서강문 교수
Kangmoon Seo
서울대학교 · 의학
연구실 소개
서강문 교수의 연구실은 동물의 안과 질환, 특히 개와 비둘기 등의 눈에서 발생하는 내과적 및 수술적 치료법을 중심으로 연구를 진행하고 있습니다. 특히 녹내환자 치료를 위한 프로스타글란딘 유사제의 효과, 안압 측정 기기의 정확성 평가, 백내장 수술 시의 마취 및 수술 환경 개선 방법 등 임상적 응용가치가 높은 연구를 지속적으로 수행하고 있습니다. 또한 눈물막 기능 이상과 망막질환의 기전 규명에도 관심을 기울이며, 동물 모델을 통한 진단 및 치료 기법 개발에 기여하고 있습니다.
연구 현황
연구 성과 추이
표시된 성과는 수집된 데이터 기준으로 산출되며, 일부 차이가 있을 수 있습니다.
주요 논문
15Instillation of PF tafluprost lowered IOP and induced miosis in normal canine eyes. Alterations in ICA and CCW occurred simultaneously, which probably affected the outflow of aqueous humor. PF tafluprost could be considered an alternative prostaglandin analog in the treatment of canine glaucoma.
Sub-Tenon injection of lidocaine was an effective method for inducing akinesia of extraocular muscles, mydriasis, and intraoperative analgesia for phacoemulsification in dogs. Therefore, this could be another option for surgical field exposure and pain management during phacoemulsification in dogs.
We evaluated the applicability of a rebound tonometer (TonoVet) in pigeon eyes and established normal reference intraocular pressure (IOP) values in healthy pigeons; 20 eyes of euthanized pigeons were used for calibration of the TonoVet and 48 eyes of 24 adult pigeons were used for measurement of reference IOP. First, IOP of pigeon eyes ex vivo were measured using the 'd' and the 'p' modes of the TonoVet and compared to manometric IOP values from 5 to 80 mm Hg. Then, to establish normal referenc
The topical latanoprost widened the ciliary cleft despite the narrowing of the ICA and CC entry. Time-dependent alterations in the CBT were demonstrated by the UBM and might be a reflection of the mechanism of the uveoscleral outflow enhancement induced by the topical latanoprost.
This study demonstrates that the TONOVET<sup>®</sup> and TONOVET-Plus<sup>®</sup> provide a useful approach for ex vivo analysis. In clinical trials, results of TV-IOP and SW-IOP were significantly lower than of TVP-IOP when IOP was higher than 14 mm Hg of TVP-IOP. The characteristics of rebound tonometers should be considered in clinical settings.
Low interferometry and NIBUT grades were associated with MGD, suggesting decreased meibum and disrupted tear film quality. TMH did not differ between the two groups. Meibography could aid in the diagnosis of MGD in severe cases, although it could not detect early MGD in the dogs in this study.
The results indicated that increased VDU was associated with more severe cataract grades in dogs.
Low fluidic parameters led to decreased fluid passage through the zonules, reducing fluid passage into the vitreous. These may also lead to reduced surgical stress on the intraocular tissues by decreasing the amount of irrigation solution used during phacoemulsification in the dog.
Sub-Tenon's lidocaine injections provide excellent akinesia and mydriasis compared to systemic AT and retrobulbar lidocaine injections. Therefore, sub-Tenon's anesthesia could be an alternative to the systemic administration of neuromuscular blockers and retrobulbar anesthesia for ophthalmic surgery in dogs.
This study evaluated the surgical outcome and complications of phacoemulsification and the implantation of an acryl foldable intraocular lens (IOL) with a squared edge in dogs with cataracts. Thirty-two eyes from 26 dogs were examined. The mean follow up period was 75.9 days ranging from 23 to 226 days. The complications after phacoemulsification were posterior capsular opacity (PCO) around the IOL (n = 11), ocular hypertension (n = 4), focal posterior synechia (n = 4), hyphema (n = 3) and corne
This study was conducted to compare the effects of 3 different sedative agents on electroretinography (ERG) in domestic pigeons (<i>Columba livia</i>). Six pigeons were sedated with alfaxalone, xylazine, and medetomidine at separate times with a 1-week washout period between sedative administration. After sedation with each agent, pigeons underwent the modified ERG protocol adapted from the standardized protocol for dogs. The scotopic mixed rod and cone response was recorded after 20 minutes of
Ultrasound biomicroscopy could be a useful diagnostic tool to evaluate anterior ocular segment of pigeons.
A mongrel male dog of three years old was referred to the Seoul National University Veterinary Teaching Hospital following a one month history of glaucoma. On ophthalmic examination, hyphema, glaucoma, uveitis, iridal mass, and loss of vision were noted in the right eye. Ultrasonography and computed tomography revealed a mass with involvement of the entire uvea. Radiographic evaluation did not reveal any evidence of distant metastasis. The right eye was surgically removed because of the high lik
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