이정 교수
Jung Lee
서울대학교 · 심리학
연구실 소개
이 교수의 연구실은 주로 약물 합성과 생물학적 활성 물질의 개발에 초점을 맞추고 있으며, 고유한 구조를 가진 퀴옥사린온 및 벤조다이아제핀계 화합물의 고체상 합성 기법을 응용하여 약물 후보 물질을 효율적으로 제조합니다. 또한, 암세포에 대한 천연물 성분의 세포 선택성과 세포 내 축적 메커니즘을 규명하는 데에도 주력하고 있으며, 특히 한국인삼의 주요 성분인 진세노사이드의 생물학적 기전을 분석합니다. 특히 소아 중증 중추신경계 손상과 심정지의 응급 처치 및 예후에 관한 임상 연구를 통해 의료 현장의 실질적 개선 방안을 모색하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15A central and persisting issue in educational technology is the provision of instructional environments and conditions that can comply with individually different educational goals and learning abilities. Instructional approaches and techniques that are geared to meet the needs of the individually different student are called adaptive instruction (Como & Snow, 1986). More specifically, adaptive instruction refers to educational interventions aimed at effectively accommodating individual differen
Near-infrared light (NIL) promotes a wide range of biological effects including enhancement of energy production, gene expression and prevention of cell death. This is the first report of the in vivo neuroprotective effects of NIL against optic neuropathy induced by mitochondrial complex I inhibition. Subjects were pigmented rats that received single bilateral intravitreal doses of rotenone, a mitochondrial complex I inhibitor, or rotenone plus one of three different doses of NIL. Treatment effe
Delirium-identification algorithms in claims data have low sensitivity and high specificity. Defining delirium using ICD diagnosis codes or antipsychotics use performs better than considering either type of information alone. This information should inform the design and interpretation of claims-based comparative effectiveness and safety research. Copyright © 2017 John Wiley & Sons, Ltd.
This study evaluated the effects of exergaming on college students' energy expenditure (EE), moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), rating of perceived exertion (RPE), and enjoyment compared to traditional treadmill exercise, and sex differences. Sixty college students (30 female; X ¯ <sub>age</sub> = 23.6 ± 4.1 years) completed three 20-min exercise sessions on Xbox 360 Kinect Just Dance (Microsoft, Redmond, WA, USA), Xbox 360 Kinect Reflex Ridge (Microsof
Objective: To prospectively evaluate the safety and short-term therapeutic efficacy of switching monopolar radiofrequency ablation (RFA) with multiple electrodes to treat medium-sized (3.1-5.0 cm), hepatocellular carcinomas (HCC). Materials and Methods: In this prospective study, 30 patients with single medium-sized HCCs (mean, 3.5 cm; range, 3.1-4.4 cm) were enrolled. The patients were treated under ultrasonographic guidance by percutaneous switching monopolar RFA with a multichannel RF generat
The preliminary results of this cohort study suggest that the DLPFC volumetric and rsFC changes may serve as potential neurobiological treatment markers that are associated with symptom improvement in adolescents with MDD.
Literature suggests that neurobiological factors such as brain structure play an important role in linking social stress with depression in adolescence. We aimed to examine the role of subcortical volumetric alteration in the association between peer problems as one type of social stress and adolescent depression. We hypothesized that there would be indirect effects of peer problems on adolescent depression through subcortical volumetric alteration. Seventy eight adolescents with major depressiv
Our smartphone app demonstrated preliminary evidence of predicting diagnosis and treatment response in depressed adolescents. This is the first study to predict the treatment response of adolescents with MDD by examining smartphone-based objective data with deep learning approaches.
The pediatricians differed in their experiences and attitudes toward advance care planning based on their subspecialty. Consequently, institutional support and education should be provided to physicians so that they can include children and families in discussions on prognosis.
The observed topological reorganization, underconnectivity, and disrupted efficiency in the default mode network subregions and social function-related regions could be significant biomarkers of childhood ASD.
The Korean SCARED demonstrated promising psychometric properties, and could be a valid scale for screening anxiety symptoms in primary care. The fact that different items comprised the factors may reflect the cultural difference between United States and Korea in experiencing anxiety.
이 논문은 아토피 질환에 대한 ‘한국적’인 이해와 대응을 낳은 역사적 과정을 살펴본다. 유전적 소인이 있는 특이면역성 질환 아토피는 외국의 경우에 ‘환경병’으로 인식되는 경우가 드물다. 하지만 한국에서 아토피는 ‘환경호르몬’ 등의 위험요소들과 결부되며 대표적 환경병의 지위를 갖고 있다. 아토피에 대한 이러한 이해는 사전예방원칙과, 매체중심이 아닌 수용자중심의 환경오염 관리라는 전향적 원칙을 내세운 2008년의 환경보건법 탄생에 중요한 역할을 했다. 이 논문은 이 규제과정에 있어서 대중의 지식적․정치적 활동의 역할을 살펴본다. ‘아토피 = 환경병’으로 아토피를 이해하는 데 있어 가장 중요한 역할을 한 것은 아토피 아이들을 둔 아토피 엄마들이다. 이들은 의학과 독성학 등 과학계의 성과는 물론 일본의 ‘아토피 아이, 지구의 아이’와 같은 환자조직의 활동경험과 성과를 이용, 대중적 호소력을 발휘한 ‘아토피 이론’을 제시했다. 이들은 과학적 불확실성을 전용하는 한편, 한의학계, 생협, 민노당
대표 연구 분야
이정 교수의 연구를 Nubint에서 더 깊이 살펴보세요
이 연구실의 논문을 앱에서 열어 AI와 함께 읽고, 핵심을 요약하고, 내 글에 인용하세요.