이재현 교수

Cancer-cell-targeted gene silencing was observed with a magnetic-nanoparticle platform (MEIO, magnetism-engineered iron oxide) on which a fluorescent dye, siRNA, and a RGD-peptide targeting moiety were attached (see picture). The different functionalities enable the macroscopic (magnetic resonance) and microscopic (fluorescence) imaging of target cells. This system may be suitable for concurrent diagnostic and therapeutic applications.

Working together: A “core–satellite” hybrid nanoparticle probe provides highly improved fluorescence and magnetic resonance (MR) imaging capabilities through synergistic enhancement of its respective components. These hybrid nanoprobes can be used for dual-modal fluorescence and MR imaging of neuroblastoma with expressed polysialic acids. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z603052_s.pdf or from the author. Please no

On-demand drug release: Magnetothermally responsive drug-encapsulated supramolecular nanoparticles for on-demand drug release in vivo have been developed. The remote application of an alternative magnetic field heats the magnetic particles that effectively trigger the release of the drug. An acute drug concentration can be delivered to the tumor in vivo, resulting in an improved therapeutic outcome.

Semiconductor nanowire (NW) devices that can address intracellular electrophysiological events with high sensitivity and spatial resolution are emerging as key tools in nanobioelectronics. Intracellular delivery of NWs without compromising cellular integrity and metabolic activity has, however, proven difficult without external mechanical forces or electrical pulses. Here, we introduce a biomimetic approach in which a cell penetrating peptide, the trans-activating transcriptional activator (TAT)

We introduce cubic magnetic nanoparticles as an effective tool for precise and ultrafast control of mechanosensitive cells. The temporal resolution of our system is ∼1000 times faster than previously used magnetic switches and is comparable to the current state-of-the-art optogenetic tools. The use of a magnetism-gated switch reported here can address the key challenges of studying mechanotransduction in biological systems. The cube-shaped magnetic nanoparticles are designed to bind to component

본 논문은 최근 미디어 수렴이 가속화되는 상황에서 이용자 수준에서 이루어지는 다양한 미디어 사이의 연계를 설명할 수 있는 "다중 미디어의 논리"를 개발할 필요가 있다는 전제 하에, 여러 미디어 플랫폼을 넘나들며 여러 플랫폼의 콘텐츠를 동시적으로, 비동시적으로 관여하는 독특한 미디어 이용행위를 "멀티플랫포밍(multiplatforming)"으로 개념화하고 이 과정을 이론화하였다. 먼저 멀티플랫포밍 행위를 미디어 축과 시간 축을 중심으로 이론화하였는데, 전자는 "미디어 매트릭스의 구성"으로, 후자는 "시간의 심화"로 개념화하였다. 둘째, 멀티플랫포밍에 대한 이론화를 토대로 멀티플랫포밍 속에서 이루어지는 모바일 미디어 이용 행태를 경험적 자료를 통해 설명하였다. 셋째, 모바일 미디어를 중심으로 한 멀티플랫포밍에 대한 분석을 토대로 모바일 미디어의 시간성과 콘텐츠의 특성을 새롭게 규정하였다. 마지막으로 멀티플랫포밍의 모바일 콘텐츠 편성에 대한 함의를 이론적, 실무적 차원에서 논의하였다.

Teamarbeit: Eine „Kern-Satelliten“-Hybridnanopartikel-Sonde ermöglicht dank der synergistischen Verstärkung ihrer Komponenten ein erheblich verbessertes Fluoreszenz- und Magnetresonanz(MR)-Imaging. Diese Hybridnanosonden können für das dual-modale Fluoreszenz- und MR-Imaging von Neuroblastoma mit exprimierten Polysialinsäuren genutzt werden. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2001/2006/z603052_s.pdf or from the author. Please

Research on whether the number or location of missing teeth affects the accuracy of intraoral scanners in partial edentulous patients is scarce. This study aimed to evaluate the precision of complete-arch scan data of various partial edentulous arches acquired by intraoral scanners. Five different maxillary models were scanned using Carestream CS3600 and Medit i500 scanners. The models employed here were control: Fully dentate; Case 1: Missing a right second premolar and a first molar; Case 2: M

Magnetic attraction: Artificial control of cell activities is achieved by nanoscale magneto-activated cellular signaling (N-MACS), in which magnetic nanoparticles are selectively linked to cell surface receptors and aggregated by an external magnetic field. Such mechanocellular activation induces downstream cell signaling and initiates tubulogenesis in the preangiogenesis stage of endothelial cells (see picture). Detailed facts of importance to specialist readers are published as ”Supporting Inf

Abstract Eine gezielte Genstummschaltung in Krebszellen gelang mit magnetischen Eisenoxid‐Nanopartikeln (MEIO), an denen ein Fluoreszenzfarbstoff, siRNA sowie ein RGD‐Peptid zur Erkennung von Krebszellen angebracht waren (siehe Bild). Die verschiedenen funktionellen Einheiten ermöglichen eine kombinierte makroskopische (Kernspin‐) und mikroskopische (Fluoreszenz‐)Tomographie der Zielzellen. Dieses System könnte sich für die parallele diagnostische und therapeutische Anwendung eignen. magnified i

Wirkstoff-Freisetzung auf Abruf: Thermomagnetisch responsive supramolekulare Nanopartikel mit einem eingekapselten Wirkstoff wurden für die In-Vivo-Wirkstoff-Freisetzung auf Abruf entwickelt. Durch ein magnetisches Feld werden die Partikel aufgeheizt, was die Freisetzung des Wirkstoffs einleitet. Eine plötzlich freigesetzte Wirkstoffkonzentration kann in vivo zu einem Tumor gelangen und verbessert somit das Therapieergebnis. As a service to our authors and readers, this journal provides supporti