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김재원 교수

Jae-Weon Kim

서울대학교 · 의학

연구실 소개

김재원 교수의 연구실은 주로 종양 생물학과 분자 의학 분야에서 활동하며, 암의 발병 기전과 치료 타겟을 규명하는 데 초점을 맞추고 있습니다. 특히 간세포암, 자궁경부암, 폐암 등 다양한 암 종양에서의 유전자 발현 변화, 염증 반응과 정서 장애의 연관성, 그리고 천연물질(예: 진세노사이드 Rg3)이 혈관신생을 억제하는 메커니즘을 연구하고 있습니다. 또한, 단백질 지ap 및 메틸화 프로파일을 기반으로 한 진단 및 예후 생물학적 마커 개발에도 기여하고 있습니다.

암 생물학유전자 메틸화혈관신생 억제천연물 항암생물학적 마커

연구 현황

논문 수
596
총 인용 수
30,495
최근 5년 논문
49
주요 분야
의학

연구 성과 추이

표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.

5개년 연도별 논문 게재 수
49총합
2022
2023
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2025
2026
5개년 연도별 피인용 수
1,415총합
20222023202420252026

주요 논문

15
1
논문|인용수 182·2010
Employee voice and organizational performance: Team versus representative influence
Jae‐Won Kim, John Paul MacDuffie, Frits K. Pil
SJR Q1FWCI 11.7Human Relations

This article explores the effects of team voice and worker representative voice, as well as their interaction, on labor productivity. We examine team voice in terms of team influence on key work-related issues and representative voice via the degree of worker representatives’ influence on multiple collective voice issues. We thus build on the European tradition of examining both direct and indirect voice and their implications for valued organizational outcomes. We find that neither type of voic

Safety ResearchSocial Sciences
2
논문|인용수 173·2005
Structural Basis for Endosomal Targeting by the Bro1 Domain
Jaewon Kim, Sujatha Sitaraman, Aitor Hierro, Bridgette M. Beach, Greg Odorizzi, James H. Hurley
SJR Q1FWCI 6.5Developmental CellOA
Cell BiologyBiochemistry, Genetics and Molecular Biology
3
리뷰|인용수 154·2012
Efficacy of neoadjuvant chemotherapy in patients with FIGO stage IB1 to IIA cervical cancer: An international collaborative meta-analysis
Hyun Suk Kim, Juan E. Sardi, Noriyuki Katsumata, Hee‐Sug Ryu, Joo-Hyun Nam, Hyun Hoon Chung, N.H. Park, Yong Sang Song, Nadereh Behtash, Toshiharu Kamura, Hongbing Cai, Jae‐Weon Kim
SJR Q1FWCI 7.4European Journal of Surgical Oncology
Obstetrics and GynecologyMedicine
4
논문|인용수 118·2002
Proteome analysis of human liver tumor tissue by two‐dimensional gel electrophoresis and matrixassisted laser desorption/ionization‐mass spectrometry for identification of disease‐related proteins
Jina Kim, Jina Kim, Soon H. Kim, Seung U. Lee, Geun‐Hyoung Ha, Deok Gyeong Kang, Na‐Young Ha, Jin Sook Ahn, Hey Y. Cho, Sung‐Jo Kang, Young‐Joon Lee, Soon‐Chan Hong
SJR Q2FWCI 7.2Electrophoresis

Hepatocellular carcinoma (HCC) is a common malignancy worldwide and is a leading cause of death. To contribute to the development and improvement of molecular markers for diagnostics and prognostics and of therapeutic targets for the disease, we have largely expanded the currently available human liver tissue maps and studied the differential expression of proteins in normal and cancer tissues. Reference two-dimensional electrophoresis (2-DE) maps of human liver tumor tissue include labeled 2-DE

SpectroscopyChemistry
5
논문|인용수 111·2004
Polymorphism in folate- and methionine-metabolizing enzyme and aberrant CpG island hypermethylation in uterine cervical cancer
Sokbom Kang, Jae‐Weon Kim, Gyeong Hoon Kang, Noh Hyun Park, Yong Sang Song, Soon Beom Kang, Hyo Pyo Lee
SJR Q1FWCI 2.6Gynecologic Oncology
Molecular BiologyBiochemistry, Genetics and Molecular Biology
6
논문|인용수 106·2014
Connectomic Disturbances in Attention-Deficit/Hyperactivity Disorder: A Whole-Brain Tractography Analysis
Soon-Beom Hong, Andrew Zalesky, Alex Fornito, Subin Park, Young-Hui Yang, Min-Hyeon Park, In Chan Song, Chul‐Ho Sohn, Min‐Sup Shin, Bung-Nyun Kim, Soo‐Churl Cho, Doug Hyun Han
SJR Q1FWCI 9.1Biological PsychiatryOA
Psychiatry and Mental healthMedicine
7
논문|인용수 99·2006
Feasibility of ovarian preservation in patients with early stage endometrial carcinoma
Taek Sang Lee, Ji Ye Jung, Jae‐Weon Kim, Noh-Hyun Park, Yong Sang Song, Soon‐Beom Kang, Hyo‐Pyo Lee
SJR Q1FWCI 5.6Gynecologic Oncology
Reproductive MedicineMedicine
8
논문|인용수 98·2009
Genetic polymorphisms affecting clinical outcomes in epithelial ovarian cancer patients treated with taxanes and platinum compounds: A Korean population-based study
Hee Seung Kim, Mi‐Kyung Kim, Hyun Hoon Chung, Jae‐Weon Kim, Noh Hyun Park, Yong Sang Song, Soon Beom Kang
SJR Q1FWCI 9.7Gynecologic Oncology
Reproductive MedicineMedicine
9
논문|인용수 94·2010
Neutrophil to lymphocyte ratio for preoperative diagnosis of uterine sarcomas: A case-matched comparison
Heung‐Sik Kim, Kyuhee Han, Hyun Hoon Chung, Jae‐Weon Kim, N.H. Park, Yong Sang Song, Sokbom Kang
SJR Q1FWCI 4.3European Journal of Surgical Oncology
Obstetrics and GynecologyMedicine
10
논문|인용수 93·2005
Comparison of DNA hypermethylation patterns in different types of uterine cancer: Cervical squamous cell carcinoma, cervical adenocarcinoma and endometrial adenocarcinoma
Sokbom Kang, Jae‐Weon Kim, Gyeong Hoon Kang, Sun Lee, Noh Hyun Park, Yong Sang Song, Sang‐Yoon Park, Soon Beom Kang, Hyo Pyo Lee
SJR Q1FWCI 2.6International Journal of CancerOA

The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of cervical carcinoma, we investigated the DNA promoter hypermethylation profiles in CA and CSCC. In addition, we investigated whether DNA hypermethylation patterns might be used for t

Molecular BiologyBiochemistry, Genetics and Molecular Biology
11
논문|인용수 89·2015
Predicting Methylphenidate Response in ADHD Using Machine Learning Approaches
Jae-Won Kim, Vinod Sharma, Neal D. Ryan
SJR Q1FWCI 4.6The International Journal of NeuropsychopharmacologyOA

Our results provide preliminary support to the translational development of support vector machine as an informative method that can assist in predicting treatment response in attention deficit hyperactivity disorder, though further work is required to provide enhanced levels of classification performance.

Psychiatry and Mental healthMedicine
12
논문|인용수 84·2002
Interleukin-10 promoter polymorphisms and cervical cancer risk in Korean women
Ju‐Won Roh, Moon Hong Kim, Sang Soo Seo, Su Hyeong Kim, Jae‐Weon Kim, Noh Hyun Park, Yong Sang Song, Sang‐Yoon Park, Soon Beom Kang, Hyo Pyo Lee
SJR Q1FWCI 1.8Cancer Letters
ImmunologyImmunology and Microbiology
13
논문|인용수 82·2012
Ginsenoside Rg3 attenuates tumor angiogenesis via inhibiting bioactivities of endothelial progenitor cells
Jaewon Kim, Seok-Yun Jung, Yi-Hong Kwon, Jun‐Hee Lee, You Mie Lee, Boo-Yong Lee, Sang‐Mo Kwon
SJR Q1FWCI 2.8Cancer Biology & TherapyOA

Accumulating evidence suggests that Ginsenoside Rg3 appears to inhibit tumor growth including Lewis lung carcinoma, intestinal adenocarcinomas or B16 melanoma by inhibiting cell proliferation, tumor cell invasion and metastasis. Endothelial progenitor cells (EPCs) appear to play a key role in the growth of early tumors by intervening with the angiogenic switch promoting tumor neovessel formation by producing angiogenic cytokines during tumor progression. This paper reports a novel mechanism of G

Molecular BiologyBiochemistry, Genetics and Molecular Biology
14
논문|인용수 80·2013
Outcomes of ovarian preservation in a cohort of premenopausal women with early-stage endometrial cancer: A Korean Gynecologic Oncology Group study
Taek Sang Lee, Jung‐Yun Lee, Jae‐Weon Kim, Sohee Oh, Seok Ju Seong, Jong‐Min Lee, Tae Jin Kim, Chi‐Heum Cho, Seok‐Mo Kim, Chan-Yong Park
SJR Q1FWCI 5.1Gynecologic Oncology
Obstetrics and GynecologyMedicine
15
리뷰|인용수 79·2014
Inflammatory Markers and the Pathogenesis of Pediatric Depression and Suicide
Jae-Won Kim, Eva Szigethy, Nadine Melhem, Ester Saghafi, David A. Brent
SJR Q1FWCI 1.6The Journal of Clinical Psychiatry

The extant literature provides sufficient data to support a link between inflammatory processes and pediatric depression. However, the directionality of the associations and pathways between the 2 conditions remains to be elucidated. At present, there is insufficient evidence to support the relationship between inflammation and suicidality in youth. Studies on inflammatory medical conditions are warranted in order to understand biological pathways linking inflammation and depression.

Biological PsychiatryNeuroscience

대표 연구 분야

Obstetrics and GynecologyReproductive MedicinePsychiatry and Mental healthMolecular BiologyElectrical and Electronic EngineeringEpidemiology

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