신정훈 교수

Tumor PD-L1 expression increased after platinum-based NACT in a significant proportion of patients with NSCLC. Increase in tumor PD-L1 expression may predict poor clinical outcome.

"Globalization, the City and Civil Society in Pacific Asia: The Social Production of Civic Spaces." Journal of Architectural Education, 63(2), pp. 175–176

This study addresses an integrated batching and scheduling problem for a single-machine flexible machining cell in which each pallet can load multiple parts, i.e. multi-fixturing pallets, and part processing times can be changed with different processing costs, i.e. controllable processing times. The batching sub-problem is to select the set of parts to be produced in each period of a planning horizon and the resulting scheduling sub-problem is to determine the set of parts to be loaded on each

In our study, MM patients aged 40 years or younger at diagnosis showed no superior survival compared to those of the moderately elderly patients based on historical data.

Although nilotinib has improved efficacy compared to imatinib, suboptimal response and intolerable adverse events (AEs) limit its effectiveness in many patients with chronic myeloid leukemia in chronic phase (CML-CP). We investigated the 2-year efficacy and safety of nilotinib and their relationships with plasma nilotinib concentrations (PNCs). In this open-label, multi-institutional phase 4 study, 110 Philadelphia chromosome-positive CML-CP patients were treated with nilotinib at a starting dos

This paper deals with parameter tuning of the Power System Stabilizer (PSS) for 612 MVA thermal power plants in the KEPCO system and its validation in a field test. In this paper, the selection of parameters, such as lead-lag time constants for phase compensation and system gain, is optimized using linear and eigenvalue analyses. This is then verified through the time-domain transient stability analysis. In the next step, the performance of PSS is finally verified by the generator's on-line fiel

Primary effusion lymphoma (PEL) is a rare type of non-Hodgkin's lymphoma arising from a B-cell lineage characterized by the formation of malignant effusion in body cavities without evidence of a detectable tumor. The effusion contains tumor cells universally infected with human herpesvirus 8 (HHV8), which is the critical factor differentiating PEL from HHV8-unrelated PEL-like lymphoma (PEL-LL). This report describes a 77-year-old male patient with pleural effusion and ascites, containing lymphom

PEL mostly occurred in ostensibly immunocompetent individuals and had a favorable outcome in Korea. A watchful waiting approach may be applicable for managing HIV-seronegative patients with PEL with a low Ki-67 labeling index. A possible trend was detected among LANA1, CD20, and CD30 expression in BCBL.

DNA helicases play essential roles in many cellular processes. The currently available techniques to generate substrates for helicase assays are fairly complicated and need some expertise not available in all laboratories. Here, a PCR-based method to generate a substrate for a helicase assay is described, and its application for several archaeal, bacterial and viral enzymes is demonstrated.

Embitterment was prevalent among the unemployed participants and embitterment was a reactive emotion following personal downgrading, not so much related to conditions in the world at large. Thus, we recommend developing a screening program to detect extreme embitterment and an interventional program to help people better cope with emotional stress due to job loss. Efforts should be made to restore their violated expectation and trust that they would be treated in a just and fair way.

본 논문에서는 전력계통에서 발생하는 저주파 진동을 억제하여 계통에 댐핑력을 제공함으로써 계통 안정도를 향상시킬 수 있는 전력계통 안정화장치의 정수선정 기법과 현장시험을 통한 성능검증 방법을 제시하였다. 대상 발전기는 우리나라 계통에 설치되어 있는 612[MVA]급 화력발전기이며, 축 속도를 입력으로 하는 아날로그 전력계통 안정화장치를 적용대상으로 하였다. 본 논문에서는 먼저, 오프라인에서 선형 해석 및 고유치 해석을 통하여 최적정수를 선정하는 기법을 제시하고, 시간영역 과도 안정도 해석을 이용하여 선정된 정수를 검증하였다(Part I). 또한, 선정된 전력계통 안정화장치의 성능을 온라인 현장시험을 통하여 최종적으로 검증하였으며, 정수선정 전 후의 오프라인 시뮬레이션 결과와 온라인 시험결과를 비교?분석함으로써, 결정된 모델의 적정성을 확인하였다(Part II). 이를 통하여, 축 속도를 입력으로 하는 PSS의 정수선정 방법과 실 계통 현장시험을 통한 성능검증 방법을 제시하였다.