김지훈 교수

The adrenal gland plays a pivotal role in an organism's health span by controlling the endocrine system. Decades of research on the adrenal gland have provided multiscale insights into the development and maintenance of this essential organ. A particularly interesting finding is that founder stem/progenitor cells participate in adrenocortical development and enable the adult adrenal cortex to regenerate itself in response to hormonal stress and injury. Since major advances have been made in unde

The survival of motor neuron (SMN) protein is a major component of the pre-mRNA splicing machinery and is required for RNA metabolism. Although SMN has been considered a fundamental gene for the central nervous system, due to its relationship with neuromuscular diseases, such as spinal muscular atrophy, recent studies have also revealed the requirement of SMN in non-neuronal cells in the peripheral regions. Here, we report that the fibro-adipogenic progenitor subpopulation expressing Dpp4 (Dpp4+

This study presents a new mobile robot with passively articulated driving tracks for high terrainability (TA) and maneuverability (MA) on unstructured, rough terrain. The mobile robot consists of four driving tracks, two rocker links, and four pitch-roll two-degrees-offreedom (2-DOF) passive joints. For performance evaluation, the proposed mechanism was compared with several existing mechanisms, including four tracked mechanisms and three wheel linkage-type mechanisms. Dynamic simulations of ref

Erythorbyl fatty acid esters (EFEs) are promising multifunctional food emulsifiers with antibacterial and antioxidative activities. Variations in the alkyl chain of EFEs may alter the physicochemical properties, affecting their multifunctional characteristics. Herein, the effect of alkyl chain length of EFEs on the multifunctionality was investigated by comparing the interfacial, antibacterial, and antioxidative activities of homologous series of EFEs with different saturated fatty acids (C10:0-

The electrical conduction properties of 10-nm-thick atomic-layer deposited Al2O3 thin films with Al bottom and Pt top electrodes were characterized for use in field emission display. The as-deposited films, grown at 300 °C, exhibited such a high electrical leakage that their electrical properties could not be measured. However, post-treatment at 300 °C under a remote O2 or H2O plasma for 30 min improved the insulating properties of the Al2O3 films. However, the electrical conduction mechanism, p

During exercise, skeletal muscle is exposed to a low oxygen condition, hypoxia. Under hypoxia, the transcription factor hypoxia-inducible factor-1α (HIF-1α) is stabilized and induces expressions of its target genes regulating glycolytic metabolism. Here, using a skeletal muscle-specific gene ablation mouse model, we show that Brg1/Brm-associated factor 155 (Baf155), a core subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, is essential for HIF-1α signaling in skeletal muscle. Muscl

Background: Whether depression before diagnosis of dyslipidemia is associated with higher cardiovascular disease (CVD) risk among newly diagnosed dyslipidemia patients is yet unclear. Methods: The study population consisted of 72,235 newly diagnosed dyslipidemia patients during 2003 to 2012 from the National Health Insurance Service–Health Screening Cohort of South Korea. Newly diagnosed dyslipidemia patients were then detected for pre-existing depression within 3 years before dyslipidemia diagn

Objective: To evaluate the temporal evolution and diagnostic values of the diffusion tensor imaging (DTI) and the high b value diffusion weighted imaging (DWI) in the early permanent and transient cerebral ischemia. Materials and Methods: For permanent or 30-minute transient-ischemia induced 30 rats, DTI and DWIs at both high b (b = 3000 s/mm2) and standard b value (b = 1000 s/mm2) were obtained at the following conditions: at 15, 30, 45, 60 minutes after the occlusion of what for hyperacute per

Objectives The purpose of this study was to determine the effect of resin infiltration technique on color and surface hardness of white spot lesion (WSL) with various degrees of demineralization. Materials and Methods Ten human upper premolars were cut and divided into quarters with a 3 × 4 mm window on the enamel surface. Each specimens were separated into four groups (n = 10) and immersed in demineralization solution to create WSL: control, no treatment (baseline); 12 h, 12 hr demineralization

A 94 GHz CMOS resistive mixer is presented using the 65 nm CMOS process. Parasitic losses which are serious at high frequencies are minimised by adopting the optimised transistor size and symmetric transistor layouts as well as a scaled‐down 65 nm CMOS technology, which contribute to reducing the conversion loss at 94 GHz by 2–3 dB, the conversion loss being 8.8–9.2 dB from 87 to 94 GHz of RF frequencies with an LO power of <7.6 dBm. To the best of the authors' knowledge, this is the best per

Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle and other metabolic organs in terms of systemic energy homeostasis. This conceptual basis of skeletal muscle as a metabolically active organ has provided insights into the potential role of physical inactivity and conditions altering muscle quality and quantity in the development of multiple metabolic d