이학민 교수
Hark Min Lee
서울대학교 · 의학
연구실 소개
이학민 교수의 연구실은 신장세포암과 전립선암의 수술적 치료 및 예후 예측에 중점을 두고 있으며, 특히 수술 전 생체정보 지표와 영상 진단 기술의 임상적 의미를 규명하고자 합니다. 3D 신장 해부도 모델을 활용한 수술 계획 및 의학 교육의 융합적 응용도 활발히 진행 중이며, 로봇 및 복강경 수술의 우수성과 허혈 시간이 신기능에 미치는 영향에 대한 정밀 분석도 지속되고 있습니다. 특히, 암의 임상적 단계와 조직병리학적 결과 간 괴리(업스테이징)가 생존에 미치는 영향을 분석함으로써 개인화된 치료 전략 수립에 기여하고자 합니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15An elevated AST/ALT ratio was significantly associated with worse postoperative survival in patients surgically treated for localized clear-cell RCC. Further prospective studies are needed to understand the prognostic value of preoperative AST/ALT ratio.
The personalized 3D renal model was revealed to significantly enhance the understanding of correct renal anatomy in patients with renal tumors in both urologist and student groups. These models can be useful for establishing the perioperative planning and also education program for medical students.
The laparoscopic and robotic approaches yielded better perioperative outcomes, such as less intraoperative bleeding, shorter hospital stays, less analgesic usage, and non-inferior oncological outcomes, compared with the open approach. Further prospective studies are needed to compare these surgical techniques.
Patients up-staged from clinical stage T1 to pathologic stage T3a RCC showed shorter survival outcomes than those without upstaging. However, partial nephrectomy, compared with radical nephrectomy, showed comparable outcomes in patients who were up-staged.
Prolonged WIT was not associated with increased incidence of CKD or MRFD after PN.
DWI detects tumors in PZ of prostate more accurately than those in TZ. Such accuracy of DWI was shown to be more evident with higher DWI grade. Meanwhile, a negative DWI did not guarantee absence of high grade PCa.
Poor glycemic control was significantly associated with BCR after RP. Meanwhile, metformin use was not associated with biochemical outcome after RP. Further investigation would be needed to identify exact mechanism underlying the impact of glycemic control on PCa treatment outcome.
Diabetes mellitus is an independent predictor of cancer specific and overall survival in patients who undergo surgery for renal cell carcinoma. Also, in patients with diabetes mellitus poor glycemic control is associated with a higher risk of progression.
There was a decrease in detrusor wall thickness after transurethral prostatectomy. The large prostate group and the high Abrams-Griffiths number group showed a significant decrease in detrusor wall thickness after surgery.
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