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이희선 교수

Hee Sun Lee

서울대학교 · 의학

연구실 소개

이희선 교수의 연구실은 대사질환, 특히 비만과 인슐린 저항성과 관련된 대사 변화에 영향을 미치는 천연소재의 기전을 규명하는 데 초점을 맞추고 있습니다. 주로 치료적 응용이 가능한 천연 유래 물질인 초록조류 클로렐라의 대사 조절 효과를 실험동물 모델을 통해 분석하며, 지질 대사 및 혈액포도당 조절 기전에 대한 기초 연구를 진행하고 있습니다. 또한, 심혈관계 질환과 만성 신장질환 등 대사 이상이 연관된 만성질환의 장기적 영향에 대해서도 인구기반 코hort 연구를 통해 종합적 분석을 수행하고 있습니다.

클로렐라대사질환지질대사인슐린저항성심혈관계질환

연구 현황

논문 수
132
총 인용 수
2,479
최근 5년 논문
63
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
63총합
2022
2023
2024
2025
2026
5개년 연도별 피인용 수
547총합
20222023202420252026

주요 논문

15
1
논문|인용수 122·2017
Noncontrast Myocardial T1 Mapping by Cardiac Magnetic Resonance Predicts Outcome in Patients With Aortic Stenosis
Heesun Lee, Jun‐Bean Park, Yeonyee E. Yoon, Eun‐Ah Park, Hyung‐Kwan Kim, Whal Lee, Yong‐Jin Kim, Goo‐Yeong Cho, Dae‐Won Sohn, Andreas Greiser, Seung‐Pyo Lee
SJR Q1FWCI 11.6JACC. Cardiovascular imaging
Radiology, Nuclear Medicine and ImagingMedicine
2
논문|인용수 55·2020
Association of four lipid components with mortality, myocardial infarction, and stroke in statin-naïve young adults: A nationwide cohort study
Heesun Lee, Jun‐Bean Park, In‐Chang Hwang, Yeonyee E. Yoon, Hyo Eun Park, Su‐Yeon Choi, Yong-Jin Kim, Goo-Yeong Cho, Kyungdo Han, Hyung‐Kwan Kim
SJR Q1FWCI 6.5European Journal of Preventive Cardiology

For statin-naïve young adults, the risk of clinical events was proportional to lipid levels, positively with TC and triglycerides, negatively with HDL-C, and J-shaped with LDL-C. Triglycerides had an independent and the strongest association with the clinical events. Screening and intervention for abnormal lipid levels, particularly triglycerides, from an early age might be of clinical value.

SurgeryMedicine
3
논문|인용수 29·2023
Comparative cardiovascular outcomes in type 2 diabetes patients taking dapagliflozin versus empagliflozin: a nationwide population-based cohort study
Jaehyun Lim, You-Jung Choi, Bong Sung Kim, Tae‐Min Rhee, Hyun-Jung Lee, Kyungdo Han, Jun‐Bean Park, Jin Oh Na, Yong Jin Kim, Heesun Lee, Hyung‐Kwan Kim
SJR Q1FWCI 5.8Cardiovascular DiabetologyOA

This large-scale nationwide population-based real-world cohort study revealed no significant difference in composite cardiovascular outcomes between new users of dapagliflozin and empagliflozin. However, dapagliflozin might be associated with lower risks of hospitalization or death due to HF and cardiovascular death than empagliflozin in Asian patients with type 2 diabetes mellitus.

Endocrinology, Diabetes and MetabolismMedicine
4
논문|인용수 29·2019
Risk of end-stage renal disease in patients with hypertrophic cardiomyopathy: A nationwide population-based cohort study
Heesun Lee, Kyungdo Han, Jun‐Bean Park, In‐Chang Hwang, Yeonyee E. Yoon, Hyo Eun Park, Su‐Yeon Choi, Yong-Jin Kim, Goo-Yeong Cho, Hyung‐Kwan Kim, Steve R. Ommen
SJR Q1FWCI 2.6Scientific ReportsOA

Although hypertrophic cardiomyopathy (HCM), the most common inherited cardiomyopathy, has mortality rate as low as general population, previous studies have focused on identifying high-risk of sudden cardiac death. Thus, long-term systemic impact of HCM is still unclear. We sought to investigate the association between HCM and end-stage renal disease (ESRD). This was a nationwide population-based cohort study using the National Health Insurance Service database. We investigated incident ESRD dur

Cardiology and Cardiovascular MedicineMedicine
5
논문|인용수 22·2020
Clinical Significance of Body Fat Distribution in Coronary Artery Calcification Progression in Korean Population
Heesun Lee, Hyo Eun Park, Ji Won Yoon, Su‐Yeon Choi
SJR Q1FWCI 1.0Diabetes & Metabolism JournalOA

Predominant VAT area on CT is the strongest predictor of CAC progression regardless of BMI or WC in apparently healthy Korean population. Assessment of body fat distribution may be helpful to identify subjects at higher risk.

Cardiology and Cardiovascular MedicineMedicine
6
논문|인용수 21·2021
Cumulative exposure amount of PM2.5 in the ambient air is associated with coronary atherosclerosis - Serial coronary CT angiography study
Heesun Lee, Jung Hye Kim, Minkwan Kim, Hyo Eun Park, Su‐Yeon Choi, Hye Kyung Kim, Byoung Kwon Lee, Jin‐Young Min, Kyoung‐Bok Min, Shinae Kang, Seung‐Pyo Lee
SJR Q1FWCI 1.3Journal of cardiovascular computed tomographyOA
Health, Toxicology and MutagenesisEnvironmental Science
7
논문|인용수 20·2024
Association between cumulative metabolic risk exposure and cardiovascular disease: a nationwide cohort of over 3.6 million young adults
Heesun Lee, Tae‐Min Rhee, Hyo Eun Park, Kyungdo Han, Su‐Yeon Choi
SJR Q1FWCI 7.2European Journal of Preventive CardiologyOA

The risk of CVD increased in an exposure-dependent manner among young adults. Efforts to optimize the cardiometabolic profile, particularly BP, even after the establishment of MetS, might help promote long-term cardiovascular prognosis.

Endocrinology, Diabetes and MetabolismMedicine
8
논문|인용수 20·2017
Impact of a Telehealth Program With Voice Recognition Technology in Patients With Chronic Heart Failure: Feasibility Study
Heesun Lee, Jun‐Bean Park, Sae Won Choi, Yeonyee E. Yoon, Hyo Eun Park, Sang Eun Lee, Seung‐Pyo Lee, Hyung‐Kwan Kim, Hyun‐Jai Cho, Su‐Yeon Choi, Hae‐Young Lee, Jonghyeon Choi
SJR Q1FWCI 0.9JMIR mhealth and uhealthOA

Short-term application of ICT-based telehealth program with voice recognition technology showed the potential to improve uNa values and MLHFQ scores in HF patients, suggesting that better control of sodium intake and greater quality of life can be achieved by this program.

Cardiology and Cardiovascular MedicineMedicine
9
논문|인용수 19·2016
A randomized clinical trial comparing long-term clopidogrel vs aspirin monotherapy beyond dual antiplatelet therapy after drug-eluting coronary stent implantation: Design and rationale of the Harmonizing Optimal Strategy for Treatment of coronary artery stenosis-Extended Antiplatelet Monotherapy (HOST-EXAM) trial
Heesun Lee, Bon‐Kwon Koo, Kyung Woo Park, Eun‐Seok Shin, Sang Wook Lim, Seung‐Woon Rha, Jang‐Whan Bae, Dong Woon Jeon, Seok-Kyu Oh, Seung‐Ho Hur, Bum-Su Kim, Jung‐Hee Lee
SJR Q1FWCI 0.3American Heart JournalOA
SurgeryMedicine
10
논문|인용수 13·2017
Hyponatraemia and its prognosis in acute heart failure is related to right ventricular dysfunction
Heesun Lee, Sang Eun Lee, Chan Soon Park, Jin Joo Park, Ga Yeon Lee, Min‐Seok Kim, Jin‐Oh Choi, Hyun‐Jai Cho, Hae‐Young Lee, Dong‐Ju Choi, Eun‐Seok Jeon, Jae‐Joong Kim
SJR Q1FWCI 0.7Heart

Objectives Hyponatraemia is a well-known predictor of clinical outcomes in heart failure (HF). However, the mechanism remains poorly understood. Previous reports suggest that hyponatraemia is related to right HF. We sought to evaluate the association between right ventricular (RV) dysfunction and hyponatraemia, and the impact of this relationship on the prognosis of patients with acute heart failure (AHF). Methods This is a nested case–control study of the Korean Acute Heart Failure registry. Am

Cardiology and Cardiovascular MedicineMedicine
11
논문|인용수 11·2016
The Incremental Prognostic Value of Cardiac Computed Tomography in Comparison with Single-Photon Emission Computed Tomography in Patients with Suspected Coronary Artery Disease
Heesun Lee, Yeonyee E. Yoon, Jun‐Bean Park, Hack‐Lyoung Kim, Hyo Eun Park, Seung‐Pyo Lee, Hyung‐Kwan Kim, Su‐Yeon Choi, Yong‐Jin Kim, Goo‐Yeong Cho, Joo‐Hee Zo, Dae-Won Sohn
SJR Q1FWCI 2.0PLoS ONEOA

Comprehensive CCTA evaluation of coronary atherosclerosis provides independent and incremental prognostic value in relation to SPECT evaluation of myocardial ischemia. Specifically, segmentally-analyzed plaque composition with CCTA provides further risk stratification in addition to CACS and DS.

Radiology, Nuclear Medicine and ImagingMedicine
12
논문|인용수 11·2024
Impact of clonal haematopoiesis on atherosclerotic cardiovascular disease according to low-density lipoprotein cholesterol levels in general population
Heesun Lee, Han Song, Su‐Yeon Choi, Youngil Koh, Gangpyo Ryu, Hyo Eun Park, Ji Won Yoon, Min Joo Kim, Soie Chung, Jung Ho Bae, Seung Ho Choi, Bon‐Kwon Koo
SJR Q1FWCI 4.0European Journal of Preventive CardiologyOA

The presence of CHIP was significantly associated with the risk of ASCVD, promoting the early stage of atherosclerosis through synergy with high LDL cholesterol in the general population.

Cardiology and Cardiovascular MedicineMedicine
13
리뷰|인용수 10·2025
The Close Link Between Obesity and Cardiovascular Disease
Heesun Lee, Tae‐Min Rhee, Ji Min Choi, Su‐Yeon Choi, Dong Wook Kim
SJR Q1FWCI 10.5Endocrinology and Metabolism Clinics of North America
PhysiologyMedicine
14
논문|인용수 9·2015
Presence and extent of coronary calcified plaque evaluated by coronary computed tomographic angiography are independent predictors of ischemic stroke in patients with suspected coronary artery disease
Heesun Lee, Yeonyee E. Yoon, Yong‐Jin Kim, Hack‐Lyoung Kim, Seung‐Pyo Lee, Hyung‐Kwan Kim, Goo‐Yeong Cho, Joo‐Hee Zo, Dae‐Won Sohn
FWCI 1.6International journal of cardiac imaging
Radiology, Nuclear Medicine and ImagingMedicine
15
논문|인용수 9·2012
The Relationships between Mother's Psychological Control and Self-Directed Learning Ability in Elementary School Students: Focusing on the Mediating Effects of Self-Determined Motivation
Heesun Lee, Yongae Kwon
FWCI 3.9Journal of the Korean Home Economics AssociationOA

. 21 . , .

Sociology and Political ScienceSocial Sciences

대표 연구 분야

Cardiology and Cardiovascular MedicineSurgeryRadiology, Nuclear Medicine and ImagingEpidemiologyEndocrinology, Diabetes and MetabolismPhysiology

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