김재원 교수
Jae-Weon Kim
서울대학교 · 의학
연구실 소개
김재원 교수의 연구실은 주로 종양 생물학과 분자 의학 분야에서 활동하며, 암의 발병 기전과 치료 타겟을 규명하는 데 초점을 맞추고 있습니다. 특히 간세포암, 자궁경부암, 폐암 등 다양한 암 종양에서의 유전자 발현 변화, 염증 반응과 정서 장애의 연관성, 그리고 천연물질(예: 진세노사이드 Rg3)이 혈관신생을 억제하는 메커니즘을 연구하고 있습니다. 또한, 단백질 지ap 및 메틸화 프로파일을 기반으로 한 진단 및 예후 생물학적 마커 개발에도 기여하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15This article explores the effects of team voice and worker representative voice, as well as their interaction, on labor productivity. We examine team voice in terms of team influence on key work-related issues and representative voice via the degree of worker representatives’ influence on multiple collective voice issues. We thus build on the European tradition of examining both direct and indirect voice and their implications for valued organizational outcomes. We find that neither type of voic
Hepatocellular carcinoma (HCC) is a common malignancy worldwide and is a leading cause of death. To contribute to the development and improvement of molecular markers for diagnostics and prognostics and of therapeutic targets for the disease, we have largely expanded the currently available human liver tissue maps and studied the differential expression of proteins in normal and cancer tissues. Reference two-dimensional electrophoresis (2-DE) maps of human liver tumor tissue include labeled 2-DE
The incidence of cervical adenocarcinoma (CA) is rising, whereas the incidence of cervical squamous cell carcinoma (CSCC) continues to decrease. However, it is still unclear whether different molecular characteristics underlie these 2 types of cervical carcinoma. To better understand the epigenetic characteristics of cervical carcinoma, we investigated the DNA promoter hypermethylation profiles in CA and CSCC. In addition, we investigated whether DNA hypermethylation patterns might be used for t
Our results provide preliminary support to the translational development of support vector machine as an informative method that can assist in predicting treatment response in attention deficit hyperactivity disorder, though further work is required to provide enhanced levels of classification performance.
Accumulating evidence suggests that Ginsenoside Rg3 appears to inhibit tumor growth including Lewis lung carcinoma, intestinal adenocarcinomas or B16 melanoma by inhibiting cell proliferation, tumor cell invasion and metastasis. Endothelial progenitor cells (EPCs) appear to play a key role in the growth of early tumors by intervening with the angiogenic switch promoting tumor neovessel formation by producing angiogenic cytokines during tumor progression. This paper reports a novel mechanism of G
The extant literature provides sufficient data to support a link between inflammatory processes and pediatric depression. However, the directionality of the associations and pathways between the 2 conditions remains to be elucidated. At present, there is insufficient evidence to support the relationship between inflammation and suicidality in youth. Studies on inflammatory medical conditions are warranted in order to understand biological pathways linking inflammation and depression.
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