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권혁준 교수

Hyuk-Joon Kwon

서울대학교 · 의학

연구실 소개

권혁준 교수의 연구실은 인플루엔자 바이러스의 유전자 기반 변형과 병원성 조절을 핵심으로 하며, 특히 가금류에 기생하는 아형 인플루엔자 A 바이러스 및 병원성 대장균의 항생제 내성 메커니즘을 분석하고 있습니다. 또한 라이소좀 저장질환인 GM1 갈락토시드증의 뇌영상학적 특성과 병태생리학적 진행을 규명하는 데에도 기여하고 있습니다. 연구는 바이러스의 숙주 적응 메커니즘과 병원성 조절, 항생제 내성 유전자 전파를 중심으로 진행되고 있습니다.

바이러스 유전자 변형항생제 내성병원성 조절뇌영상학적 분석병원성 대장균

연구 현황

논문 수
58
총 인용 수
286
최근 5년 논문
35
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
35총합
2015
2017
2018
2025
2026
5개년 연도별 피인용 수
11총합
20152017201820252026

주요 논문

15
1
논문|인용수 58·2012
Pathotyping avian pathogenic<i>Escherichia coli</i>strains in Korea
Yong-Wun Jeong, Tae-Eun Kim, Jae‐Hong Kim, Hyuk-Joon Kwon
SJR Q2FWCI 2.0Journal of Veterinary ScienceOA

To examine the genetic background of avian pathogenic Escherichia coli (APEC) that affects virulence of this microorganism, we characterized the virulence genes of 101 APEC strains isolated from infected chickens between 1985 ˜ 2005. Serotypes were determined with available anti-sera and median lethal doses were determined in subcutaneously inoculated chicks. The virulence genes we tested included ones encoding type 1 fimbriae (fimC), iron uptake-related (iroN, irp2, iucD, and fyuA), toxins (lt,

EndocrinologyBiochemistry, Genetics and Molecular Biology
2
논문|인용수 49·1999
Establishment and characterization of 12 human colorectal-carcinoma cell lines
Jae-Hwan Oh, Ja‐Lok Ku, Kyong-Ah Yoon, Hyuk-Joon Kwon, Woo Ho Kim, Hyun-Sook Park, Kiat Seng Yeo, Sang-Yong Song, June‐Key Chung, Jae-Gahb Park
SJR Q1FWCI 0.9International Journal of Cancer

In this article, we describe the characteristics of 12 human colorectal-carcinoma cell lines established from 6 primary tumors and 6 metastatic sites of 11 Korean colorectal-carcinoma patients, including the morphology in vivo and in vitro and mutations of K-ras2, p15, p16, p53, APC, beta-catenin, hMLH1 and hMSH2 genes in vitro. No lines were contaminated with Mycoplasma or bacteria. All lines were proven to be unique by DNA-fingerprinting analysis. All lines expressed the surface carcino-embryo

Pathology and Forensic MedicineMedicine
3
논문|인용수 40·2010
An Anti-influenza Component of the Bark of Alnus japonica
Nguyen Huu Tung, 권혁준, 김재홍, 라정찬, 김정아, 김영호

This study to identify anti-influenza components of the bark of Alnus japonica resulted in the isolation of four lupane-type triterpenes (1-4) and one steroid (5). Their structures were characterized on the basis of physicochemical properties, NMR evidence, and ESI-MS data compared with reported data in the literature. Betulinic aldehyde (3) exhibited a particularly strong anti-influenza effect against KBNP-0028 relative to a positive control.

4
논문|인용수 29·1999
Germline mutations of the APC gene in Korean familial adenomatous polyposis patients
Yong‐Jin Won, Kyu Joo Park, Hyuk-Joon Kwon, J.-H. Lee, Jung‐Hyun Kim, Young Jin Kim, Soo Han Chun, Hye-Jung Han, J.-G. Park
SJR Q2FWCI 0.4Journal of Human GeneticsOA
Pathology and Forensic MedicineMedicine
5
논문|인용수 29·2013
Genetic Diversity of Spike, 3a, 3b and E Genes of Infectious Bronchitis Viruses and Emergence of New Recombinants in Korea
Mei-Lan Mo, Seung-Min Hong, Hyuk-Joon Kwon, Il Hwan Kim, Chang‐Seon Song, Jae‐Hong Kim
SJR Q1FWCI 3.2VirusesOA

The nucleotide sequences of a region including S1, S2, 3a, 3b and E genes of twenty-seven infectious bronchitis virus (IBV) isolates in Korea between 1990-2011 were determined and phylogenetic and computational recombination analyses were conducted. The sizes of coding regions of some genes varied among IBV isolates due to deletion or insertion of nucleotides; the nucleotide similarities of S1, S2, 3a, 3b and E genes among the 27 isolates were 75.9%-100.0%, 85%-100.0%, 64.0%-100.0%, 60.4%-100.0%

Animal Science and ZoologyAgricultural and Biological Sciences
6
논문|인용수 17·2012
Molecular Serotyping of Salmonella enterica by Complete rpoB Gene Sequencing
성원진, 권혁준, 김태은, 이덕용, 박미선, 김재홍

Serotyping has been the gold standard for identifying Salmonella, but it requires large amounts of standard antisera. Multilocus sequence typing (MLST) has been applied to identify Salmonella serovars, but the recombination of 4–7 housekeeping genes and multiple analytic steps diminish its applicability. In the present study, we determined the complete sequences of the RNA polymerase beta subunit gene (rpoB) and 7 housekeeping genes (aroC, dnaN, hemD, hisD, purE, sucA, and thrA) for 76 strains o

7
논문|인용수 16·2001
Application of nucleotide sequence of RNA polymerase β-subunit gene (rpoB) to molecular differentiation of serovars of Salmonella enterica subsp. enterica
Hyuk-Joon Kwon, Kyoung-Yoon Park, Sun-Joong Kim, Han Sang Yoo
SJR Q1FWCI 0.5Veterinary Microbiology
Food ScienceAgricultural and Biological Sciences
9
논문|인용수 5·2012
독일 축구영화 <베른의 기적>과 집단적 정체성의 문제
권혁준

In dieser Arbeit wird versucht, Sönke Wortmanns erfolgreichen Fußballfilm Das Wunder von Bern (2003) aus der Perspektive der kollektiven Identität zu analysieren. In dem Film wird die Geschichte von Deutschlands unerwartetem Sieg bei der Fußball-Weltmeisterschaft 1954 in Bern erzählt. Das als ‘Wunder von Bern’ genannte Ereignis wird oft als ‘echte Geburtsstunde’ Deutschlands gewertet,weil die Deutschen durch diesen Sieg zum ersten Mal nach dem Krieg wieder zu großem Selbstbewusstsein gelangten.

10
논문|인용수 5·2025
Rapid and specific on-site H5Nx avian influenza diagnosis via RPA and PAM-independent CRISPR-Cas12a assay combined with anti-NP antibody-based viral RNA purification
Jin-Ha Song, Seung-Eun Son, H. K. Kim, Seung-Ji Kim, Se-Hee An, Chung-Young Lee, Hyuk-Joon Kwon, Kang-Seuk Choi
SJR Q1FWCI 4.0Frontiers in Veterinary ScienceOA

Rapid and accurate detection of H5Nx avian influenza viruses is critical for effective surveillance and control measures. Currently, RT-qPCR with spin column RNA extraction is the gold standard for HPAIV surveillance, but its long reaction time and need for specialized equipment limit its effectiveness for rapid response. In this study, we introduce a centrifuge-free, rapid detection method for on-site detection of H5Nx viruses that combines magnetic bead-based ribonucleoprotein (RNP) purificati

Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
논문|인용수 4·2007
카프카의 인류타락 신화 수용과 형상화 - 작품 『선고』를 중심으로
권혁준

Der biblische Sündenfallmythos besitzt sowohl in Kafkas Denken als auch in seinem Werk einen hohen Stellenwert. In dieser Arbeit habe ich versucht darzustellen, wie Kafka in seiner Erzählung Das Urteil die Gestaltung dieses Mythos unternimmt. Für die Annahme, dass Kafkas Gedankenwelt von dem biblischen Sündenfallmythos stark geprägt ist, spricht zunächst seine intensive Beschäftigung mit diesem Mythos, vor allem aus den Jahren 1917 und 1918. Wichtige Punke in Kafkas Exegese des Sündenfallmythos

12
논문|인용수 4·2010
사회적 금기의 예술적 형상화 -바그너의 음악극 『니벨룽의 반지』와 영화 『올드보이』에서의 ‘근친상간’ 모티프 연구
권혁준

In dieser Arbeit wird versucht, das Inzestmotiv in Wagners Ring des Nibelungen (1851-1874) und in dem koreanischen Film Oldboy (2003) vergleichend zu untersuchen, um eine Art und Weise der Darstellung des sozialen Tabus in der modernen Kunst festzustellen. Der Inzest ist eines des wenigen universellen Tabus der Menschheit. In der deutschen Literatur wird der vollzogene Inzest zwischen Verwandten meist hart bestraft. Dabei geht es um gesellschaftliche Praxis und nicht um naturrechtliche Prinzipie

13
논문|인용수 4·2017
젖소 유방염에서 16S rRNA 파이로시퀀싱을 이용한 우유 내 마이크로바이옴의 동정과 난백의 항균효과
김단일, 김은경, 성원진, 노영혜, 고대성, 김남형, 김재홍, 권혁준
대한수의학회지

Bovine mastitis is an important microbial disease in the dairy industry. We investigated the frequencies of bacterial pathogens in 62 farms and pathogen antibiotic resistance from mastitis samples (n = 748). We tested the antimicrobial activity of chicken and duck egg white and lysozyme purified from chicken egg white. Moreover, we compared the microbiomes of normal and mastitic raw milk obtained by 16S rRNA gene pyrosequencing and culture methods. The results showed that the frequencies of Gram

14
논문|인용수 4·2011
‘위기’의 미학: 세기전환기 언어성찰과 생산적 글쓰기(1) - 니체와 마우트너의 언어비판을 중심으로
권혁준

In dieser Arbeit wird versucht, die Sprachkritik um die Jahrhundertwende anhand der Texte von Nietzsche und Mauthner zu analysieren, um ihre Bedeutung für die literarische Moderne auszuloten. Bei der Darstellung der zentralen Kritikpunkte Nietzsches sind zwischen zwei Papadigmata, Wortebene und syntaktischer Ebene, zu unterscheiden. Auf der Wortebene zeigt sich, dass es sich bei Wörtern ursprünglich um Metaphern handelt, also um Übertragung von unvollkommenen, auf Ähnlichkeiten beruhenden Abbild

15
논문|인용수 3·2012
테크노포비아와 테크노필리아 사이에서 - 현대 ‘기술매체’와 카프카의 서사텍스트
권혁준

In der vorliegenden Arbeit wird versucht, Kafkas Umgang mit dem grundlegenden Wandel technischer Speichermedien um 1900, die mit einer Entprivilegierung von Schriftsprachlichkeit einhergeht, anhand seiner Texte zu beleuchten. Die Veränderung jener Zeit betreffen nicht nur Kulturproduktion,sondern auch die ganze Lebens- und Erfahrungswelt der Menschen. Mechanisierung und Bürokratisierung der Gesellschaft stehen im Zeichen neuer technischer Übertragungsmöglichkeiten. Die Lebenszeit Kafkas und somi

대표 연구 분야

EpidemiologyPathology and Forensic MedicineMolecular BiologyEndocrinologyAnimal Science and ZoologyFood Science

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