정진욱 교수
Jin Wook Jeoung
서울대학교 · 의학
연구실 소개
정진욱 교수 연구실은 망막 신경망막층과 시신경축의 구조적 변화를 고해상도 산란광학단층촬영(ОСТ)을 활용해 분석하며, 특히 매크로 영역의 GCIPL 두께와 RNFL 두께의 진단 능력을 체계적으로 평가하고 있습니다. 고도근시 환자에서의 매크로 GCIPL 측정이 전통적인 peripapillary RNFL 측정과 유사한 진단 정확도를 보임을 규명하였고, 딥러닝 기반 분석 시스템을 통해 조기 간질성 변화를 보다 정밀하게 탐지하는 데에도 기여하고 있습니다. 또한 수술 후 생체측정 오차와 시신경축 변화의 영향을 분석함으로써, 진단 정확도 향상을 위한 기반 데이터를 제공하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15There were no significant differences between the AUROCs for Cirrus GCIPL, RNFL, and ONH parameters, indicating that these maps have similar diagnostic potentials for glaucoma. The minimum GCIPL showed better glaucoma diagnostic performance than the other parameters at comparable specificities. However, other GCIPL parameters showed performances comparable to those of the RNFL parameters.
In cases of high myopia, the glaucoma detection ability of macular GCIPL thickness was high and comparable with that of peripapillary RNFL thickness.
There were no significant differences between the AUROCs for Cirrus and Stratus OCT, indicating that the two devices have similar diagnostic potentials in preperimetric glaucoma. After comparison with their normative databases, Cirrus OCT had generally higher sensitivities; however, this was largely at the cost of lower specificities than Stratus OCT.
The combined surgery included a small biometric error that was within the tolerable range in most cases. However, myopic shifts developed in patients with long axial lengths, poor preoperative visual acuity, and the preoperative presence of foveal detachment.
The diagnostic ability of segmented mRNFL and GCL to discriminate between normal and glaucoma eyes is high and comparable to that of cpRNFL thickness. The measurement and monitoring of GCL could be a practical and effective approach to glaucoma diagnostics.
An SD-OCT-based deep learning system can detect glaucomatous structural change with high sensitivity and specificity.
LC posterior bowing was increased in POAG eyes, and was significantly associated with structural optic nerve head (ONH) changes but not with functional glaucoma severity. Quantitative evaluation of LC curvature can facilitate assessment of glaucomatous ONH change.
The wide-field RNFL thickness map using SS-OCT performed well in distinguishing eyes with PPG and EG from healthy eyes. In the clinical setting, wide-field RNFL maps of SS-OCT can be useful tools for detection of early-stage glaucoma.
The diagnostic ability of macular GCIPL parameters was comparable to that of peripapillary RNFL and ONH parameters in PPG. The inner directional angle of RNFL defects, but not the angular width, affects the diagnostic sensitivity of macular GCIPL parameters.
Objective: We wanted to investigate the prevalence and causative factors of extrahepatic arterial blood supply to hepatocellular carcinoma (HCC) at its initial presentation and during chemoembolization. Materials and Methods: Between February 1998 and April 2000, consecutive 479 patients with newly diagnosed HCC were prospectively enrolled into this study. A total of 1629 sessions of transcatheter arterial chemoembolization (TACE) were performed in these patients (range: 1 15 sessions; mean: 3.4
In the health-center-based Korean population, the 5-year incidence of POAG was 0.72%, and the rate of progression from POAG suspect to definite POAG was 4.75% per year. This study identified old age, high baseline IOP, high BMI, high level of education, and high hematocrit level as significant risk factors for incident POAG.
There was no single case of pRNFL defect in the MVZ without inferior mGCIPL loss. However, there were a few cases of inferior mGCIPL loss without pRNFL defect in the MVZ. These findings signify that detection of inferior mGCIPL loss might be earlier than that of pRNFL defect in the MVZ. Therefore, pRNFL analysis of the optical coherence tomography disc cube scan alone is insufficient for detection of early-stage glaucomatous damage.
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