이주희 교수
Joo Hee Lee
서울대학교 · 공학
연구실 소개
이주희 교수의 연구실은 신경퇴행성질환, 특히 알츠하이머병의 병태생리 기전을 해소하기 위한 자연물 기반 약물 개발과 신경세포 재생 가능성 탐색에 초점을 맞추고 있습니다. 또한, 갈락토스를 타가투오스로 전환하는 효소 및 비효소적 경로의 최적화를 통해 저칼로리 천연당 생산 기술을 개발하고 있으며, FDG PET/CT 영상 분석을 통한 자가면역질환인 IgG4 관련 질환의 조기 진단 기법도 연구하고 있습니다. 특히, 치아에서 유래한 줄기세포의 신경세포 분화 능력에 대한 기초 연구를 통해 신경질환 치료에 활용 가능한 새로운 세포 기반 전략을 모색하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15FDG PET/CT findings may have the capacity to potentially differentiate IgG4 RD from other diseases in clinically suspected patients.
A numerical analysis is performed to investigate the aerodynamic characteristics and the static height stability of the endplate and the anhedral angle on an aspect-ratio-one wing-in-ground effect. The analysis shows that the ground effect increases the lift by the high pressure on the lower surface, reduces the drag, increases the suction on the upper surface, and considerably enhances the lift-drag ratio. The endplate, which prevents the high-pressure air from escaping out of the lower surface
Alzheimer's disease (AD) is a neurodegenerative disease characterized by severe brain damage and dementia. There are currently few therapeutics to treat this disease, and they can only temporarily alleviate some of the symptoms. The pathogenesis of AD is mainly preceded by accumulation of abnormal amyloid beta (Aβ) aggregates, which are toxic to neurons. Therefore, modulation of the formation of these abnormal aggregates is strongly suggested as the most effective approach to treat AD. In partic
Human dental stem cells including DPSCs, PDLSCs, and SCAP may have neurogenic differentiation capability in vitro. The presented data support the use of human dental stem cells as a possible alternative source of stem cells for therapeutic utility in the treatment of neurological diseases.
The valorization of galactose derived from acid whey to low-calorie tagatose has gained increasing attention. Enzymatic isomerization is of great interest but faces several challenges, such as poor thermal stability of enzymes and a long processing time. In this work, non-enzymatic (supercritical fluids, triethylamine, arginine, boronate affinity, hydrotalcite, Sn-β zeolite, and calcium hydroxide) pathways for galactose to tagatose isomerization were critically discussed. Unfortunately, most of
SUV<sub>avg</sub> and Masaoka stage are independent prognostic factors in thymic epithelial tumors.
We aimed to evaluate the accuracy of coronary computed tomography angiography (CCTA) with a low-radiation protocol and iterative model reconstruction (IMR), in comparison with invasive coronary angiography (ICA). Sixty-one patients (45 males; mean age, 61.9 ± 9.2 years) with suspected coronary artery disease who underwent CCTA and ICA were retrospectively enrolled. CCTA was performed with low tube voltage (80 or 100 kVp), low tube current (100-200 mAs), prospective ECG triggering, and IMR using
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