준의 성장 매개변수 추정은 우리나라 멸치의 성장특성을 파악하기에 적절한 것으로 판단되었다.
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